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- W4212881036 abstract "In epithelial tissues, the lineage relationship between normal progenitor cells and cell type(s) of origin for cancer has been poorly understood. Here we show that a known regulator of prostate epithelial differentiation, the homeobox gene Nkx3-1, marks a stem cell population that functions during prostate regeneration. Genetic lineage-marking demonstrates that rare luminal cells that express Nkx3-1 in the absence of testicular androgens (castration-resistant Nkx3-1-expressing cells, CARNs) are bipotential and can self-renew in vivo, and single-cell transplantation assays show that CARNs can reconstitute prostate ducts in renal grafts. Functional assays of Nkx3-1 mutant mice in serial prostate regeneration suggest that Nkx3-1 is required for stem cell maintenance. Furthermore, targeted deletion of the Pten tumour suppressor gene in CARNs results in rapid carcinoma formation after androgen-mediated regeneration. These observations indicate that CARNs represent a new luminal stem cell population that is an efficient target for oncogenic transformation in prostate cancer. PMID: 19741607 Funding information This work was supported by: NIDDK NIH HHS, United States Grant ID: R01 DK076602-05 NCI NIH HHS, United States Grant ID: P01 CA154293 NIDDK NIH HHS, United States Grant ID: R01 DK076602 NCI NIH HHS, United States Grant ID: U01 CA084294 NCI NIH HHS, United States Grant ID: U01 CA084294-10" @default.
- W4212881036 created "2022-02-24" @default.
- W4212881036 creator A5000634626 @default.
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- W4212881036 date "2009-10-19" @default.
- W4212881036 modified "2023-09-28" @default.
- W4212881036 title "Faculty Opinions recommendation of A luminal epithelial stem cell that is a cell of origin for prostate cancer." @default.
- W4212881036 doi "https://doi.org/10.3410/f.1165162.628455" @default.
- W4212881036 hasPublicationYear "2009" @default.
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