Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212962740> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4212962740 abstract "Abstract Background: The current study was aimed to investigate the mechanisms of advanced glycation end products (AGEs) in exacerbating post- myocardial infarction (MI) ventricular arrhythmias (VAs). Methods: Correlation between premature ventricular contractions (PVCs) and serum AGEs concentrations was analyzed in a cohort consisted of 101 STEMI patients with culprit vessel of left anterior descending artery (LAD). Established MI rat model were treated with AGEs and/or anti- receptor for AGE (RAGE) antibody. Electrocardiography was used to record VAs. Myocytes were isolated from adjacent area around infracted region. Immunofluorescent stains were used to evaluate association between FKBP12.6 (FK506-bindingprotein 12.6) and ryanodine receptor 2 (RyR2). Calcium sparks were evaluated by confocal microscope. Protein expression and phosphorylation were assessed by Western blotting. A colorimetric method was used to determine the enzymatic activity of calcineurin (CaN). [ 3 H]-ryanodine binding assay was carried out to detect the RyR2 channel activity. Results: In the cohort study, significantly increased amount of (PVCs) were found in STEMI patients with diabetes (P<0.05). Serum AGEs concentration was significantly positively correlated with PVCs amount in STEMI patients (r=0.416, P<0.001). Multivariate analysis showed serum AGEs concentration was independently and positively related to frequent PVCs (adjusted hazard ratio, 1.86; 95% CI, 1.09-3.18, P=0.022). In the animal study, increased glucose regulated protein 78 (GRP78) expression, protein kinase RNA-like ER kinase (PERK) phosphorylation, CaN enzymatic activity, FKBP12.6-RyR2 disassociation, RyR2 channel opening and endoplasmic reticulum (ER) calcium releasing were found in MI animals exposed to AGEs, which were attenuated by anti-RAGE antibody treatment. This RAGE blocking also significantly lowered the VAs amount in MI animals exposed to AGEs. Conclusions: Hyper-activation of ER stress- mediated PERK/CaN/RyR2 signaling participated in AGEs- exacerbated post-MI VAs." @default.
- W4212962740 created "2022-02-24" @default.
- W4212962740 creator A5009777873 @default.
- W4212962740 creator A5017383224 @default.
- W4212962740 creator A5023450395 @default.
- W4212962740 creator A5028456676 @default.
- W4212962740 creator A5063380756 @default.
- W4212962740 creator A5082797513 @default.
- W4212962740 creator A5085856080 @default.
- W4212962740 date "2020-08-05" @default.
- W4212962740 modified "2023-09-28" @default.
- W4212962740 title "Hyper-Activation of Endoplasmic Reticulum Stress PERK/Calcineurin/RyR2 Signaling Pathway is Involved in AGEs-Exacerbated Post- Myocardial Infarction Ventricular Arrhythmias" @default.
- W4212962740 doi "https://doi.org/10.21203/rs.3.rs-47561/v1" @default.
- W4212962740 hasPublicationYear "2020" @default.
- W4212962740 type Work @default.
- W4212962740 citedByCount "0" @default.
- W4212962740 crossrefType "posted-content" @default.
- W4212962740 hasAuthorship W4212962740A5009777873 @default.
- W4212962740 hasAuthorship W4212962740A5017383224 @default.
- W4212962740 hasAuthorship W4212962740A5023450395 @default.
- W4212962740 hasAuthorship W4212962740A5028456676 @default.
- W4212962740 hasAuthorship W4212962740A5063380756 @default.
- W4212962740 hasAuthorship W4212962740A5082797513 @default.
- W4212962740 hasAuthorship W4212962740A5085856080 @default.
- W4212962740 hasBestOaLocation W42129627401 @default.
- W4212962740 hasConcept C113217602 @default.
- W4212962740 hasConcept C126322002 @default.
- W4212962740 hasConcept C128057223 @default.
- W4212962740 hasConcept C134018914 @default.
- W4212962740 hasConcept C158617107 @default.
- W4212962740 hasConcept C164705383 @default.
- W4212962740 hasConcept C185592680 @default.
- W4212962740 hasConcept C190712762 @default.
- W4212962740 hasConcept C2911091166 @default.
- W4212962740 hasConcept C500558357 @default.
- W4212962740 hasConcept C519063684 @default.
- W4212962740 hasConcept C55493867 @default.
- W4212962740 hasConcept C71924100 @default.
- W4212962740 hasConceptScore W4212962740C113217602 @default.
- W4212962740 hasConceptScore W4212962740C126322002 @default.
- W4212962740 hasConceptScore W4212962740C128057223 @default.
- W4212962740 hasConceptScore W4212962740C134018914 @default.
- W4212962740 hasConceptScore W4212962740C158617107 @default.
- W4212962740 hasConceptScore W4212962740C164705383 @default.
- W4212962740 hasConceptScore W4212962740C185592680 @default.
- W4212962740 hasConceptScore W4212962740C190712762 @default.
- W4212962740 hasConceptScore W4212962740C2911091166 @default.
- W4212962740 hasConceptScore W4212962740C500558357 @default.
- W4212962740 hasConceptScore W4212962740C519063684 @default.
- W4212962740 hasConceptScore W4212962740C55493867 @default.
- W4212962740 hasConceptScore W4212962740C71924100 @default.
- W4212962740 hasLocation W42129627401 @default.
- W4212962740 hasOpenAccess W4212962740 @default.
- W4212962740 hasPrimaryLocation W42129627401 @default.
- W4212962740 hasRelatedWork W1975700762 @default.
- W4212962740 hasRelatedWork W1986273190 @default.
- W4212962740 hasRelatedWork W2024858633 @default.
- W4212962740 hasRelatedWork W2043042191 @default.
- W4212962740 hasRelatedWork W2089232336 @default.
- W4212962740 hasRelatedWork W2287037998 @default.
- W4212962740 hasRelatedWork W2412710947 @default.
- W4212962740 hasRelatedWork W2434512304 @default.
- W4212962740 hasRelatedWork W2464779735 @default.
- W4212962740 hasRelatedWork W2474136078 @default.
- W4212962740 isParatext "false" @default.
- W4212962740 isRetracted "false" @default.
- W4212962740 workType "article" @default.