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- W4212856144 abstract "The closure of skin wounds is indispensable for resistance against pathogens, and fibroblast plays a critical role in skin wound healing. Our previous study demonstrates that the phosvitin-derived small peptide Pt5-1c not only possesses broad-spectrum antimicrobial activity but also exhibits synergistic effect and antibiofilm activity with traditional antibiotics against bacteria, including multi-drug resistant (MDR) strains. Here we provided the first evidence that Pt5-1c promoted the wound closure of surrogate scratch wounds of fibroblasts in vitro, and speeded up the healing and re-epithelialization of murine dermal wounds in vivo. We also showed that Pt5-1c activated migration of fibroblasts via a combined action of inducing migratory phenotype and trans-activating epidermal growth factor receptor (EGFR). Moreover, Pt5-1c accelerated attachment and proliferation of fibroblasts in vitro. Interestingly, Pt5-1c was able to promote collagen contraction through activation/differentiation of fibroblasts into myofibroblasts. These data together suggest that Pt5-1c is a promising candidate with therapeutic potential to promote wound healing." @default.
- W4212856144 created "2022-02-24" @default.
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- W4212856144 date "2022-04-01" @default.
- W4212856144 modified "2023-10-18" @default.
- W4212856144 title "In vitro and in vivo wound healing-promoting activities of phosvitin-derived peptide Pt5-1c" @default.
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- W4212856144 doi "https://doi.org/10.1016/j.ejphar.2022.174833" @default.
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