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- W4213004577 abstract "The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity. In studies that explain how such cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate responsiveness. These findings permitted the identification of a previously unknown innate-like T cell subset and indicate that T cell hyporesponsiveness, a state traditionally linked to tolerance, may be fundamental to T cells entering the innate compartment and thereby providing lymphoid stress surveillance. PMID: 24241693 Funding information This work was supported by: Cancer Research UK, United Kingdom Wellcome Trust, United Kingdom" @default.
- W4213004577 created "2022-02-24" @default.
- W4213004577 creator A5002152110 @default.
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- W4213004577 date "2013-12-30" @default.
- W4213004577 modified "2023-09-27" @default.
- W4213004577 title "Faculty Opinions recommendation of Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness." @default.
- W4213004577 doi "https://doi.org/10.3410/f.718178521.793488645" @default.
- W4213004577 hasPublicationYear "2013" @default.
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