FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212857529> ?p ?o ?g. }

• W4212857529 endingPage "623" @default.
• W4212857529 startingPage "612" @default.
• W4212857529 abstract "The aim of this study was to investigate whether and how exosomal miR-205-5p regulated angiogenesis and nasopharyngeal carcinoma (NPC) metastasis. We found that up-regulated serum exosomal miR-205-5p levels were associated with NPC progression and worse overall survival of NPC patients. miR-205-5p over-expression significantly increased tube formation, wound healing, migration and invasion of NPC cells, and lung metastasis of NPC tumors, whereas miR-205-5p inhibition had opposite effects. Exosomal miR-205-5p from NPC cells promoted the migration, tube formation, and microvessel density (MVD) of HUVECs in vitro and in vivo. Furthermore, bioinformatics-, luciferase reporter-, and biotinylated miR-205-5p-based pull-down assays indicated that miR-205-5p directly bound to the 3' UTR of desmocollin-2 (DSC2). Exosomal miR-205-5p targeted DSC2 to enhance the EGFR/ERK signaling and MMP2/MMP9 expression, promoting angiogenesis and NPC metastasis, which was abrogated by DSC2 over-expression. Finally, the levels of miR-205-5p transcripts were positively correlated with MVD but negatively with DSC2 expression in NPC tissues, and patients with miR-205high/DSC2low NPC had worse overall survival. In conclusion, exosomal miR-205-5p promotes angiogenesis and NPC metastasis by targeting DSC2 to enhance EGFR/ERK signaling and MMP expression. This exosomal/miR-205-5p/EGFR/ERK axis may be a new therapeutic target for intervention of NPC metastasis." @default.
• W4212857529 created "2022-02-24" @default.
• W4212857529 creator A5007012774 @default.
• W4212857529 creator A5007926595 @default.
• W4212857529 creator A5024473487 @default.
• W4212857529 creator A5025735969 @default.
• W4212857529 creator A5034064562 @default.
• W4212857529 creator A5035321872 @default.
• W4212857529 creator A5037369783 @default.
• W4212857529 creator A5039311841 @default.
• W4212857529 creator A5040647242 @default.
• W4212857529 creator A5040924028 @default.
• W4212857529 creator A5041067091 @default.
• W4212857529 creator A5043058022 @default.
• W4212857529 creator A5043545709 @default.
• W4212857529 creator A5057504688 @default.
• W4212857529 creator A5062959247 @default.
• W4212857529 creator A5073464929 @default.
• W4212857529 creator A5075608733 @default.
• W4212857529 creator A5075753806 @default.
• W4212857529 creator A5076167118 @default.
• W4212857529 creator A5078305146 @default.
• W4212857529 creator A5082172643 @default.
• W4212857529 creator A5090366405 @default.
• W4212857529 date "2022-03-01" @default.
• W4212857529 modified "2023-10-14" @default.
• W4212857529 title "Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2" @default.
• W4212857529 cites W1487853058 @default.
• W4212857529 cites W1976771127 @default.
• W4212857529 cites W2031016321 @default.
• W4212857529 cites W2082715573 @default.
• W4212857529 cites W2140287290 @default.
• W4212857529 cites W2162798818 @default.
• W4212857529 cites W2265121473 @default.
• W4212857529 cites W2287528634 @default.
• W4212857529 cites W2411125248 @default.
• W4212857529 cites W2749467817 @default.
• W4212857529 cites W2774169295 @default.
• W4212857529 cites W2790040397 @default.
• W4212857529 cites W2792235055 @default.
• W4212857529 cites W2833622183 @default.
• W4212857529 cites W2887216690 @default.
• W4212857529 cites W2904628185 @default.
• W4212857529 cites W2911442500 @default.
• W4212857529 cites W2921575456 @default.
• W4212857529 cites W2926998048 @default.
• W4212857529 cites W2946185807 @default.
• W4212857529 cites W2946464891 @default.
• W4212857529 cites W2960459437 @default.
• W4212857529 cites W2969669738 @default.
• W4212857529 cites W2982510680 @default.
• W4212857529 cites W2990272696 @default.
• W4212857529 cites W2992581289 @default.
• W4212857529 cites W2993347499 @default.
• W4212857529 cites W2994616445 @default.
• W4212857529 cites W2996270784 @default.
• W4212857529 cites W2997236641 @default.
• W4212857529 cites W3002172609 @default.
• W4212857529 cites W3004047335 @default.
• W4212857529 cites W3005104290 @default.
• W4212857529 cites W3007449250 @default.
• W4212857529 cites W3015401968 @default.
• W4212857529 cites W3019745921 @default.
• W4212857529 cites W3020049573 @default.
• W4212857529 cites W3022902771 @default.
• W4212857529 cites W3027229779 @default.
• W4212857529 cites W3028960763 @default.
• W4212857529 cites W3028984613 @default.
• W4212857529 cites W3030691479 @default.
• W4212857529 cites W3037991537 @default.
• W4212857529 cites W3041054968 @default.
• W4212857529 cites W3041716749 @default.
• W4212857529 cites W3045194380 @default.
• W4212857529 cites W3049310976 @default.
• W4212857529 cites W3087276021 @default.
• W4212857529 cites W3096517545 @default.
• W4212857529 cites W3096920871 @default.
• W4212857529 cites W3097037601 @default.
• W4212857529 cites W3098115657 @default.
• W4212857529 cites W3101197848 @default.
• W4212857529 cites W3106439440 @default.
• W4212857529 cites W3107931854 @default.
• W4212857529 cites W3118368464 @default.
• W4212857529 cites W3126965852 @default.
• W4212857529 cites W3127747008 @default.
• W4212857529 cites W3131575773 @default.
• W4212857529 cites W3134337570 @default.
• W4212857529 cites W3149850479 @default.
• W4212857529 cites W3186117366 @default.
• W4212857529 cites W4211017340 @default.
• W4212857529 doi "https://doi.org/10.1016/j.omto.2022.02.008" @default.
• W4212857529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35284624" @default.
• W4212857529 hasPublicationYear "2022" @default.
• W4212857529 type Work @default.
• W4212857529 citedByCount "12" @default.
• W4212857529 countsByYear W42128575292022 @default.
• W4212857529 countsByYear W42128575292023 @default.
• W4212857529 crossrefType "journal-article" @default.

• next