FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212936729> ?p ?o ?g. }

• W4212936729 endingPage "462" @default.
• W4212936729 startingPage "462" @default.
• W4212936729 abstract "462 Background: Retrospective studies using large registries comparing outcomes between radical cystectomy (RC) with or without neoadjuvant chemotherapy (NAC) to trimodality therapy (TMT), which includes transurethral resection of bladder tumor followed by chemoradiation, often cannot distinguish whether patients receiving TMT were eligible for cystectomy but declined or simply ineligible for cystectomy. The objective of this study was to compare survival outcomes of patients with MIBC receiving TMT stratified by whether they were cystectomy-eligible to patients receiving RC +/- NAC. Methods: We used the national Veterans Affairs’ (VA) database to identify patients diagnosed between 2000-2017 with urothelial histology, MIBC (T2-4a/N0-3/M0) who underwent RC or TMT. Overall survival (OS) was evaluated with multivariable Cox proportional hazards model. Bladder cancer-specific mortality (BCSM) was evaluated with multivariable Fine-Gray regression. We conducted a chart review of clinical notes to ascertain if patients were eligible for cystectomy. Results: Overall 2306 Veterans with MIBC were included: 1472 (64%) with RC without NAC, 506 (22%) with RC-NAC, 107 (4.6%) with TMT eligible for RC, and 221 (9.4%) with TMT ineligible for RC. Median follow up time was 4.7 years. Patients receiving RC were on average 10 years younger, had higher creatinine clearance, and fewer comorbidities than those receiving TMT. Cystectomy-eligible TMT patients had higher creatinine clearance and fewer comorbidities than those ineligible for cystectomy. On multivariable analysis, compared to RC-NAC, TMT in cystectomy-eligible patients was associated with similar OS (hazard ratio [HR] 0.99; 95% confidence interval [CI] 0.76 - 1.28; p = 0.93) and BCSM (HR 1.02; 95% CI 0.71-1.47; p = 0.91). Compared to RC-NAC, TMT in cystectomy-ineligible patients was associated with inferior OS (HR 1.39; 95% CI 1.13 - 1.71; p = 0.002) and BCSM (HR 1.61; 95% CI 1.23 - 2.10; p < 0.001). Conclusions: There is a significant selection bias among patients with MIBC receiving TMT. Cystectomy-eligible patients receiving TMT likely have similar survival outcomes as those receiving RC. Comparisons between RC and TMT in large registry data that lack information regarding eligibility for cystectomy in the TMT arm may be unreliable." @default.
• W4212936729 created "2022-02-24" @default.
• W4212936729 creator A5004819903 @default.
• W4212936729 creator A5043763331 @default.
• W4212936729 creator A5044071754 @default.
• W4212936729 creator A5058325420 @default.
• W4212936729 creator A5059026108 @default.
• W4212936729 creator A5083199205 @default.
• W4212936729 creator A5091329688 @default.
• W4212936729 date "2022-02-20" @default.
• W4212936729 modified "2023-09-27" @default.
• W4212936729 title "Impact of selection bias on outcomes in veterans with muscle-invasive bladder cancer receiving bladder preserving trimodality therapy." @default.
• W4212936729 doi "https://doi.org/10.1200/jco.2022.40.6_suppl.462" @default.
• W4212936729 hasPublicationYear "2022" @default.
• W4212936729 type Work @default.
• W4212936729 citedByCount "0" @default.
• W4212936729 crossrefType "journal-article" @default.
• W4212936729 hasAuthorship W4212936729A5004819903 @default.
• W4212936729 hasAuthorship W4212936729A5043763331 @default.
• W4212936729 hasAuthorship W4212936729A5044071754 @default.
• W4212936729 hasAuthorship W4212936729A5058325420 @default.
• W4212936729 hasAuthorship W4212936729A5059026108 @default.
• W4212936729 hasAuthorship W4212936729A5083199205 @default.
• W4212936729 hasAuthorship W4212936729A5091329688 @default.
• W4212936729 hasConcept C121608353 @default.
• W4212936729 hasConcept C126322002 @default.
• W4212936729 hasConcept C126894567 @default.
• W4212936729 hasConcept C143998085 @default.
• W4212936729 hasConcept C167135981 @default.
• W4212936729 hasConcept C207103383 @default.
• W4212936729 hasConcept C2775910329 @default.
• W4212936729 hasConcept C2775969662 @default.
• W4212936729 hasConcept C2780352672 @default.
• W4212936729 hasConcept C44249647 @default.
• W4212936729 hasConcept C50382708 @default.
• W4212936729 hasConcept C71924100 @default.
• W4212936729 hasConceptScore W4212936729C121608353 @default.
• W4212936729 hasConceptScore W4212936729C126322002 @default.
• W4212936729 hasConceptScore W4212936729C126894567 @default.
• W4212936729 hasConceptScore W4212936729C143998085 @default.
• W4212936729 hasConceptScore W4212936729C167135981 @default.
• W4212936729 hasConceptScore W4212936729C207103383 @default.
• W4212936729 hasConceptScore W4212936729C2775910329 @default.
• W4212936729 hasConceptScore W4212936729C2775969662 @default.
• W4212936729 hasConceptScore W4212936729C2780352672 @default.
• W4212936729 hasConceptScore W4212936729C44249647 @default.
• W4212936729 hasConceptScore W4212936729C50382708 @default.
• W4212936729 hasConceptScore W4212936729C71924100 @default.
• W4212936729 hasFunder F4320332161 @default.
• W4212936729 hasIssue "6_suppl" @default.
• W4212936729 hasLocation W42129367291 @default.
• W4212936729 hasOpenAccess W4212936729 @default.
• W4212936729 hasPrimaryLocation W42129367291 @default.
• W4212936729 hasRelatedWork W1562998603 @default.
• W4212936729 hasRelatedWork W2563593363 @default.
• W4212936729 hasRelatedWork W2573303451 @default.
• W4212936729 hasRelatedWork W2605794623 @default.
• W4212936729 hasRelatedWork W2765116280 @default.
• W4212936729 hasRelatedWork W2789722324 @default.
• W4212936729 hasRelatedWork W2890190580 @default.
• W4212936729 hasRelatedWork W2972870493 @default.
• W4212936729 hasRelatedWork W3008603272 @default.
• W4212936729 hasRelatedWork W3037879892 @default.
• W4212936729 hasVolume "40" @default.
• W4212936729 isParatext "false" @default.
• W4212936729 isRetracted "false" @default.
• W4212936729 workType "article" @default.