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- W4212872397 abstract "The current standard of serum creatinine and biopsy to monitor allograft health has many limitations. The most significant drawback of the current standard is the lack of sensitivity and specificity to allograft injuries, which are diagnosed only after significant damage to the allograft. Thus, it is of critical need to identify a biomarker that is sensitive and specific to the early detection of allograft injuries. Urine, as the direct renal ultrafiltrate that can be obtained noninvasively, directly reflects intrarenal processes in the allograft at greater accuracy than analysis of peripheral blood. We review transcriptomic, metabolomic, genomic, and proteomic discovery-based approaches to identifying urinary biomarkers for the noninvasive detection of allograft injuries, as well as the use of urine cell-free DNA in the QSant urine assay as a sensitive surrogate for the renal allograft biopsy for rejection diagnosis." @default.
- W4212872397 created "2022-02-24" @default.
- W4212872397 creator A5038067984 @default.
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- W4212872397 date "2022-01-04" @default.
- W4212872397 modified "2023-10-18" @default.
- W4212872397 title "Urinary Biomarkers for Kidney Allograft Injury" @default.
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- W4212872397 doi "https://doi.org/10.1097/tp.0000000000004017" @default.
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