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- W4212957688 startingPage "39" @default.
- W4212957688 abstract "Osteoarthritis (OA) is the most common joint disease. In the last years, the research community has focused on understanding the molecular mechanisms that led to the pathogenesis of the disease, trying to identify different molecular and clinical phenotypes along with the discovery of new therapeutic opportunities. Different types of cell-to-cell communication mechanisms have been proposed to contribute to OA progression, including mechanisms mediated by connexin43 (Cx43) channels or by small extracellular vesicles. Furthermore, changes in the chondrocyte phenotype such as cellular senescence have been proposed as new contributors of the OA progression, changing the paradigm of the disease. The use of different drugs able to restore chondrocyte phenotype, to reduce cellular senescence and senescence-associated secretory phenotype components, and to modulate ion channel activity or Cx43 appears to be promising therapeutic strategies for the different types of OA. In this review, we aim to summarize the current knowledge in OA phenotypes related with aging and tissue damage and the new therapeutic opportunities currently available." @default.
- W4212957688 created "2022-02-24" @default.
- W4212957688 creator A5002332932 @default.
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- W4212957688 creator A5067767226 @default.
- W4212957688 creator A5076320634 @default.
- W4212957688 creator A5089267270 @default.
- W4212957688 date "2022-03-01" @default.
- W4212957688 modified "2023-10-17" @default.
- W4212957688 title "Osteoarthritis: Mechanistic Insights, Senescence, and Novel Therapeutic Opportunities" @default.
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