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• W4213036695 abstract "Coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a real challenge for health-care systems worldwide. Male sex, older age and the coexistence of chronic comorbidities have been described as the most relevant conditions associated with a worse prognosis. Early reports suggested that hypertension might represent a risk factor for susceptibility to SARS-CoV-2 infection, a more severe course of COVID-19 and increased COVID-19-related deaths. Nevertheless, the independent role of hypertension remains under debate, since hypertension is often associated with the older age and other cardiovascular (CV) risk factors in the general population, which may also contribute to the SARS-Cov-2 infection and COVID-19. Moreover, the role of antihypertensive drugs, primarily angiotensin-converting inhibitors (ACEIs) and ARBs (angiotensin receptor blockers) in COVID-19 development and outcome appears controversial. Indeed, preclinical studies using these classes of drugs have suggested a potential upregulation of angiotensin-converting-enzyme 2 (ACE2) which is the key binding receptor promoting cell entry of SARS-CoV-2 in the organism. Renin-angiotensin system (RAS) blockers may potentially upregulate ACE2, hence, it has been initially hypothesized that these agents might contribute to a higher risk of SARS-CoV-2 infection and progressive course of COVID-19. However, several clinical reports do not support a detrimental role of RAS blockers in COVID-19, and an intense debate about the withdrawal or maintenance of chronic therapy with ACEi/ARB has been developed. In this review we will discuss the available evidence on the role of hypertension and antihypertensive drugs on SARS-CoV-2 infection and COVID-19 development." @default.
• W4213036695 created "2022-02-24" @default.
• W4213036695 creator A5020814480 @default.
• W4213036695 creator A5031769855 @default.
• W4213036695 creator A5080134641 @default.
• W4213036695 date "2022-02-20" @default.
• W4213036695 modified "2023-10-13" @default.
• W4213036695 title "Hypertension and COVID-19: Current Evidence and Perspectives" @default.
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• W4213036695 cites W2034426742 @default.
• W4213036695 cites W2045052478 @default.
• W4213036695 cites W2120215319 @default.
• W4213036695 cites W2129812418 @default.
• W4213036695 cites W2143146725 @default.
• W4213036695 cites W2159415544 @default.
• W4213036695 cites W2168671157 @default.
• W4213036695 cites W2396221546 @default.
• W4213036695 cites W2539850032 @default.
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• W4213036695 doi "https://doi.org/10.1007/s40292-022-00506-9" @default.
• W4213036695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35184271" @default.
• W4213036695 hasPublicationYear "2022" @default.
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