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- W4212999363 abstract "SUMMARY Influx of eosinophils into the lungs is typically associated with type-II responses during allergy, fungal and parasitic infections. However, we previously reported that eosinophils accumulate in lung lesions during type-I inflammatory responses to Mycobacterium tuberculosis (Mtb) in humans, macaques, and mice where they contribute to host resistance. Here we show eosinophils migrate into the lungs of macaques and mice as early as one week after Mtb-exposure. In mice this influx was CCR3 independent and instead required cell-intrinsic expression of the oxysterol-receptor GPR183, which is highly expressed on human and macaque eosinophils. Murine eosinophils interacted directly with bacilli-laden alveolar macrophages, which upregulated the oxysterol-synthesizing enzyme Ch25h, and eosinophil recruitment was impaired in Ch25h deficient mice. Our findings show that eosinophils are among the first cells from circulation to sense and respond to Mtb infection of alveolar macrophages and reveal a novel role for GPR183 in the migration of eosinophils into lung tissue. HIGHLIGHTS In mice and macaques eosinophils accumulate early in Mtb-infected lungs preceding neutrophils Eosinophils interact with Mtb-infected cells in the alveoli in mice Early pulmonary eosinophil migration occurs independently of CCR3 in mice Early lung migration in mice requires Ch25h and eosinophil-intrinsic GPR183 expression" @default.
- W4212999363 created "2022-02-24" @default.
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- W4212999363 date "2022-02-18" @default.
- W4212999363 modified "2023-09-22" @default.
- W4212999363 title "Rapid GPR183-mediated recruitment of eosinophils to the lung after <i>Mycobacterium tuberculosis</i> infection" @default.
- W4212999363 cites W1862564406 @default.
- W4212999363 cites W1963635975 @default.
- W4212999363 cites W1970058349 @default.
- W4212999363 cites W1972407010 @default.
- W4212999363 cites W1976186851 @default.
- W4212999363 cites W1993261989 @default.
- W4212999363 cites W1998477311 @default.
- W4212999363 cites W2010819095 @default.
- W4212999363 cites W2012397588 @default.
- W4212999363 cites W2016952830 @default.
- W4212999363 cites W2032634575 @default.
- W4212999363 cites W2033946555 @default.
- W4212999363 cites W2037123168 @default.
- W4212999363 cites W2039710848 @default.
- W4212999363 cites W2056521763 @default.
- W4212999363 cites W2059120529 @default.
- W4212999363 cites W2069286887 @default.
- W4212999363 cites W2071074768 @default.
- W4212999363 cites W2072517432 @default.
- W4212999363 cites W2081325862 @default.
- W4212999363 cites W2093418362 @default.
- W4212999363 cites W2102467166 @default.
- W4212999363 cites W2102806888 @default.
- W4212999363 cites W2126304335 @default.
- W4212999363 cites W2136561766 @default.
- W4212999363 cites W2162283579 @default.
- W4212999363 cites W2164309428 @default.
- W4212999363 cites W2285764698 @default.
- W4212999363 cites W2310773425 @default.
- W4212999363 cites W2323128871 @default.
- W4212999363 cites W2326410252 @default.
- W4212999363 cites W2346100156 @default.
- W4212999363 cites W2506032343 @default.
- W4212999363 cites W2583259744 @default.
- W4212999363 cites W2612351849 @default.
- W4212999363 cites W2614705174 @default.
- W4212999363 cites W2617908985 @default.
- W4212999363 cites W2755765772 @default.
- W4212999363 cites W2792317005 @default.
- W4212999363 cites W2799521111 @default.
- W4212999363 cites W2887886950 @default.
- W4212999363 cites W2888406753 @default.
- W4212999363 cites W2902886666 @default.
- W4212999363 cites W2938499334 @default.
- W4212999363 cites W2942768502 @default.
- W4212999363 cites W2948993041 @default.
- W4212999363 cites W2952253916 @default.
- W4212999363 cites W2964440191 @default.
- W4212999363 cites W2966718046 @default.
- W4212999363 cites W2991432231 @default.
- W4212999363 cites W3001445168 @default.
- W4212999363 cites W3007938882 @default.
- W4212999363 cites W3010372469 @default.
- W4212999363 cites W3011804351 @default.
- W4212999363 cites W3015425237 @default.
- W4212999363 cites W3022355441 @default.
- W4212999363 cites W3028997801 @default.
- W4212999363 cites W3034597699 @default.
- W4212999363 cites W3043642888 @default.
- W4212999363 cites W3097643358 @default.
- W4212999363 cites W3123360528 @default.
- W4212999363 cites W3129882595 @default.
- W4212999363 cites W3137895553 @default.
- W4212999363 cites W3188358226 @default.