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- W4212995246 abstract "Pancreatic ductal adenocarcinoma (PDAC) is an increasingly common cancer with a persistently poor prognosis, and only approximately 20% of patients are clearly anatomically resectable at diagnosis. Historically, a paucity of effective therapy made it inappropriate to forego the traditional gold standard of upfront surgery in favour of neoadjuvant treatment; however, modern combination chemotherapy regimens have made neoadjuvant therapy increasingly viable. As its use has expanded, the rationale for neoadjuvant therapy has evolved from one of 'downstaging' to one of early treatment of micro-metastases and selection of patients with favourable tumour biology for resection. Defining resectability in PDAC is problematic; multiple differing definitions exist. Multidisciplinary input, both in initial assessment of resectability and in supervision of multimodality therapy, is therefore advised. European and North American guidelines recommend the use of neoadjuvant chemotherapy in borderline resectable (BR)-PDAC. Similar regimens may be applied in locally advanced (LA)-PDAC with the aim of improving potential access to curative-intent resection, but appropriate patient selection is key due to significant rates of recurrence after excision of LA disease. Upfront surgery and adjuvant chemotherapy remain standard-of-care in clearly resectable PDAC, but multiple trials evaluating the use of neoadjuvant therapy in this and other localised settings are ongoing." @default.
- W4212995246 created "2022-02-24" @default.
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- W4212995246 date "2022-06-01" @default.
- W4212995246 modified "2023-10-13" @default.
- W4212995246 title "Clinical challenges associated with utility of neoadjuvant treatment in patients with pancreatic ductal adenocarcinoma" @default.
- W4212995246 cites W1606503260 @default.
- W4212995246 cites W1970383271 @default.
- W4212995246 cites W1974219858 @default.
- W4212995246 cites W1976414440 @default.
- W4212995246 cites W1985940725 @default.
- W4212995246 cites W1992458280 @default.
- W4212995246 cites W2008014332 @default.
- W4212995246 cites W2012005360 @default.
- W4212995246 cites W2017955572 @default.
- W4212995246 cites W2024477013 @default.
- W4212995246 cites W2031584923 @default.
- W4212995246 cites W2041820616 @default.
- W4212995246 cites W2042280230 @default.
- W4212995246 cites W2047318784 @default.
- W4212995246 cites W2050575833 @default.
- W4212995246 cites W2050643752 @default.
- W4212995246 cites W2066097107 @default.
- W4212995246 cites W2073768319 @default.
- W4212995246 cites W2092083235 @default.
- W4212995246 cites W2093115033 @default.
- W4212995246 cites W2101345979 @default.
- W4212995246 cites W2101653483 @default.
- W4212995246 cites W2117954462 @default.
- W4212995246 cites W2130409622 @default.
- W4212995246 cites W2138582833 @default.
- W4212995246 cites W2146621833 @default.
- W4212995246 cites W2150550712 @default.
- W4212995246 cites W2150881991 @default.
- W4212995246 cites W2151253787 @default.
- W4212995246 cites W2156057121 @default.
- W4212995246 cites W2157590016 @default.
- W4212995246 cites W2157826180 @default.
- W4212995246 cites W2165480504 @default.
- W4212995246 cites W2169060943 @default.
- W4212995246 cites W2398503175 @default.
- W4212995246 cites W2412717755 @default.
- W4212995246 cites W2475004924 @default.
- W4212995246 cites W2531210961 @default.
- W4212995246 cites W2557297120 @default.
- W4212995246 cites W2561226755 @default.
- W4212995246 cites W2581973599 @default.
- W4212995246 cites W2601014096 @default.
- W4212995246 cites W2622499649 @default.
- W4212995246 cites W2738012214 @default.
- W4212995246 cites W2741230393 @default.
- W4212995246 cites W2743061229 @default.
- W4212995246 cites W2746266812 @default.
- W4212995246 cites W2762551988 @default.
- W4212995246 cites W2772770935 @default.
- W4212995246 cites W2790060488 @default.
- W4212995246 cites W2790356839 @default.
- W4212995246 cites W2800183215 @default.
- W4212995246 cites W2883498537 @default.
- W4212995246 cites W2886624030 @default.
- W4212995246 cites W2900266626 @default.
- W4212995246 cites W2903623792 @default.
- W4212995246 cites W2912196744 @default.
- W4212995246 cites W2915944698 @default.
- W4212995246 cites W2916751916 @default.
- W4212995246 cites W2921093881 @default.
- W4212995246 cites W2935521909 @default.
- W4212995246 cites W2946040614 @default.
- W4212995246 cites W2953173394 @default.
- W4212995246 cites W2969945405 @default.
- W4212995246 cites W2982461141 @default.
- W4212995246 cites W2993622087 @default.
- W4212995246 cites W3008190574 @default.
- W4212995246 cites W3010476760 @default.
- W4212995246 cites W3012839541 @default.
- W4212995246 cites W3019894803 @default.
- W4212995246 cites W3031901305 @default.
- W4212995246 cites W3082217539 @default.
- W4212995246 cites W3083989780 @default.
- W4212995246 cites W3110073091 @default.
- W4212995246 cites W3112148397 @default.
- W4212995246 cites W3153075376 @default.
- W4212995246 cites W3158338416 @default.
- W4212995246 cites W3169253960 @default.
- W4212995246 cites W3183427139 @default.
- W4212995246 cites W3198526185 @default.
- W4212995246 cites W4211253487 @default.
- W4212995246 cites W4226238781 @default.
- W4212995246 doi "https://doi.org/10.1016/j.ejso.2022.02.014" @default.
- W4212995246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35264307" @default.
- W4212995246 hasPublicationYear "2022" @default.
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