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• W4212981270 startingPage "2397" @default.
• W4212981270 abstract "Diabetes mellitus is a comprehensive expression to identify a condition of chronic hyperglycemia whose causes derive from different metabolic disorders characterized by altered insulin secretion or faulty insulin effect on its targets or often both mechanisms. Diabetes and atherosclerosis are, from the point of view of cardio- and cerebrovascular risk, two complementary diseases. Beyond shared aspects such as inflammation and oxidative stress, there are multiple molecular mechanisms by which they feed off each other: chronic hyperglycemia and advanced glycosylation end-products (AGE) promote 'accelerated atherosclerosis' through the induction of endothelial damage and cellular dysfunction. These diseases impact the vascular system and, therefore, the risk of developing cardio- and cerebrovascular events is now evident, but the observation of this significant correlation has its roots in past decades. Cerebrovascular complications make diabetic patients 2-6 times more susceptible to a stroke event and this risk is magnified in younger individuals and in patients with hypertension and complications in other vascular beds. In addition, when patients with diabetes and hyperglycemia experience an acute ischemic stroke, they are more likely to die or be severely disabled and less likely to benefit from the one FDA-approved therapy, intravenous tissue plasminogen activator. Experimental stroke models have revealed that chronic hyperglycemia leads to deficits in cerebrovascular structure and function that may explain some of the clinical observations. Increased edema, neovascularization, and protease expression as well as altered vascular reactivity and tone may be involved and point to potential therapeutic targets. Further study is needed to fully understand this complex disease state and the breadth of its manifestation in the cerebrovasculature." @default.
• W4212981270 created "2022-02-24" @default.
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• W4212981270 date "2022-02-21" @default.
• W4212981270 modified "2023-10-13" @default.
• W4212981270 title "Diabetes and Ischemic Stroke: An Old and New Relationship an Overview of the Close Interaction between These Diseases" @default.
• W4212981270 cites W11598776 @default.
• W4212981270 cites W1512022716 @default.
• W4212981270 cites W1514838725 @default.
• W4212981270 cites W1520348292 @default.
• W4212981270 cites W1545732697 @default.
• W4212981270 cites W1551533003 @default.
• W4212981270 cites W1592471891 @default.
• W4212981270 cites W1650965741 @default.
• W4212981270 cites W1814020593 @default.
• W4212981270 cites W1875822983 @default.
• W4212981270 cites W1877637989 @default.
• W4212981270 cites W1963607067 @default.
• W4212981270 cites W1963885665 @default.
• W4212981270 cites W1966907372 @default.
• W4212981270 cites W1968727310 @default.
• W4212981270 cites W1969322919 @default.
• W4212981270 cites W1971680839 @default.
• W4212981270 cites W1974455513 @default.
• W4212981270 cites W1975114478 @default.
• W4212981270 cites W1975254770 @default.
• W4212981270 cites W1976161722 @default.
• W4212981270 cites W1976422365 @default.
• W4212981270 cites W1977807698 @default.
• W4212981270 cites W1978844801 @default.
• W4212981270 cites W1980054560 @default.
• W4212981270 cites W1980978339 @default.
• W4212981270 cites W1986001078 @default.
• W4212981270 cites W1987415392 @default.
• W4212981270 cites W1990394848 @default.
• W4212981270 cites W1992152105 @default.
• W4212981270 cites W1994355980 @default.
• W4212981270 cites W1995237865 @default.
• W4212981270 cites W1995388442 @default.
• W4212981270 cites W1996088329 @default.
• W4212981270 cites W1996839970 @default.
• W4212981270 cites W1997083960 @default.
• W4212981270 cites W1998441050 @default.
• W4212981270 cites W1998666012 @default.
• W4212981270 cites W2002910927 @default.
• W4212981270 cites W2007728294 @default.
• W4212981270 cites W2007880055 @default.
• W4212981270 cites W2007915713 @default.
• W4212981270 cites W2008309611 @default.
• W4212981270 cites W2009410829 @default.
• W4212981270 cites W2010011292 @default.
• W4212981270 cites W2011192430 @default.
• W4212981270 cites W2013637636 @default.
• W4212981270 cites W2014179250 @default.
• W4212981270 cites W2014572524 @default.
• W4212981270 cites W2014759828 @default.
• W4212981270 cites W2017333134 @default.
• W4212981270 cites W2018316042 @default.
• W4212981270 cites W2019020805 @default.
• W4212981270 cites W2019806913 @default.
• W4212981270 cites W2021025717 @default.
• W4212981270 cites W2021343620 @default.
• W4212981270 cites W2023521562 @default.
• W4212981270 cites W2023590207 @default.
• W4212981270 cites W202448326 @default.
• W4212981270 cites W2027218341 @default.
• W4212981270 cites W2029491963 @default.
• W4212981270 cites W2033365290 @default.
• W4212981270 cites W2033891772 @default.
• W4212981270 cites W2035678221 @default.
• W4212981270 cites W2039692317 @default.
• W4212981270 cites W2048488935 @default.
• W4212981270 cites W2049501468 @default.
• W4212981270 cites W2050070442 @default.
• W4212981270 cites W2051455962 @default.
• W4212981270 cites W2056460928 @default.
• W4212981270 cites W2058365382 @default.
• W4212981270 cites W2061062088 @default.
• W4212981270 cites W2062548334 @default.
• W4212981270 cites W2064285465 @default.
• W4212981270 cites W2065131308 @default.
• W4212981270 cites W2066963386 @default.
• W4212981270 cites W2068250128 @default.
• W4212981270 cites W2070692648 @default.
• W4212981270 cites W2072515252 @default.
• W4212981270 cites W2076534816 @default.
• W4212981270 cites W2077941478 @default.
• W4212981270 cites W2079724669 @default.
• W4212981270 cites W2080897456 @default.
• W4212981270 cites W2081526000 @default.
• W4212981270 cites W2084022910 @default.
• W4212981270 cites W2090964531 @default.
• W4212981270 cites W2091134449 @default.

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