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- W4212912658 abstract "Bioanalysis requires use of various methods for monitoring of both endogenous species and xenobiotics in biological materials. Sample complexity, high diversity of analytes, and often low concentrations call for methods with high selectivity and sensitivity. Supercritical fluid chromatography coupled to mass spectrometry (SFC-MS) has established itself as an important alternative technique in addition to more traditional high-performance liquid chromatography and gas chromatography. A significant increase in interest for SFC-MS applied in bioanalytical field is observed particularly since the introduction of novel SFC instrumentation that provides robust platform, meeting the rigorous criteria of method validation in strictly regulated environment. SFC-MS has demonstrated many benefits in a wide range of specific applications such as analysis of drugs and their metabolites, analysis of chiral drugs, doping screening and analysis of drugs of abuse, analysis of fat-soluble vitamins and carotenoids, and, finally, in metabolomics concerning mostly lipidomic analyses." @default.
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- W4212912658 date "2018-12-17" @default.
- W4212912658 modified "2023-09-23" @default.
- W4212912658 title "2. Supercritical fluid chromatography in bioanalysis" @default.
- W4212912658 doi "https://doi.org/10.1515/9783110618983-002" @default.
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