FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212969233> ?p ?o ?g. }

• W4212969233 endingPage "761" @default.
• W4212969233 startingPage "746" @default.
• W4212969233 abstract "Although PAD enzymes have high sequence homology, each enzyme isoform has its own features, including unique functions and specific tissue expression. PADs are expressed throughout the body but have a preference for structural proteins and nuclear substrates, such as histones. Therefore, the latest insights reveal how PAD activity affects cytoskeletal organization and gene expression. Evidence for extracellular citrullination is emerging in physiology and pathology. Recent insights in periodontitis show that exogenous proteins citrullinated by Porphyromonas gingivalis do not generate autoreactivity and dispute the role of P. gingivalis role in loss of tolerance. Aberrant citrullinated proteins disturb normal physiological processes in many inflammatory disorders and cancers outside rheumatoid arthritis or multiple sclerosis. Citrullinated histones in plasma are markers of bacterial and viral sepsis. Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate citrullination, an irreversible post-translational modification (PTM). PAD enzymes have received increasing attention in (patho-)physiology since multi-omics analysis accelerated their expression profiling. Here, we provide a comprehensive overview of PAD expression at the RNA and protein levels, and a list of annotated substrates per PAD isozyme. We discuss novel roles of citrullination in cellular growth, epigenetic regulation, tissue remodeling, inflammation, and cancer in mouse models and humans. Additionally, we cluster similar effects of protein deimination to offer a different perspective and improve our understanding of citrullination in health and disease. Citrullination should no longer be considered as a rare PTM, but as an important regulatory mechanism in physiology and pathology. Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate citrullination, an irreversible post-translational modification (PTM). PAD enzymes have received increasing attention in (patho-)physiology since multi-omics analysis accelerated their expression profiling. Here, we provide a comprehensive overview of PAD expression at the RNA and protein levels, and a list of annotated substrates per PAD isozyme. We discuss novel roles of citrullination in cellular growth, epigenetic regulation, tissue remodeling, inflammation, and cancer in mouse models and humans. Additionally, we cluster similar effects of protein deimination to offer a different perspective and improve our understanding of citrullination in health and disease. Citrullination should no longer be considered as a rare PTM, but as an important regulatory mechanism in physiology and pathology. uncontrolled citrullination when PADs are too active and modify too many arginine residues or citrullinate substrates that should remain unmodified. antibodies that recognize citrullinated proteins. ACPAs are typically generated during the autoimmune response observed in patients with RA. Therefore, ACPAs are currently used for the diagnosis of this disease. chemotactic cytokines that mediate the directional recruitment of immune cells through G-protein-coupled receptors. chemical inhibitor of PAD activity. reaction that converts a citrulline to an arginine amino acid. development of immune responses against epitopes that differ from the epitope that was recognized by T cell receptors or antibodies at the onset of a specific immune reaction. These new epitopes may be present on endogenous proteins instead of the disease-causing epitope and, therefore, sustain autoinflammation. in the cell cycle, cells grow in the G1 phase and transition to the S-phase, during which DNA is replicated. p53 controls this transition phase and interrupts cell cycles that contain damaged DNA. large molecules expressed by Gram-negative bacteria; comprise a lipid and a sugar chain and are considered endotoxins. foreign antigens that resemble self-antigens in their structure or sequence, making them more prone to break self-tolerance. form of cellular defence in which neutrophils expulse DNA to the extracellular environment to stimulate microbial clearance. complex of transcription factors that mediate the expression of proinflammatory genes, such as those encoding cytokines and chemokines. to distinguish between free amino acids and protein-bound amino acids, ‘peptidyl’ precedes the specific amino acid to indicate it is incorporated in a protein. single molecules or proteins that combine to form a complex with multiple entities. translated proteins can be modified chemically or enzymatically in a PTM that may change their biological function. propagation of action potentials along myelinated axons. genetic polymorphism that only affects a single nucleotide in the DNA sequence. blood-clotting process. class of receptors that are expressed by macrophages and dendritic cells that recognize microbial molecules, such as LPS." @default.
• W4212969233 created "2022-02-24" @default.
• W4212969233 creator A5003334601 @default.
• W4212969233 creator A5067567986 @default.
• W4212969233 date "2022-09-01" @default.
• W4212969233 modified "2023-10-02" @default.
• W4212969233 title "Insights into peptidylarginine deiminase expression and citrullination pathways" @default.
• W4212969233 cites W1799202546 @default.
• W4212969233 cites W1967211753 @default.
• W4212969233 cites W1971310354 @default.
• W4212969233 cites W1982650478 @default.
• W4212969233 cites W1986557532 @default.
• W4212969233 cites W1989763054 @default.
• W4212969233 cites W1990985385 @default.
• W4212969233 cites W1995950574 @default.
• W4212969233 cites W1998890104 @default.
• W4212969233 cites W2005699747 @default.
• W4212969233 cites W2009676595 @default.
• W4212969233 cites W2012034410 @default.
• W4212969233 cites W2012207611 @default.
• W4212969233 cites W2015822599 @default.
• W4212969233 cites W2020940640 @default.
• W4212969233 cites W2023238101 @default.
• W4212969233 cites W2029473544 @default.
• W4212969233 cites W2035601236 @default.
• W4212969233 cites W2043539405 @default.
• W4212969233 cites W2045433754 @default.
• W4212969233 cites W2048134537 @default.
• W4212969233 cites W2057896776 @default.
• W4212969233 cites W2059947650 @default.
• W4212969233 cites W2060275204 @default.
• W4212969233 cites W2069036796 @default.
• W4212969233 cites W2071184823 @default.
• W4212969233 cites W2071700927 @default.
• W4212969233 cites W2072164029 @default.
• W4212969233 cites W2078685341 @default.
• W4212969233 cites W2081340836 @default.
• W4212969233 cites W2083753771 @default.
• W4212969233 cites W2084234957 @default.
• W4212969233 cites W2086420062 @default.
• W4212969233 cites W2092905357 @default.
• W4212969233 cites W2097957649 @default.
• W4212969233 cites W2100637259 @default.
• W4212969233 cites W2104590417 @default.
• W4212969233 cites W2116909977 @default.
• W4212969233 cites W2125110523 @default.
• W4212969233 cites W2132891633 @default.
• W4212969233 cites W2135849676 @default.
• W4212969233 cites W2139610636 @default.
• W4212969233 cites W2154040419 @default.
• W4212969233 cites W2157558787 @default.
• W4212969233 cites W2162889000 @default.
• W4212969233 cites W2162968791 @default.
• W4212969233 cites W2167212772 @default.
• W4212969233 cites W2169489997 @default.
• W4212969233 cites W2170806891 @default.
• W4212969233 cites W2172339454 @default.
• W4212969233 cites W2188147812 @default.
• W4212969233 cites W2342532453 @default.
• W4212969233 cites W2345389081 @default.
• W4212969233 cites W2512801459 @default.
• W4212969233 cites W2546931104 @default.
• W4212969233 cites W2562661149 @default.
• W4212969233 cites W2562800512 @default.
• W4212969233 cites W2570455648 @default.
• W4212969233 cites W2604995125 @default.
• W4212969233 cites W2609995827 @default.
• W4212969233 cites W2611153150 @default.
• W4212969233 cites W2621491385 @default.
• W4212969233 cites W2745290353 @default.
• W4212969233 cites W2759451658 @default.
• W4212969233 cites W2766157021 @default.
• W4212969233 cites W2773563175 @default.
• W4212969233 cites W2783165679 @default.
• W4212969233 cites W2796138116 @default.
• W4212969233 cites W2877716630 @default.
• W4212969233 cites W2899743407 @default.
• W4212969233 cites W2902821453 @default.
• W4212969233 cites W2910899726 @default.
• W4212969233 cites W2911630412 @default.
• W4212969233 cites W2924399727 @default.
• W4212969233 cites W2925522833 @default.
• W4212969233 cites W2941937589 @default.
• W4212969233 cites W2950674650 @default.
• W4212969233 cites W2952049537 @default.
• W4212969233 cites W2953781498 @default.
• W4212969233 cites W2954636025 @default.
• W4212969233 cites W2954860678 @default.
• W4212969233 cites W2967469077 @default.
• W4212969233 cites W2971230652 @default.
• W4212969233 cites W2979374144 @default.
• W4212969233 cites W2987754376 @default.
• W4212969233 cites W2991173063 @default.
• W4212969233 cites W2994353602 @default.
• W4212969233 cites W2996045117 @default.
• W4212969233 cites W2999151985 @default.
• W4212969233 cites W3000238803 @default.
• W4212969233 cites W3007377348 @default.

• next