Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212864029> ?p ?o ?g. }
- W4212864029 abstract "Abstract How a single neuronal population diversifies into subtypes with distinct synaptic targets is a fundamental topic in neuroscience whose underlying mechanisms are unclear. Here, we show that the histone H3-lysine 27 demethylase Kdm6b regulates the diversification of motor neurons to distinct subtypes innervating different muscle targets during spinal cord development. In mouse embryonic motor neurons, Kdm6b promotes the medial motor column (MMC) and hypaxial motor column (HMC) fates while inhibiting the lateral motor column (LMC) and preganglionic motor column (PGC) identities. Our single-cell RNA-sequencing analyses reveal the heterogeneity of PGC, LMC, and MMC motor neurons. Further, our single-cell RNA-sequencing data, combined with mouse model studies, demonstrates that Kdm6b acquires cell fate specificity together with the transcription factor complex Isl1-Lhx3. Our study provides mechanistic insight into the gene regulatory network regulating neuronal cell-type diversification and defines a regulatory role of Kdm6b in the generation of motor neuron subtypes in the mouse spinal cord." @default.
- W4212864029 created "2022-02-24" @default.
- W4212864029 creator A5000807789 @default.
- W4212864029 creator A5044665500 @default.
- W4212864029 creator A5063925873 @default.
- W4212864029 creator A5076889644 @default.
- W4212864029 date "2022-02-17" @default.
- W4212864029 modified "2023-10-17" @default.
- W4212864029 title "The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development" @default.
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- W4212864029 doi "https://doi.org/10.1038/s41467-022-28636-7" @default.
- W4212864029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35177643" @default.
- W4212864029 hasPublicationYear "2022" @default.
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