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- W4212897639 abstract "Abstract Purpose The primary purpose of our study is to determine the accuracy and consistency of different evaluation systems including APACHE II scoring system and Survival After Veno-arterial ECMO (SAVE) score on predicting the prognosis of adult patients with ECPR. Methods We reviewed 74 adult patients underwent ECPR from June 2016 to July 2021. The primary endpoint examined was survival at hospital discharge or 28 days. The predicted accuracy of SAVE and APACHE II scoring systems was evaluated by binary logistic analysis and ROC curve, and the predicted consistency of the two grading systems was evaluated by Bland Altman plots. Results Overall, 43 (58.1%) patients finally died. On multivariable analysis, APACHE II score (OR = 1.372, 95%CI: 1.056–1.782, P = 0.018) was independently associated with increased 28-day mortality. The variable independently associated with decreased 28-day mortality included increased SAVE score (OR = 0.757, 95%CI: 0.643–0.890, P = 0.001). ROC analysis showed cut-off values to predict 28-day mortality for APACHE II score, namely 35.5 (sensitivity 79.1%, specificity 74.1%, AUC 0.81, 95%CI: 0.70–0.91), for SAVE score, namely − 6.5 (sensitivity 61.1%, specificity 83.7%, AUC 0.86, 95%CI:0.78–0.95), combined multivariate ROC analysis of both two parameters showed an AUC of 0.90 (95%CI: 0.83–0.97). In the Bland Altman plot for ECPR, mean mortality APAHCE II was not statistically different from mean mortality SAVE (P = 0.99, mean difference mortality APAHCE II -mortality SAVE =0.00%, 95%CI: -6.89–6.89%), meanwhile APACHE II and SAVE agreed well (95% limit of agreement:-59.29–59.29%) . Conclusion APACHE II and SAVE scores were fairly accurate in predicting prevention in adult ECPR patients and the predictive results of the two scoring systems are highly consistent." @default.
- W4212897639 created "2022-02-24" @default.
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- W4212897639 date "2022-02-17" @default.
- W4212897639 modified "2023-09-29" @default.
- W4212897639 title "Prognostic value of APACHE II and SAVE scores in adult patients treated with extracorporeal cardiopulmonary resuscitation" @default.
- W4212897639 doi "https://doi.org/10.21203/rs.3.rs-1348268/v1" @default.
- W4212897639 hasPublicationYear "2022" @default.
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