Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212946215> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4212946215 endingPage "S48" @default.
- W4212946215 startingPage "S45" @default.
- W4212946215 abstract "Nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most commonly used drugs to relieve a multitude of pain symptoms.F They are readily available and used extensively. There is a lot of concern about their adverse side effects namely cardiovascular (CV) and gastrointestinal (GI) side effects. It is important to have a good grasp of the pharmacology of these drugs in order to use them safely and effectively. NSAIDs work by inhibiting the cyclooxygenase (COX) enzyme system responsible for production of prostaglandins. Prostaglandins mediate pain inflammation and temperature regulation in the body. NSAIDS can be divided into selective and non-selective types. Three isoforms of COX have been identified COX-1, COX-2 and COX-3. Selective NSAIDs act on these isoforms. COX-1 is anti-inflammatory, COX-2 pro-inflammatory and COX-3, a variant of COX-1, does not produce prostaglandins. The CV side effects of these drugs can be wide ranging and include a rise in blood pressure (BP) and a higher risk of thromboembolic events. Patients also suffer from peptic ulcer disease or bleeding in the stomach as a result of their use. NSAIDs can cause liver and kidney toxicity and should be used with caution in patients with bleeding tendencies. New NSAIDs on the market include; lornoxicam (xefo®), meloxicam (coxflam®), celecoxib (celebrex®), parecoxib (rayzon®) and etoricoxib (arcoxia®). New ways of delivering NSAIDs to the body with minimal or no side effects are being researched. Novel technology in this field includes nano formulated NSAIDs; indomethacin (tivorbex®) and dicofenac (zorvolex), prodrugs and multi action drugs; cyclooxygenase inhibiting nitric oxide donors and hydrogen sulphide releasing drugs. Further exciting innovations are in the pipeline that could change the face of how we use these drugs. Until then they must be used with careful consideration and only if the benefits of use outweigh the risks." @default.
- W4212946215 created "2022-02-24" @default.
- W4212946215 creator A5054323180 @default.
- W4212946215 date "2020-11-19" @default.
- W4212946215 modified "2023-10-01" @default.
- W4212946215 title "Novel NSAIDs" @default.
- W4212946215 cites W1480874656 @default.
- W4212946215 cites W1956700960 @default.
- W4212946215 cites W2010356890 @default.
- W4212946215 cites W2103005476 @default.
- W4212946215 cites W2139492524 @default.
- W4212946215 cites W2144794987 @default.
- W4212946215 cites W2512252150 @default.
- W4212946215 cites W2981203653 @default.
- W4212946215 cites W3006790800 @default.
- W4212946215 cites W31280369 @default.
- W4212946215 cites W4234754714 @default.
- W4212946215 cites W4236940591 @default.
- W4212946215 doi "https://doi.org/10.36303/sajaa.2020.26.6.s3.2536" @default.
- W4212946215 hasPublicationYear "2020" @default.
- W4212946215 type Work @default.
- W4212946215 citedByCount "0" @default.
- W4212946215 crossrefType "journal-article" @default.
- W4212946215 hasAuthorship W4212946215A5054323180 @default.
- W4212946215 hasBestOaLocation W42129462151 @default.
- W4212946215 hasConcept C126322002 @default.
- W4212946215 hasConcept C181199279 @default.
- W4212946215 hasConcept C185592680 @default.
- W4212946215 hasConcept C197934379 @default.
- W4212946215 hasConcept C2776214540 @default.
- W4212946215 hasConcept C2776467144 @default.
- W4212946215 hasConcept C2776914184 @default.
- W4212946215 hasConcept C2777456732 @default.
- W4212946215 hasConcept C2778484676 @default.
- W4212946215 hasConcept C2778582115 @default.
- W4212946215 hasConcept C2779528491 @default.
- W4212946215 hasConcept C2779689624 @default.
- W4212946215 hasConcept C2779751750 @default.
- W4212946215 hasConcept C2780035454 @default.
- W4212946215 hasConcept C55493867 @default.
- W4212946215 hasConcept C71924100 @default.
- W4212946215 hasConcept C98274493 @default.
- W4212946215 hasConceptScore W4212946215C126322002 @default.
- W4212946215 hasConceptScore W4212946215C181199279 @default.
- W4212946215 hasConceptScore W4212946215C185592680 @default.
- W4212946215 hasConceptScore W4212946215C197934379 @default.
- W4212946215 hasConceptScore W4212946215C2776214540 @default.
- W4212946215 hasConceptScore W4212946215C2776467144 @default.
- W4212946215 hasConceptScore W4212946215C2776914184 @default.
- W4212946215 hasConceptScore W4212946215C2777456732 @default.
- W4212946215 hasConceptScore W4212946215C2778484676 @default.
- W4212946215 hasConceptScore W4212946215C2778582115 @default.
- W4212946215 hasConceptScore W4212946215C2779528491 @default.
- W4212946215 hasConceptScore W4212946215C2779689624 @default.
- W4212946215 hasConceptScore W4212946215C2779751750 @default.
- W4212946215 hasConceptScore W4212946215C2780035454 @default.
- W4212946215 hasConceptScore W4212946215C55493867 @default.
- W4212946215 hasConceptScore W4212946215C71924100 @default.
- W4212946215 hasConceptScore W4212946215C98274493 @default.
- W4212946215 hasLocation W42129462151 @default.
- W4212946215 hasOpenAccess W4212946215 @default.
- W4212946215 hasPrimaryLocation W42129462151 @default.
- W4212946215 hasRelatedWork W1562063526 @default.
- W4212946215 hasRelatedWork W158929790 @default.
- W4212946215 hasRelatedWork W1902187490 @default.
- W4212946215 hasRelatedWork W2023825382 @default.
- W4212946215 hasRelatedWork W2053833211 @default.
- W4212946215 hasRelatedWork W2055394727 @default.
- W4212946215 hasRelatedWork W2065685941 @default.
- W4212946215 hasRelatedWork W310847264 @default.
- W4212946215 hasRelatedWork W3203192493 @default.
- W4212946215 hasRelatedWork W4212946215 @default.
- W4212946215 isParatext "false" @default.
- W4212946215 isRetracted "false" @default.
- W4212946215 workType "article" @default.