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- W4213005801 endingPage "577832" @default.
- W4213005801 startingPage "577832" @default.
- W4213005801 abstract "We previously reported that the single peripheral administration of lipopolysaccharide (LPS) induced robust and transient microglial proliferation or increased the microglial population in the circumventricular organs (CVOs) and other regions, including the hypothalamus, medulla oblongata, and limbic system. However, the functional significance of an increased microglial population during endotoxin-induced inflammation remains unclear. The present study showed microglial proliferation in the mouse brain during inflammation induced by 50 mg/kg zymosan, 160 nmol/kg prostaglandin E2, and 5 mg/kg LPS. The inhibition of LPS-induced microglial proliferation with a continuous i.c.v. infusion of mitotic inhibitor cytosine arabinoside (AraC) caused persistent decreases in body weight and food and water intakes. The continuous infusion of AraC also prolonged LPS-induced sickness responses, such as lower locomotor activity and core body temperature. Collectively, the present results indicate that a transient increase in the microglial population is beneficial during endotoxin-induced inflammation in the mouse brain because it attenuates sickness responses." @default.
- W4213005801 created "2022-02-24" @default.
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- W4213005801 creator A5036866620 @default.
- W4213005801 creator A5057854240 @default.
- W4213005801 creator A5080446092 @default.
- W4213005801 date "2022-04-01" @default.
- W4213005801 modified "2023-10-17" @default.
- W4213005801 title "Microglial proliferation attenuates sickness responses in adult mice during endotoxin-induced inflammation" @default.
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- W4213005801 doi "https://doi.org/10.1016/j.jneuroim.2022.577832" @default.
- W4213005801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35192968" @default.
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