Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212944775> ?p ?o ?g. }
- W4212944775 endingPage "768" @default.
- W4212944775 startingPage "760" @default.
- W4212944775 abstract "Sanguinarine (SAG), a natural benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis Linn. (Bloodroot), possesses a potential anticancer activity. Lung carcinoma is the chief cause of malignancy-related mortality in China. Non-small cell lung carcinoma (NSCLC) is the main subtype of lung carcinoma and accounts for about eighty-five percent of this disease. Current treatment in controlling and curing NSCLC remains deficient.The role and underlying mechanism of SAG in repressing the growth and metastasis of NSCLC was explored.The role of SAG in regulating the proliferation and invasion of NSCLC cells was evaluated in vitro and in a xenograft model. After treatment with SAG, Fe2+ concentration, reactive oxygen species (ROS) levels, malondialdehyde (MDA), and glutathione (GSH) content in NSCLC cells were assessed to evaluate the effect of SAG on facilitating ferroptosis.SAG exhibited a dose- and time- dependent cytotoxicity in A549 and H3122 cells. SAG treatment effectively repressed the growth and metastasis of NSCLC in a xenograft model. We for the first time verified that SAG triggered ferroptosis of NSCLC cells, as evidenced by increased Fe2+ concentration, ROS level, and MDA content, and decreased GSH content. Mechanistically, SAG decreased the protein stability of glutathione peroxide 4 (GPX4) through E3 ligase STUB1-mediated ubiquitination and degradation of endogenous GPX4. GPX4 overexpression restored the proliferation and invasion of NSCLC cells treated with SAG through inhibiting ferroptosis.SAG inhibits the growth and metastasis of NSCLC by regulating STUB1/GPX4-dependent ferroptosis." @default.
- W4212944775 created "2022-02-24" @default.
- W4212944775 creator A5004957402 @default.
- W4212944775 creator A5006067740 @default.
- W4212944775 creator A5011877804 @default.
- W4212944775 creator A5014859545 @default.
- W4212944775 creator A5023519598 @default.
- W4212944775 creator A5046575186 @default.
- W4212944775 creator A5049686066 @default.
- W4212944775 creator A5072887888 @default.
- W4212944775 creator A5073581773 @default.
- W4212944775 date "2022-03-01" @default.
- W4212944775 modified "2023-09-23" @default.
- W4212944775 title "Sanguinarine Represses the Growth and Metastasis of Non-small Cell Lung Cancer by Facilitating Ferroptosis" @default.
- W4212944775 cites W1909888178 @default.
- W4212944775 cites W1966018626 @default.
- W4212944775 cites W1999307291 @default.
- W4212944775 cites W2002685120 @default.
- W4212944775 cites W2006382528 @default.
- W4212944775 cites W2041315007 @default.
- W4212944775 cites W2065767227 @default.
- W4212944775 cites W2088581521 @default.
- W4212944775 cites W2107277218 @default.
- W4212944775 cites W2114586963 @default.
- W4212944775 cites W2117181237 @default.
- W4212944775 cites W2118411712 @default.
- W4212944775 cites W2140325148 @default.
- W4212944775 cites W2238799256 @default.
- W4212944775 cites W2265062179 @default.
- W4212944775 cites W2549428458 @default.
- W4212944775 cites W2586030734 @default.
- W4212944775 cites W2594946449 @default.
- W4212944775 cites W2922877278 @default.
- W4212944775 cites W2932111434 @default.
- W4212944775 cites W2947494849 @default.
- W4212944775 cites W3009103168 @default.
- W4212944775 cites W3014057928 @default.
- W4212944775 cites W3017703621 @default.
- W4212944775 cites W3022263550 @default.
- W4212944775 cites W3039079886 @default.
- W4212944775 cites W3121485073 @default.
- W4212944775 cites W3126268375 @default.
- W4212944775 cites W3127839532 @default.
- W4212944775 cites W3128089554 @default.
- W4212944775 cites W3134840300 @default.
- W4212944775 cites W3135213615 @default.
- W4212944775 cites W3135962131 @default.
- W4212944775 cites W3139004533 @default.
- W4212944775 cites W3141277978 @default.
- W4212944775 cites W3147852499 @default.
- W4212944775 cites W3149076754 @default.
- W4212944775 cites W3154519849 @default.
- W4212944775 cites W4234236664 @default.
- W4212944775 doi "https://doi.org/10.2174/1381612828666220217124542" @default.
- W4212944775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35176976" @default.
- W4212944775 hasPublicationYear "2022" @default.
- W4212944775 type Work @default.
- W4212944775 citedByCount "8" @default.
- W4212944775 countsByYear W42129447752022 @default.
- W4212944775 countsByYear W42129447752023 @default.
- W4212944775 crossrefType "journal-article" @default.
- W4212944775 hasAuthorship W4212944775A5004957402 @default.
- W4212944775 hasAuthorship W4212944775A5006067740 @default.
- W4212944775 hasAuthorship W4212944775A5011877804 @default.
- W4212944775 hasAuthorship W4212944775A5014859545 @default.
- W4212944775 hasAuthorship W4212944775A5023519598 @default.
- W4212944775 hasAuthorship W4212944775A5046575186 @default.
- W4212944775 hasAuthorship W4212944775A5049686066 @default.
- W4212944775 hasAuthorship W4212944775A5072887888 @default.
- W4212944775 hasAuthorship W4212944775A5073581773 @default.
- W4212944775 hasConcept C121608353 @default.
- W4212944775 hasConcept C126322002 @default.
- W4212944775 hasConcept C185592680 @default.
- W4212944775 hasConcept C2776256026 @default.
- W4212944775 hasConcept C2777667214 @default.
- W4212944775 hasConcept C2778046504 @default.
- W4212944775 hasConcept C2779013556 @default.
- W4212944775 hasConcept C48349386 @default.
- W4212944775 hasConcept C502942594 @default.
- W4212944775 hasConcept C55493867 @default.
- W4212944775 hasConcept C62112901 @default.
- W4212944775 hasConcept C71240020 @default.
- W4212944775 hasConcept C71924100 @default.
- W4212944775 hasConcept C81729549 @default.
- W4212944775 hasConcept C86803240 @default.
- W4212944775 hasConcept C98274493 @default.
- W4212944775 hasConceptScore W4212944775C121608353 @default.
- W4212944775 hasConceptScore W4212944775C126322002 @default.
- W4212944775 hasConceptScore W4212944775C185592680 @default.
- W4212944775 hasConceptScore W4212944775C2776256026 @default.
- W4212944775 hasConceptScore W4212944775C2777667214 @default.
- W4212944775 hasConceptScore W4212944775C2778046504 @default.
- W4212944775 hasConceptScore W4212944775C2779013556 @default.
- W4212944775 hasConceptScore W4212944775C48349386 @default.
- W4212944775 hasConceptScore W4212944775C502942594 @default.
- W4212944775 hasConceptScore W4212944775C55493867 @default.
- W4212944775 hasConceptScore W4212944775C62112901 @default.
- W4212944775 hasConceptScore W4212944775C71240020 @default.