Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212911412> ?p ?o ?g. }
- W4212911412 endingPage "647" @default.
- W4212911412 startingPage "637" @default.
- W4212911412 abstract "Shared epitope (SE) is present in high proportions of anti-citrullinated protein antibody (ACPA) + patients with rheumatoid arthritis (RA) and is associated with poor prognosis. We assessed the role of SE in RA prognosis, in relation to ACPA positivity.Patients enrolled in the Brigham and Women's RA Sequential Study were included. Changes from baseline in disease activity (Disease Activity Score in 28 joints using C-reactive protein [DAS28 (CRP)], Clinical Disease Activity Index [CDAI], Simplified Disease Activity Index [SDAI]) to 1 year were assessed. Baseline characteristics were compared by SE and ACPA status (±; chi-squared, Kruskal-Wallis). Association between number of SE alleles and ACPA status (logistic regression models), relationships between baseline characteristics and changes in disease activity (adjusted linear regression model), and effect of ACPA on the association between SE and changes in disease activity (mediation analysis) were studied.Nine hundred twenty-six patients were included. SE + versus SE - patients had significantly longer disease duration and higher disease activity scores and were more likely to have erosive disease, have higher comorbidity burden, and be RF + (all p < 0.05). Among patients with one or two SE alleles (vs. 0), odds of being ACPA + were 1.97 (p = 0.0003) and 3.82 (p < 0.0001), respectively. SE + versus SE - patients had worse disease activity scores as indicated by mean increases in DAS28 (CRP) of 0.22, CDAI of 2.07, and SDAI of 2.43 over 1 year (all p < 0.05). Direct effect of SE + accounted for 76.4-80.1% of total effect in disease activity increases.SE is strongly associated with ACPA positivity and higher disease activity in patients with RA. SE was associated with greater increases in disease activity over 1 year, which was partially mediated by the presence of ACPA.ClinicalTrials.gov identifier: NCT01793103; registration date: February 15, 2013, retrospectively registered.Patients with rheumatoid arthritis (RA) experience inflamed and damaged joints. RA is an autoimmune disease where proteins called autoantibodies in the blood of patients with RA target the patient’s own joint tissue and organs by mistake. This causes inflammation. Patients with certain autoantibodies, such as anti-citrullinated protein antibodies (ACPAs), may experience worse symptoms. There are certain genetic risk factors that may mean a person is more likely to develop RA. One example of a genetic risk factor is having the shared epitope (SE).Our study looked at almost 1000 patients with RA in the general population. It explored the impact of having SE and ACPAs on changes in RA disease activity. Patients with SE had RA for a longer time, had more severe disease, and were more likely to have other diseases compared with patients without SE. Patients with SE were also more likely to have ACPAs. Over the course of one year, patients with SE had larger increases in RA disease activity than those patients without SE, even though they were taking the same treatments. These results suggest that patients with the genetic risk factor, SE often have RA that is harder to treat. Doctors should take this into account when selecting treatment for RA." @default.
- W4212911412 created "2022-02-24" @default.
- W4212911412 creator A5002326322 @default.
- W4212911412 creator A5020233946 @default.
- W4212911412 creator A5027345808 @default.
- W4212911412 creator A5047117557 @default.
- W4212911412 creator A5056574191 @default.
- W4212911412 creator A5069114837 @default.
- W4212911412 creator A5070573117 @default.
- W4212911412 creator A5077495991 @default.
- W4212911412 creator A5081306729 @default.
- W4212911412 date "2022-02-16" @default.
- W4212911412 modified "2023-10-18" @default.
- W4212911412 title "The Role of Shared Epitope in Rheumatoid Arthritis Prognosis in Relation to Anti-Citrullinated Protein Antibody Positivity" @default.
- W4212911412 cites W1682106530 @default.
- W4212911412 cites W1835996108 @default.
- W4212911412 cites W1964890547 @default.
- W4212911412 cites W1968889356 @default.
- W4212911412 cites W1996611544 @default.
- W4212911412 cites W2015865604 @default.
- W4212911412 cites W2016370312 @default.
- W4212911412 cites W2024988150 @default.
- W4212911412 cites W2025408360 @default.
- W4212911412 cites W2061747384 @default.
- W4212911412 cites W2110826367 @default.
- W4212911412 cites W2113834933 @default.
- W4212911412 cites W2122249518 @default.
- W4212911412 cites W2138961086 @default.
- W4212911412 cites W2147514926 @default.
- W4212911412 cites W2152348310 @default.
- W4212911412 cites W2159956751 @default.
- W4212911412 cites W2325883627 @default.
- W4212911412 cites W2417649976 @default.
- W4212911412 cites W2560381583 @default.
- W4212911412 cites W2615680896 @default.
- W4212911412 cites W2749404643 @default.
- W4212911412 cites W2759236476 @default.
- W4212911412 cites W2762730732 @default.
- W4212911412 cites W2766047656 @default.
- W4212911412 cites W2783475872 @default.
- W4212911412 cites W3042731161 @default.
- W4212911412 cites W3214776682 @default.
- W4212911412 cites W4211054359 @default.
- W4212911412 cites W4231972505 @default.
- W4212911412 doi "https://doi.org/10.1007/s40744-022-00427-y" @default.
- W4212911412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35174462" @default.
- W4212911412 hasPublicationYear "2022" @default.
- W4212911412 type Work @default.
- W4212911412 citedByCount "2" @default.
- W4212911412 countsByYear W42129114122023 @default.
- W4212911412 crossrefType "journal-article" @default.
- W4212911412 hasAuthorship W4212911412A5002326322 @default.
- W4212911412 hasAuthorship W4212911412A5020233946 @default.
- W4212911412 hasAuthorship W4212911412A5027345808 @default.
- W4212911412 hasAuthorship W4212911412A5047117557 @default.
- W4212911412 hasAuthorship W4212911412A5056574191 @default.
- W4212911412 hasAuthorship W4212911412A5069114837 @default.
- W4212911412 hasAuthorship W4212911412A5070573117 @default.
- W4212911412 hasAuthorship W4212911412A5077495991 @default.
- W4212911412 hasAuthorship W4212911412A5081306729 @default.
- W4212911412 hasBestOaLocation W42129114121 @default.
- W4212911412 hasConcept C126322002 @default.
- W4212911412 hasConcept C151956035 @default.
- W4212911412 hasConcept C156957248 @default.
- W4212911412 hasConcept C159654299 @default.
- W4212911412 hasConcept C203014093 @default.
- W4212911412 hasConcept C2776232647 @default.
- W4212911412 hasConcept C2776914184 @default.
- W4212911412 hasConcept C2777575956 @default.
- W4212911412 hasConcept C2779134260 @default.
- W4212911412 hasConcept C2779159551 @default.
- W4212911412 hasConcept C2781195455 @default.
- W4212911412 hasConcept C71924100 @default.
- W4212911412 hasConcept C90924648 @default.
- W4212911412 hasConceptScore W4212911412C126322002 @default.
- W4212911412 hasConceptScore W4212911412C151956035 @default.
- W4212911412 hasConceptScore W4212911412C156957248 @default.
- W4212911412 hasConceptScore W4212911412C159654299 @default.
- W4212911412 hasConceptScore W4212911412C203014093 @default.
- W4212911412 hasConceptScore W4212911412C2776232647 @default.
- W4212911412 hasConceptScore W4212911412C2776914184 @default.
- W4212911412 hasConceptScore W4212911412C2777575956 @default.
- W4212911412 hasConceptScore W4212911412C2779134260 @default.
- W4212911412 hasConceptScore W4212911412C2779159551 @default.
- W4212911412 hasConceptScore W4212911412C2781195455 @default.
- W4212911412 hasConceptScore W4212911412C71924100 @default.
- W4212911412 hasConceptScore W4212911412C90924648 @default.
- W4212911412 hasIssue "2" @default.
- W4212911412 hasLocation W42129114121 @default.
- W4212911412 hasLocation W42129114122 @default.
- W4212911412 hasLocation W42129114123 @default.
- W4212911412 hasOpenAccess W4212911412 @default.
- W4212911412 hasPrimaryLocation W42129114121 @default.
- W4212911412 hasRelatedWork W1523098566 @default.
- W4212911412 hasRelatedWork W1963511249 @default.
- W4212911412 hasRelatedWork W2031170496 @default.
- W4212911412 hasRelatedWork W2136925628 @default.
- W4212911412 hasRelatedWork W2273279881 @default.