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- W4212852282 endingPage "89" @default.
- W4212852282 startingPage "73" @default.
- W4212852282 abstract "Genetic and epigenetic mechanisms are essential for gamete and embryo health and development. Most aneuploid human embryos result from errors during gamete meiosis checkpoints leading to lower chances of pregnancy or higher rates of miscarriage. Moreover, mitochondrial efficiency is needed for fertilization and early embryo development potential. Since mitochondria are often exposed to a powerful source of oxygen free radicals, mitochondrial DNA is highly vulnerable to mutations and pathologies. The global epigenetic reprogramming of oocyte and sperm is required to establish correct maternal and paternal genomic imprinting, a process in which only one member of an allele pair is expressed in a parent-of-origin manner. After fertilization, and before embryonic genome activation (EGA), maternal genes, mRNAs, and proteins stored in the oocyte are responsible for early embryo development. During EGA, maternal mRNAs and proteins are actively degraded, and both active and passive DNA demethylation is observed. After EGA, there is a de novo DNA methylation in the embryo, and an embryonic gene expression, with mRNA and proteins of embryonic origin. Recent studies have shown that microRNAs are largely expressed by blastocysts and endometrium, facilitating endometrial receptivity and embryo implantation. Lifestyle and environmental factors have a major influence on the gametogenesis, fertilization, and early embryo development, since they affect genomic and epigenomic events." @default.
- W4212852282 created "2022-02-24" @default.
- W4212852282 creator A5010745751 @default.
- W4212852282 creator A5062097899 @default.
- W4212852282 date "2022-01-01" @default.
- W4212852282 modified "2023-09-26" @default.
- W4212852282 title "Genetics and epigenetics of healthy gametes, conception, and pregnancy establishment: embryo, mtDNA, and disease" @default.
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