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• W4212933133 endingPage "1638" @default.
• W4212933133 startingPage "1638" @default.
• W4212933133 abstract "Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid with multiple functions conveyed by the activation of cell surface receptors and/or intracellular mediators. A growing body of evidence indicates its important role in pancreatic insulin-secreting beta-cells that are necessary for maintenance of glucose homeostasis. The dysfunction and/or death of beta-cells lead to diabetes development. Diabetes is a serious public health burden with incidence growing rapidly in recent decades. The two major types of diabetes are the autoimmune-mediated type 1 diabetes (T1DM) and the metabolic stress-related type 2 diabetes (T2DM). Despite many differences in the development, both types of diabetes are characterized by chronic hyperglycemia and inflammation. The inflammatory component of diabetes remains under-characterized. Recent years have brought new insights into the possible mechanism involved in the increased inflammatory response, suggesting that environmental factors such as a westernized diet may participate in this process. Dietary lipids, particularly palmitate, are substrates for the biosynthesis of bioactive sphingolipids. Disturbed serum sphingolipid profiles were observed in both T1DM and T2DM patients. Many polymorphisms were identified in genes encoding enzymes of the sphingolipid pathway, including sphingosine kinase 2 (SK2), the S1P generating enzyme which is highly expressed in beta-cells. Proinflammatory cytokines and free fatty acids have been shown to modulate the expression and activity of S1P-generating and S1P-catabolizing enzymes. In this review, the similarities and differences in the action of extracellular and intracellular S1P in beta-cells exposed to cytokines or free fatty acids will be identified and the outlook for future research will be discussed." @default.
• W4212933133 created "2022-02-24" @default.
• W4212933133 creator A5055352916 @default.
• W4212933133 date "2022-01-31" @default.
• W4212933133 modified "2023-10-09" @default.
• W4212933133 title "To Be or Not to Be: The Divergent Action and Metabolism of Sphingosine-1 Phosphate in Pancreatic Beta-Cells in Response to Cytokines and Fatty Acids" @default.
• W4212933133 cites W1537983046 @default.
• W4212933133 cites W1599581161 @default.
• W4212933133 cites W1608842679 @default.
• W4212933133 cites W1846971709 @default.
• W4212933133 cites W1929373940 @default.
• W4212933133 cites W1963632908 @default.
• W4212933133 cites W1965382258 @default.
• W4212933133 cites W1967567839 @default.
• W4212933133 cites W1967827418 @default.
• W4212933133 cites W1971250081 @default.
• W4212933133 cites W1976246664 @default.
• W4212933133 cites W1979930201 @default.
• W4212933133 cites W1980553725 @default.
• W4212933133 cites W1981231681 @default.
• W4212933133 cites W1981794893 @default.
• W4212933133 cites W1982511080 @default.
• W4212933133 cites W1982671158 @default.
• W4212933133 cites W1982965514 @default.
• W4212933133 cites W1985224052 @default.
• W4212933133 cites W1986394981 @default.
• W4212933133 cites W1988819271 @default.
• W4212933133 cites W1991801582 @default.
• W4212933133 cites W1991899733 @default.
• W4212933133 cites W1994567337 @default.
• W4212933133 cites W1995139895 @default.
• W4212933133 cites W1995982280 @default.
• W4212933133 cites W1996605319 @default.
• W4212933133 cites W1999220854 @default.
• W4212933133 cites W2003524154 @default.
• W4212933133 cites W2003688815 @default.
• W4212933133 cites W2003752656 @default.
• W4212933133 cites W2006639171 @default.
• W4212933133 cites W2006740199 @default.
• W4212933133 cites W2013825614 @default.
• W4212933133 cites W2018180869 @default.
• W4212933133 cites W2018729128 @default.
• W4212933133 cites W2018866981 @default.
• W4212933133 cites W2022770236 @default.
• W4212933133 cites W2025646741 @default.
• W4212933133 cites W2028408624 @default.
• W4212933133 cites W2030438495 @default.
• W4212933133 cites W2034385545 @default.
• W4212933133 cites W2034607874 @default.
• W4212933133 cites W2034610919 @default.
• W4212933133 cites W2035339090 @default.
• W4212933133 cites W2042753405 @default.
• W4212933133 cites W2044725265 @default.
• W4212933133 cites W2048749392 @default.
• W4212933133 cites W2049675115 @default.
• W4212933133 cites W2054489926 @default.
• W4212933133 cites W2058553382 @default.
• W4212933133 cites W2060290354 @default.
• W4212933133 cites W2061457959 @default.
• W4212933133 cites W2063335978 @default.
• W4212933133 cites W2066785172 @default.
• W4212933133 cites W2067472269 @default.
• W4212933133 cites W2068796054 @default.
• W4212933133 cites W2070558403 @default.
• W4212933133 cites W2071288349 @default.
• W4212933133 cites W2072116000 @default.
• W4212933133 cites W2072738635 @default.
• W4212933133 cites W2074814583 @default.
• W4212933133 cites W2075195369 @default.
• W4212933133 cites W2075409137 @default.
• W4212933133 cites W2076340271 @default.
• W4212933133 cites W2076738925 @default.
• W4212933133 cites W2079910432 @default.
• W4212933133 cites W2083664211 @default.
• W4212933133 cites W2086782603 @default.
• W4212933133 cites W2089934054 @default.
• W4212933133 cites W2093090129 @default.
• W4212933133 cites W2093962172 @default.
• W4212933133 cites W2096751053 @default.
• W4212933133 cites W2098151578 @default.
• W4212933133 cites W2099792211 @default.
• W4212933133 cites W2101264007 @default.
• W4212933133 cites W2101268659 @default.
• W4212933133 cites W2101791909 @default.
• W4212933133 cites W2108091182 @default.
• W4212933133 cites W2108525739 @default.
• W4212933133 cites W2112530229 @default.
• W4212933133 cites W2114730229 @default.
• W4212933133 cites W2116313215 @default.
• W4212933133 cites W2116341867 @default.
• W4212933133 cites W2116659915 @default.
• W4212933133 cites W2118140893 @default.
• W4212933133 cites W2125112185 @default.
• W4212933133 cites W2125352391 @default.
• W4212933133 cites W2125871871 @default.
• W4212933133 cites W2127520830 @default.
• W4212933133 cites W2127681115 @default.
• W4212933133 cites W2130073922 @default.

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