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• W4212879339 endingPage "996" @default.
• W4212879339 startingPage "981" @default.
• W4212879339 abstract "Immune checkpoint inhibitors (ICIs) have advanced the field of cancer immunotherapy in patients by sustaining effector immune cell activity within the tumor microenvironment. However, the approach in general is still faced with issues related to ICI response duration/resistance, treatment eligibility, and safety, which indicates a need for further refinements. As immune checkpoint upregulation is inextricably linked to cancer-induced angiogenesis, newer clinical efforts have demonstrated the feasibility of disrupting both tumor-promoting networks to mediate enhanced immune-driven protection. This review focuses on such key evidence stipulating the necessity of co-applying ICI and anti-angiogenic strategies in cancer patients, with particular interest in highlighting newer engineered antibody approaches that may provide theoretically superior multi-pronged and safe therapeutic combinations." @default.
• W4212879339 created "2022-02-24" @default.
• W4212879339 creator A5037969198 @default.
• W4212879339 creator A5048891817 @default.
• W4212879339 creator A5050022897 @default.
• W4212879339 creator A5073700210 @default.
• W4212879339 creator A5086826588 @default.
• W4212879339 date "2022-11-01" @default.
• W4212879339 modified "2023-10-14" @default.
• W4212879339 title "Disrupting cancer angiogenesis and immune checkpoint networks for improved tumor immunity" @default.
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