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- W4212963658 abstract "Glypican-3 (GPC3) is a membrane-associated proteoglycan that is specifically up-regulated in hepatocellular carcinoma (HCC) although rarely or not expressed in normal liver tissues, making it a perfect diagnostic and treatment target for HCC. Several GPC3-based clinical trials are ongoing and recently several innovative GPC3-targeted therapeutic methods have emerged with exciting results, including GPC3 vaccine, anti-GPC3 immunotoxin, combined therapy with immune checkpoint blockades (ICBs), and chimeric antigen receptor (CAR) T or NK cells. Here, we review the value of GPC3 in the diagnosis and prognosis of HCC, together with its signaling pathways, with a specific focus on GPC3-targeted treatments of HCC and some prospects for the future GPC3-based therapeutic strategies in HCC." @default.
- W4212963658 created "2022-02-24" @default.
- W4212963658 creator A5014806180 @default.
- W4212963658 creator A5030921116 @default.
- W4212963658 creator A5050737793 @default.
- W4212963658 creator A5060347257 @default.
- W4212963658 creator A5081943049 @default.
- W4212963658 date "2022-02-16" @default.
- W4212963658 modified "2023-10-05" @default.
- W4212963658 title "Glypican-3: A Novel and Promising Target for the Treatment of Hepatocellular Carcinoma" @default.
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