Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213026610> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4213026610 abstract "Local T cell responses are required for optimal protection of the lungs against airborne pathogens. This localized protection is mediated by various immune cells, including resident memory T cells (TRM). While human lung CD8+ TRM line the epithelium and are enriched for recognition of respiratory viruses, we found CD4+ TRM to exhibit more heterogeneous localization patterns, surrounding airways, forming clusters in the lung parenchyma, and lining the epithelium. This heterogeneity was also reflected functionally, as lung CD4+ TRM were enriched for recognition of diverse classes of respiratory pathogens. Upon stimulation, lung CD4+ TRM expressed different polyfunctional cytokine profiles depending on the pathogen recognized. CD4+ TRM responding to respiratory viruses and bacteria were biased for production of IFN-γ and IL-17, respectively. Strikingly, pathogen-specific CD4+ TRM also represent a significant fraction in NSCLC tumors that remained polyfunctional despite high PD-1 expression. These findings are not only important for vaccine design, but also provide a rationale for reinvigorating anti-tumor immunity through triggering of polyfunctional pathogen-specific CD4+ tumor infiltrating lymphocytes." @default.
- W4213026610 created "2022-02-24" @default.
- W4213026610 creator A5009454909 @default.
- W4213026610 creator A5019478008 @default.
- W4213026610 creator A5027794634 @default.
- W4213026610 creator A5033008855 @default.
- W4213026610 creator A5046414309 @default.
- W4213026610 creator A5048993433 @default.
- W4213026610 creator A5062253998 @default.
- W4213026610 creator A5085800775 @default.
- W4213026610 creator A5090205644 @default.
- W4213026610 date "2022-02-19" @default.
- W4213026610 modified "2023-10-17" @default.
- W4213026610 title "Polyfunctional pathogen-specific CD4+ T cells reside in the lungs and tumors of NSCLC patients" @default.
- W4213026610 doi "https://doi.org/10.1101/2022.02.16.479923" @default.
- W4213026610 hasPublicationYear "2022" @default.
- W4213026610 type Work @default.
- W4213026610 citedByCount "1" @default.
- W4213026610 countsByYear W42130266102022 @default.
- W4213026610 crossrefType "posted-content" @default.
- W4213026610 hasAuthorship W4213026610A5009454909 @default.
- W4213026610 hasAuthorship W4213026610A5019478008 @default.
- W4213026610 hasAuthorship W4213026610A5027794634 @default.
- W4213026610 hasAuthorship W4213026610A5033008855 @default.
- W4213026610 hasAuthorship W4213026610A5046414309 @default.
- W4213026610 hasAuthorship W4213026610A5048993433 @default.
- W4213026610 hasAuthorship W4213026610A5062253998 @default.
- W4213026610 hasAuthorship W4213026610A5085800775 @default.
- W4213026610 hasAuthorship W4213026610A5090205644 @default.
- W4213026610 hasBestOaLocation W42130266101 @default.
- W4213026610 hasConcept C105702510 @default.
- W4213026610 hasConcept C126322002 @default.
- W4213026610 hasConcept C159047783 @default.
- W4213026610 hasConcept C167672396 @default.
- W4213026610 hasConcept C196822366 @default.
- W4213026610 hasConcept C203014093 @default.
- W4213026610 hasConcept C2776460866 @default.
- W4213026610 hasConcept C2777714996 @default.
- W4213026610 hasConcept C2778690821 @default.
- W4213026610 hasConcept C2779341262 @default.
- W4213026610 hasConcept C502942594 @default.
- W4213026610 hasConcept C529295009 @default.
- W4213026610 hasConcept C534529494 @default.
- W4213026610 hasConcept C54355233 @default.
- W4213026610 hasConcept C59822182 @default.
- W4213026610 hasConcept C71924100 @default.
- W4213026610 hasConcept C86803240 @default.
- W4213026610 hasConcept C87568996 @default.
- W4213026610 hasConcept C8891405 @default.
- W4213026610 hasConceptScore W4213026610C105702510 @default.
- W4213026610 hasConceptScore W4213026610C126322002 @default.
- W4213026610 hasConceptScore W4213026610C159047783 @default.
- W4213026610 hasConceptScore W4213026610C167672396 @default.
- W4213026610 hasConceptScore W4213026610C196822366 @default.
- W4213026610 hasConceptScore W4213026610C203014093 @default.
- W4213026610 hasConceptScore W4213026610C2776460866 @default.
- W4213026610 hasConceptScore W4213026610C2777714996 @default.
- W4213026610 hasConceptScore W4213026610C2778690821 @default.
- W4213026610 hasConceptScore W4213026610C2779341262 @default.
- W4213026610 hasConceptScore W4213026610C502942594 @default.
- W4213026610 hasConceptScore W4213026610C529295009 @default.
- W4213026610 hasConceptScore W4213026610C534529494 @default.
- W4213026610 hasConceptScore W4213026610C54355233 @default.
- W4213026610 hasConceptScore W4213026610C59822182 @default.
- W4213026610 hasConceptScore W4213026610C71924100 @default.
- W4213026610 hasConceptScore W4213026610C86803240 @default.
- W4213026610 hasConceptScore W4213026610C87568996 @default.
- W4213026610 hasConceptScore W4213026610C8891405 @default.
- W4213026610 hasLocation W42130266101 @default.
- W4213026610 hasOpenAccess W4213026610 @default.
- W4213026610 hasPrimaryLocation W42130266101 @default.
- W4213026610 hasRelatedWork W1942876 @default.
- W4213026610 hasRelatedWork W27372507 @default.
- W4213026610 hasRelatedWork W2965569 @default.
- W4213026610 hasRelatedWork W30538912 @default.
- W4213026610 hasRelatedWork W32172285 @default.
- W4213026610 hasRelatedWork W33965020 @default.
- W4213026610 hasRelatedWork W35455931 @default.
- W4213026610 hasRelatedWork W38829615 @default.
- W4213026610 hasRelatedWork W44154923 @default.
- W4213026610 hasRelatedWork W5224877 @default.
- W4213026610 isParatext "false" @default.
- W4213026610 isRetracted "false" @default.
- W4213026610 workType "article" @default.