Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212859916> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4212859916 abstract "Peroxisome proliferator-activated receptor gamma (PPARgamma) is the master regulator of adipogenesis as well as the target of thiazolidinedione (TZD) antidiabetic drugs. Many PPARgamma target genes are induced during adipogenesis, but others, such as glycerol kinase (GyK), are expressed at low levels in adipocytes and dramatically up-regulated by TZDs. Here, we have explored the mechanism whereby an exogenous PPARgamma ligand is selectively required for adipocyte gene expression. The GyK gene contains a functional PPARgamma-response element to which endogenous PPARgamma is recruited in adipocytes. However, unlike the classic PPARgamma-target gene aP2, which is constitutively associated with coactivators, the GyK gene is targeted by nuclear receptor corepressors in adipocytes. TZDs trigger the dismissal of corepressor histone deacetylase (HDAC) complexes and the recruitment of coactivators to the GyK gene. TZDs also induce PPARgamma-Coactivator 1alpha (PGC-1alpha), whose recruitment to the GyK gene is sufficient to release the corepressors. Thus, selective modulation of adipocyte PPARgamma target genes by TZDs involves the dissociation of corepressors by direct and indirect mechanisms. PMID: 15681609 Funding information This work was supported by: NIDDK NIH HHS, United States Grant ID: R01 DK049780" @default.
- W4212859916 created "2022-02-24" @default.
- W4212859916 creator A5031784533 @default.
- W4212859916 date "2005-02-16" @default.
- W4212859916 modified "2023-10-05" @default.
- W4212859916 title "Faculty Opinions recommendation of Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes." @default.
- W4212859916 doi "https://doi.org/10.3410/f.1024007.285831" @default.
- W4212859916 hasPublicationYear "2005" @default.
- W4212859916 type Work @default.
- W4212859916 citedByCount "0" @default.
- W4212859916 crossrefType "dataset" @default.
- W4212859916 hasAuthorship W4212859916A5031784533 @default.
- W4212859916 hasBestOaLocation W42128599161 @default.
- W4212859916 hasConcept C104317684 @default.
- W4212859916 hasConcept C122927707 @default.
- W4212859916 hasConcept C126322002 @default.
- W4212859916 hasConcept C134018914 @default.
- W4212859916 hasConcept C146777309 @default.
- W4212859916 hasConcept C170493617 @default.
- W4212859916 hasConcept C171089720 @default.
- W4212859916 hasConcept C185592680 @default.
- W4212859916 hasConcept C187345961 @default.
- W4212859916 hasConcept C2776175234 @default.
- W4212859916 hasConcept C55493867 @default.
- W4212859916 hasConcept C63932345 @default.
- W4212859916 hasConcept C71924100 @default.
- W4212859916 hasConcept C77445288 @default.
- W4212859916 hasConcept C86339819 @default.
- W4212859916 hasConcept C86803240 @default.
- W4212859916 hasConcept C95444343 @default.
- W4212859916 hasConceptScore W4212859916C104317684 @default.
- W4212859916 hasConceptScore W4212859916C122927707 @default.
- W4212859916 hasConceptScore W4212859916C126322002 @default.
- W4212859916 hasConceptScore W4212859916C134018914 @default.
- W4212859916 hasConceptScore W4212859916C146777309 @default.
- W4212859916 hasConceptScore W4212859916C170493617 @default.
- W4212859916 hasConceptScore W4212859916C171089720 @default.
- W4212859916 hasConceptScore W4212859916C185592680 @default.
- W4212859916 hasConceptScore W4212859916C187345961 @default.
- W4212859916 hasConceptScore W4212859916C2776175234 @default.
- W4212859916 hasConceptScore W4212859916C55493867 @default.
- W4212859916 hasConceptScore W4212859916C63932345 @default.
- W4212859916 hasConceptScore W4212859916C71924100 @default.
- W4212859916 hasConceptScore W4212859916C77445288 @default.
- W4212859916 hasConceptScore W4212859916C86339819 @default.
- W4212859916 hasConceptScore W4212859916C86803240 @default.
- W4212859916 hasConceptScore W4212859916C95444343 @default.
- W4212859916 hasLocation W42128599161 @default.
- W4212859916 hasOpenAccess W4212859916 @default.
- W4212859916 hasPrimaryLocation W42128599161 @default.
- W4212859916 hasRelatedWork W2028769116 @default.
- W4212859916 hasRelatedWork W2034247645 @default.
- W4212859916 hasRelatedWork W2049875393 @default.
- W4212859916 hasRelatedWork W2056158185 @default.
- W4212859916 hasRelatedWork W2068895932 @default.
- W4212859916 hasRelatedWork W2118746168 @default.
- W4212859916 hasRelatedWork W2169726677 @default.
- W4212859916 hasRelatedWork W2170714239 @default.
- W4212859916 hasRelatedWork W2896158951 @default.
- W4212859916 hasRelatedWork W3173808450 @default.
- W4212859916 isParatext "false" @default.
- W4212859916 isRetracted "false" @default.
- W4212859916 workType "dataset" @default.