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- W4212829327 endingPage "2053" @default.
- W4212829327 startingPage "2053" @default.
- W4212829327 abstract "SALL4, a member of the SALL family, is an embryonic stem cell regulator involved in self-renewal and pluripotency. Recently, SALL4 overexpression was found in malignant cancers, including lung cancer, hepatocellular carcinoma, breast cancer, gastric cancer, colorectal cancer, osteosarcoma, acute myeloid leukemia, ovarian cancer, and glioma. This review updates recent advances of our knowledge of the biology of SALL4 with a focus on its mechanisms and regulatory functions in tumors and human hematopoiesis. SALL4 overexpression promotes proliferation, development, invasion, and migration in cancers through activation of the Wnt/β-catenin, PI3K/AKT, and Notch signaling pathways; expression of mitochondrial oxidative phosphorylation genes; and inhibition of the expression of the Bcl-2 family, caspase-related proteins, and death receptors. Additionally, SALL4 regulates tumor progression correlated with the immune microenvironment involved in the TNF family and gene expression through epigenetic mechanisms, consequently affecting hematopoiesis. Therefore, SALL4 plays a critical oncogenic role in gene transcription and tumor growth. However, there are still some scientific hypotheses to be tested regarding whether SALL4 is a therapeutic target, such as different tumor microenvironments and drug resistance. Thus, an in-depth understanding and study of the functions and mechanisms of SALL4 in cancer may help develop novel strategies for cancer therapy." @default.
- W4212829327 created "2022-02-24" @default.
- W4212829327 creator A5000944288 @default.
- W4212829327 creator A5001235833 @default.
- W4212829327 creator A5020545963 @default.
- W4212829327 creator A5067295868 @default.
- W4212829327 date "2022-02-12" @default.
- W4212829327 modified "2023-10-18" @default.
- W4212829327 title "SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance" @default.
- W4212829327 cites W1483496013 @default.
- W4212829327 cites W1594781119 @default.
- W4212829327 cites W1757407923 @default.
- W4212829327 cites W1812191961 @default.
- W4212829327 cites W1954845453 @default.
- W4212829327 cites W1968214308 @default.
- W4212829327 cites W1971368417 @default.
- W4212829327 cites W1974567048 @default.
- W4212829327 cites W1974634901 @default.
- W4212829327 cites W1975439559 @default.
- W4212829327 cites W1975773685 @default.
- W4212829327 cites W1977085420 @default.
- W4212829327 cites W1977447353 @default.
- W4212829327 cites W1978247080 @default.
- W4212829327 cites W1978468109 @default.
- W4212829327 cites W1979538859 @default.
- W4212829327 cites W1981066521 @default.
- W4212829327 cites W1982954748 @default.
- W4212829327 cites W1987855481 @default.
- W4212829327 cites W1988684923 @default.
- W4212829327 cites W1991408379 @default.
- W4212829327 cites W1992662525 @default.
- W4212829327 cites W1999178985 @default.
- W4212829327 cites W1999287489 @default.
- W4212829327 cites W2001257677 @default.
- W4212829327 cites W2001442967 @default.
- W4212829327 cites W2002513358 @default.
- W4212829327 cites W2005082854 @default.
- W4212829327 cites W2005190478 @default.
- W4212829327 cites W2005300267 @default.
- W4212829327 cites W2005601940 @default.
- W4212829327 cites W2006883359 @default.
- W4212829327 cites W2007563715 @default.
- W4212829327 cites W2015154759 @default.
- W4212829327 cites W2016206649 @default.
- W4212829327 cites W2020213730 @default.
- W4212829327 cites W2023181335 @default.
- W4212829327 cites W2023999038 @default.
- W4212829327 cites W2025673328 @default.
- W4212829327 cites W2033729556 @default.
- W4212829327 cites W2036411709 @default.
- W4212829327 cites W2039845199 @default.
- W4212829327 cites W2040935952 @default.
- W4212829327 cites W2041665938 @default.
- W4212829327 cites W2046201903 @default.
- W4212829327 cites W2050149565 @default.
- W4212829327 cites W2051298779 @default.
- W4212829327 cites W2051933106 @default.
- W4212829327 cites W2053840813 @default.
- W4212829327 cites W2054119257 @default.
- W4212829327 cites W2057452236 @default.
- W4212829327 cites W2059692892 @default.
- W4212829327 cites W2064160186 @default.
- W4212829327 cites W2075616704 @default.
- W4212829327 cites W2077135823 @default.
- W4212829327 cites W2087042197 @default.
- W4212829327 cites W2088883749 @default.
- W4212829327 cites W2091459202 @default.
- W4212829327 cites W2092193661 @default.
- W4212829327 cites W2093662470 @default.
- W4212829327 cites W2094498537 @default.
- W4212829327 cites W2095038551 @default.
- W4212829327 cites W2095782040 @default.
- W4212829327 cites W2096065464 @default.
- W4212829327 cites W2096753123 @default.
- W4212829327 cites W2100250094 @default.
- W4212829327 cites W2106787323 @default.
- W4212829327 cites W2107873095 @default.
- W4212829327 cites W2114409684 @default.
- W4212829327 cites W2114435237 @default.
- W4212829327 cites W2115840354 @default.
- W4212829327 cites W2122638939 @default.
- W4212829327 cites W2125629897 @default.
- W4212829327 cites W2127748864 @default.
- W4212829327 cites W2130072062 @default.
- W4212829327 cites W2132560319 @default.
- W4212829327 cites W2135132604 @default.
- W4212829327 cites W2136410889 @default.
- W4212829327 cites W2150839311 @default.
- W4212829327 cites W2155507705 @default.
- W4212829327 cites W2157023618 @default.
- W4212829327 cites W2158734599 @default.
- W4212829327 cites W2159702756 @default.
- W4212829327 cites W2161713093 @default.
- W4212829327 cites W2164817306 @default.
- W4212829327 cites W2167484872 @default.
- W4212829327 cites W2169988533 @default.
- W4212829327 cites W2170552969 @default.
- W4212829327 cites W2171143303 @default.