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• W4212999072 abstract "Experimental and theoretical 13C kinetic isotope effects (KIEs) are utilized to obtain atomistic insight into the catalytic mechanism of the Pd(PPh3)4-catalyzed Suzuki-Miyaura reaction of aryl halides and aryl boronic acids. Under catalytic conditions, we establish that oxidative addition of aryl bromides occurs to a 12-electron monoligated palladium complex (Pd-(PPh3)). This is based on the congruence of the experimental KIE for the carbon attached to bromine (KIEC-Br = 1.020) and predicted KIEC-Br for the transition state for oxidative addition to the Pd(PPh3) complex (1.021). For aryl iodides, the near-unity KIEC-I of ~1.003 suggests that the first irreversible step in the catalytic cycle precedes oxidative addition and is likely the binding of the iodoarene to Pd(PPh3). Our results suggest that the commonly proposed oxidative addition to the 14-electron Pd(PPh3)2 complex can occur only in the presence of excess added ligand or under stoichiometric conditions; in both cases, experimental KIEC-Br of 1.031 is measured, which is identical to the predicted KIEC-Br for the transition state for oxidative addition to the Pd(PPh3)2 complex (1.031). The transmetalation step, under catalytic conditions, is shown to proceed via a tetracoordinate boronate (8B4) intermediate with a Pd-O-B linkage based on the agreement between an experimental KIE for the carbon atom involved in transmetalation (KIEC-Boron = 1.035) and a predicted KIEC-Boron for the 8B4 transmetalation transition state (1.034)." @default.
• W4212999072 created "2022-02-24" @default.
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• W4212999072 date "2022-02-17" @default.
• W4212999072 modified "2023-10-05" @default.
• W4212999072 title "Isotope Effects Reveal the Catalytic Mechanism of the Archetypical Suzuki-Miyaura Reaction" @default.
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• W4212999072 doi "https://doi.org/10.1021/acscatal.1c05802" @default.
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• W4212999072 hasPublicationYear "2022" @default.
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