Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212904698> ?p ?o ?g. }
- W4212904698 endingPage "273" @default.
- W4212904698 startingPage "264" @default.
- W4212904698 abstract "Gray matter abnormalities are observed across the psychosis spectrum. The trajectory of these abnormalities in healthy adolescents reporting subthreshold psychotic experiences (PEs) may provide insight into the neural mechanisms underlying psychotic symptoms. The risk of psychosis and additional psychopathology is even higher among these individuals who also report childhood adversity/DSM-5 diagnoses. Thus, the aims of this longitudinal study were to investigate PE-related volumetric changes in young people, noting any effects of childhood adversity/DSM-5 diagnosis.A total of 211 young people 11 to 13 years of age participated in the initial Adolescent Brain Development study. PE classification was determined by expert consensus at each time point. Participants underwent neuroimaging at 3 time points over 6 years. A total of 76 participants with at least one scan were included in the final sample; 34 who met criteria for PEs at least once across all the time points (PE group) and 42 control subjects. Data from 20 bilateral regions of interest were extracted for linear mixed-effects analyses.Right hippocampal volume increased over time in the control group, with no increase in the PE group (p = .00352). DSM-5 diagnosis and childhood adversity were not significantly associated with right hippocampal volume. There was no significant effect of group or interaction in any other region.These findings further implicate right hippocampal volumetric abnormalities in the pathophysiology underlying PEs. Furthermore, as suggested by previous studies in those at clinical high risk for psychosis and those with first-episode psychosis, it is possible that these deficits may be a marker for later clinical outcomes." @default.
- W4212904698 created "2022-02-24" @default.
- W4212904698 creator A5006791816 @default.
- W4212904698 creator A5022070906 @default.
- W4212904698 creator A5043918876 @default.
- W4212904698 creator A5048558289 @default.
- W4212904698 creator A5052297091 @default.
- W4212904698 creator A5059787212 @default.
- W4212904698 creator A5071717308 @default.
- W4212904698 creator A5083172243 @default.
- W4212904698 date "2023-04-01" @default.
- W4212904698 modified "2023-10-18" @default.
- W4212904698 title "Longitudinal Gray Matter Development Associated With Psychotic Experiences in Young People" @default.
- W4212904698 cites W1876943069 @default.
- W4212904698 cites W1881223776 @default.
- W4212904698 cites W1965374197 @default.
- W4212904698 cites W1980583247 @default.
- W4212904698 cites W1980862554 @default.
- W4212904698 cites W1983302342 @default.
- W4212904698 cites W1984141645 @default.
- W4212904698 cites W2004293194 @default.
- W4212904698 cites W2005933475 @default.
- W4212904698 cites W2012364225 @default.
- W4212904698 cites W2021753575 @default.
- W4212904698 cites W2024000940 @default.
- W4212904698 cites W2033166913 @default.
- W4212904698 cites W2045716255 @default.
- W4212904698 cites W2047051692 @default.
- W4212904698 cites W2069533264 @default.
- W4212904698 cites W2087849720 @default.
- W4212904698 cites W2090004063 @default.
- W4212904698 cites W2090530553 @default.
- W4212904698 cites W2097940171 @default.
- W4212904698 cites W2102039518 @default.
- W4212904698 cites W2103481737 @default.
- W4212904698 cites W2109252219 @default.
- W4212904698 cites W2110208125 @default.
- W4212904698 cites W2110437310 @default.
- W4212904698 cites W2112272714 @default.
- W4212904698 cites W2112406414 @default.
- W4212904698 cites W2113319997 @default.
- W4212904698 cites W2117591375 @default.
- W4212904698 cites W2121369614 @default.
- W4212904698 cites W2122546061 @default.
- W4212904698 cites W2122792759 @default.
- W4212904698 cites W2129291386 @default.
- W4212904698 cites W2130175630 @default.
- W4212904698 cites W2136435696 @default.
- W4212904698 cites W2139886607 @default.
- W4212904698 cites W2150487695 @default.
- W4212904698 cites W2151130155 @default.
- W4212904698 cites W2151721316 @default.
- W4212904698 cites W2153549503 @default.
- W4212904698 cites W2154079631 @default.
- W4212904698 cites W2155963684 @default.
- W4212904698 cites W2159928053 @default.
- W4212904698 cites W2160448378 @default.
- W4212904698 cites W2167664297 @default.
- W4212904698 cites W2172148141 @default.
- W4212904698 cites W2200714057 @default.
- W4212904698 cites W2301077564 @default.
- W4212904698 cites W2507739722 @default.
- W4212904698 cites W2523665179 @default.
- W4212904698 cites W2531297282 @default.
- W4212904698 cites W2580699946 @default.
- W4212904698 cites W2590133125 @default.
- W4212904698 cites W2599264051 @default.
- W4212904698 cites W2611301184 @default.
- W4212904698 cites W2625014634 @default.
- W4212904698 cites W2735511385 @default.
- W4212904698 cites W2783894827 @default.
- W4212904698 cites W2787945422 @default.
- W4212904698 cites W2789470834 @default.
- W4212904698 cites W2794809708 @default.
- W4212904698 cites W2800546828 @default.
- W4212904698 cites W2809866414 @default.
- W4212904698 cites W2886909681 @default.
- W4212904698 cites W2889057753 @default.
- W4212904698 cites W2890853008 @default.
- W4212904698 cites W2902336461 @default.
- W4212904698 cites W2902815504 @default.
- W4212904698 cites W2902921748 @default.
- W4212904698 cites W2911788227 @default.
- W4212904698 cites W2945513460 @default.
- W4212904698 cites W2946523981 @default.
- W4212904698 cites W2952709054 @default.
- W4212904698 cites W2972212755 @default.
- W4212904698 cites W2978685810 @default.
- W4212904698 cites W2980717706 @default.
- W4212904698 cites W2984865037 @default.
- W4212904698 cites W2986902715 @default.
- W4212904698 cites W2997948039 @default.
- W4212904698 cites W3006481709 @default.
- W4212904698 cites W3007560027 @default.
- W4212904698 cites W3013111324 @default.
- W4212904698 cites W3013355287 @default.
- W4212904698 cites W3026571998 @default.
- W4212904698 cites W3028661271 @default.