FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212972525> ?p ?o ?g. }

• W4212972525 abstract "<sec> <title>BACKGROUND</title> Most of colorectal cancer diagnosed are candidates for surgical resection with curative intent, although colorectal surgery is associated with some complications that could be life-threatening. Antibiotic prophylaxis is commonly used for the prevention of infectious postoperative complications. However, this intervention can change the composition of intestinal microbiota and promote adverse inflammatory outcomes in colorectal cancer patients. It seems that the combination of different fungal extracts could be beneficial because of their role in gut microbiota modulation and their anti-inflammatory activity. </sec> <sec> <title>OBJECTIVE</title> Based on this hypothesis, we have designed a double-bind randomized clinical trial to evaluate the effect of the nutraceutical fungal extract MICODIGEST 2.0 on the complications of surgery for colorectal cancer resection. </sec> <sec> <title>METHODS</title> Colorectal cancer candidates for surgery will be considered for inclusion in the study. After evaluation in the multidisciplinary tumor board, patients who fulfill criteria will be screened, stratified according to the tumor location and randomly allocated to be treated with MICODIGEST 2.0 or placebo. Treatment will be continued until admission for surgery (4-6 weeks). Participants will also undergo a medical and clinical evaluation, which will include baseline and before admission quality of life, microbiome composition, inflammatory and nutritional status, adverse events and adherence. The main endpoint of the study is the surgery complication rate. We will evaluate them using the Clavien-Dindo classification. It would be necessary to recruit a total of 144 patients to find a relevant clinical difference. We will also evaluate the effect of the nutraceutical on microbiome composition, inflammatory response, nutritional status and quality of life, as well as the effect of these variables on the surgical complications. </sec> <sec> <title>RESULTS</title> This study was funded in 2020 by the Center for Industrial Technology Development. The recruitment started in September 2021 and is expected to be completed in September 2022. Data will be analyzed and the results will be disseminated in 2023. </sec> <sec> <title>CONCLUSIONS</title> The results of this protocol study could help to reduce the surgery complications in patients with colorectal cancer using the new treatment MICODIGEST. Apart from this treatment, this study could also identify new features associated with colorectal surgery complications. In summary, this study trial could improve the management of colorectal cancer patients. </sec> <sec> <title>CLINICALTRIAL</title> Clinical Trials.gov. Identifier: NCT04821258. Registered on March 29, 2021. </sec>" @default.
• W4212972525 created "2022-02-24" @default.
• W4212972525 creator A5004084289 @default.
• W4212972525 creator A5018692814 @default.
• W4212972525 creator A5027107202 @default.
• W4212972525 creator A5029647337 @default.
• W4212972525 creator A5031514693 @default.
• W4212972525 creator A5057721876 @default.
• W4212972525 creator A5060761296 @default.
• W4212972525 creator A5060930528 @default.
• W4212972525 creator A5070310188 @default.
• W4212972525 date "2021-10-15" @default.
• W4212972525 modified "2023-09-25" @default.
• W4212972525 title "The Effect of the Nutraceutical MICODIGEST 2.0 on the Colorectal Cancer Surgery With Curative Intent Complications Rate: A Study Protocol for a Placebo-Controlled Double-blind Randomized Clinical Trial (Preprint)" @default.
• W4212972525 cites W1919048856 @default.
• W4212972525 cites W1969635665 @default.
• W4212972525 cites W1979979625 @default.
• W4212972525 cites W2007815328 @default.
• W4212972525 cites W2058777326 @default.
• W4212972525 cites W2059188233 @default.
• W4212972525 cites W2064906725 @default.
• W4212972525 cites W2144173184 @default.
• W4212972525 cites W2149515881 @default.
• W4212972525 cites W2158764247 @default.
• W4212972525 cites W2166679616 @default.
• W4212972525 cites W2171811563 @default.
• W4212972525 cites W2332909709 @default.
• W4212972525 cites W2585481397 @default.
• W4212972525 cites W2592679671 @default.
• W4212972525 cites W2599405616 @default.
• W4212972525 cites W2607971839 @default.
• W4212972525 cites W2624433117 @default.
• W4212972525 cites W2726639669 @default.
• W4212972525 cites W2794286144 @default.
• W4212972525 cites W2887352686 @default.
• W4212972525 cites W2895331457 @default.
• W4212972525 cites W2915149968 @default.
• W4212972525 cites W2916751520 @default.
• W4212972525 cites W2918821123 @default.
• W4212972525 cites W2970537129 @default.
• W4212972525 cites W3017073206 @default.
• W4212972525 cites W3039704653 @default.
• W4212972525 cites W3080354041 @default.
• W4212972525 cites W3083588152 @default.
• W4212972525 cites W4246883504 @default.
• W4212972525 doi "https://doi.org/10.2196/preprints.34292" @default.
• W4212972525 hasPublicationYear "2021" @default.
• W4212972525 type Work @default.
• W4212972525 citedByCount "0" @default.
• W4212972525 crossrefType "posted-content" @default.
• W4212972525 hasAuthorship W4212972525A5004084289 @default.
• W4212972525 hasAuthorship W4212972525A5018692814 @default.
• W4212972525 hasAuthorship W4212972525A5027107202 @default.
• W4212972525 hasAuthorship W4212972525A5029647337 @default.
• W4212972525 hasAuthorship W4212972525A5031514693 @default.
• W4212972525 hasAuthorship W4212972525A5057721876 @default.
• W4212972525 hasAuthorship W4212972525A5060761296 @default.
• W4212972525 hasAuthorship W4212972525A5060930528 @default.
• W4212972525 hasAuthorship W4212972525A5070310188 @default.
• W4212972525 hasBestOaLocation W42129725252 @default.
• W4212972525 hasConcept C121608353 @default.
• W4212972525 hasConcept C126322002 @default.
• W4212972525 hasConcept C141071460 @default.
• W4212972525 hasConcept C142724271 @default.
• W4212972525 hasConcept C159110408 @default.
• W4212972525 hasConcept C168563851 @default.
• W4212972525 hasConcept C197934379 @default.
• W4212972525 hasConcept C203092338 @default.
• W4212972525 hasConcept C204787440 @default.
• W4212972525 hasConcept C27081682 @default.
• W4212972525 hasConcept C2779951463 @default.
• W4212972525 hasConcept C2780120127 @default.
• W4212972525 hasConcept C523026621 @default.
• W4212972525 hasConcept C526805850 @default.
• W4212972525 hasConcept C535046627 @default.
• W4212972525 hasConcept C71924100 @default.
• W4212972525 hasConceptScore W4212972525C121608353 @default.
• W4212972525 hasConceptScore W4212972525C126322002 @default.
• W4212972525 hasConceptScore W4212972525C141071460 @default.
• W4212972525 hasConceptScore W4212972525C142724271 @default.
• W4212972525 hasConceptScore W4212972525C159110408 @default.
• W4212972525 hasConceptScore W4212972525C168563851 @default.
• W4212972525 hasConceptScore W4212972525C197934379 @default.
• W4212972525 hasConceptScore W4212972525C203092338 @default.
• W4212972525 hasConceptScore W4212972525C204787440 @default.
• W4212972525 hasConceptScore W4212972525C27081682 @default.
• W4212972525 hasConceptScore W4212972525C2779951463 @default.
• W4212972525 hasConceptScore W4212972525C2780120127 @default.
• W4212972525 hasConceptScore W4212972525C523026621 @default.
• W4212972525 hasConceptScore W4212972525C526805850 @default.
• W4212972525 hasConceptScore W4212972525C535046627 @default.
• W4212972525 hasConceptScore W4212972525C71924100 @default.
• W4212972525 hasLocation W42129725251 @default.
• W4212972525 hasLocation W42129725252 @default.
• W4212972525 hasOpenAccess W4212972525 @default.
• W4212972525 hasPrimaryLocation W42129725251 @default.
• W4212972525 hasRelatedWork W2036346027 @default.
• W4212972525 hasRelatedWork W2085830368 @default.
• W4212972525 hasRelatedWork W2766008196 @default.
• W4212972525 hasRelatedWork W3007053288 @default.

• next