FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213039518> ?p ?o ?g. }

• W4213039518 endingPage "101" @default.
• W4213039518 startingPage "99" @default.
• W4213039518 abstract "Abstract Background In liver transplantation (LT) for PSC, pre-transplant colectomy may lower the risk of PSC recurrence (rPSC), and well-controlled or lack of IBD may protect against rPSC, however, these findings are not consistent across all studies. It is unknown whether recipient/donor sex plays a role in rPSC. Aims To study factors associated with PSC recurrence in the post-transplant population. Methods This is a retrospective study on adults who received an LT for PSC in Halifax NS from 1985 to 2020. Graft and patient outcomes are analyzed by logistic regression models. Results A total of 92 patients underwent deceased donor LT for PSC with a mean follow-up time of 9.2 yrs (SD 7.1). Fifty-three remain active in the program, 2 were lost to follow up and 37 died. The mean age at transplant was 43 (SD13, range 18.9–67.8). Seven patients had a second transplant. The five- and 10-year patient survival rate of the entire cohort was 78.7% and 66% respectively. In the active cohort, the prevalence of rPSC was 23.5% (12/51). Retransplantation for rPSC occurred in 8.3% (1/12). The prevalence of IBD was 82.4% (42/51), consisted of ulcerative pancolitis (64.7%, 33/51), ulcerative proctitis (3.9%), left-sided UC (2%) and Crohn’s disease (9.8%). Males are much more likely than females to undergo a colectomy at any time (OR 5.5, 95% CI 1.07–28.22, p 0.041). Refractory IBD was the predominant indication for a colectomy (10/16), followed by dysplasia or colon cancer (6/16). In the post-transplant period, 69% had stable IBD without therapy escalation, 11.9% were escalated to a biologic, 19% underwent a colectomy for active IBD symptoms. Pre-transplant colectomy negatively predicted rPSC, in this subgroup 0% (0/6) developed rPSC. Neither recipient sex (OR 1.14, 95% CI 0.26–5.0, p 0.86) or recipient age predicted the likelihood of rPSC. There was no association between donor sex on rPSC (OR 1.25, 95% CI 0.30–5.27, p 0.76). A trend towards increased rPSC was observed in male donors to female recipients versus female-to-female transplants (OR 6, 95% CI 0.33–107.42, p 0.224). Overall, having a post-transplant colectomy, subtotal or total, irrespective of timing, did not significantly impact rPSC (OR 0.389, 95% CI 0.09–1.66, p 0.20). Diagnosis of IBD was not associated with an increased risk of rPSC (OR 1.21, p 0.83). Conclusions Several factors were associated with rPSC after liver transplant in patients with PSC and IBD, pre-transplant colectomy was found to be protective, male donor to female recipient was a potential risk factor. It is important to study these factors in multi-centered cohorts to understand the pathogenesis of PSC. Pre-transplant total colectomy may be beneficial for several reasons, reducing rPSC, controlling IBD activities, and lowering dysplasia and colon cancer rates in the post-transplant population. Funding Agencies None" @default.
• W4213039518 created "2022-02-24" @default.
• W4213039518 creator A5040242309 @default.
• W4213039518 creator A5067141465 @default.
• W4213039518 creator A5076278007 @default.
• W4213039518 creator A5079973794 @default.
• W4213039518 creator A5088458786 @default.
• W4213039518 date "2022-02-21" @default.
• W4213039518 modified "2023-09-27" @default.
• W4213039518 title "A212 LIVER TRANSPLANTATION FOR PRIMARY SCLEROSING CHOLANGITIS (PSC): EXPERIENCE FROM THE LAST THREE DECADES" @default.
• W4213039518 doi "https://doi.org/10.1093/jcag/gwab049.211" @default.
• W4213039518 hasPublicationYear "2022" @default.
• W4213039518 type Work @default.
• W4213039518 citedByCount "0" @default.
• W4213039518 crossrefType "journal-article" @default.
• W4213039518 hasAuthorship W4213039518A5040242309 @default.
• W4213039518 hasAuthorship W4213039518A5067141465 @default.
• W4213039518 hasAuthorship W4213039518A5076278007 @default.
• W4213039518 hasAuthorship W4213039518A5079973794 @default.
• W4213039518 hasAuthorship W4213039518A5088458786 @default.
• W4213039518 hasBestOaLocation W42130395181 @default.
• W4213039518 hasConcept C121608353 @default.
• W4213039518 hasConcept C126322002 @default.
• W4213039518 hasConcept C141071460 @default.
• W4213039518 hasConcept C151956035 @default.
• W4213039518 hasConcept C167135981 @default.
• W4213039518 hasConcept C2776667177 @default.
• W4213039518 hasConcept C2777044582 @default.
• W4213039518 hasConcept C2778435480 @default.
• W4213039518 hasConcept C2779134260 @default.
• W4213039518 hasConcept C2779609443 @default.
• W4213039518 hasConcept C2779810446 @default.
• W4213039518 hasConcept C2780479503 @default.
• W4213039518 hasConcept C2780615123 @default.
• W4213039518 hasConcept C2908647359 @default.
• W4213039518 hasConcept C2911091166 @default.
• W4213039518 hasConcept C526805850 @default.
• W4213039518 hasConcept C71924100 @default.
• W4213039518 hasConcept C72563966 @default.
• W4213039518 hasConcept C90924648 @default.
• W4213039518 hasConcept C99454951 @default.
• W4213039518 hasConceptScore W4213039518C121608353 @default.
• W4213039518 hasConceptScore W4213039518C126322002 @default.
• W4213039518 hasConceptScore W4213039518C141071460 @default.
• W4213039518 hasConceptScore W4213039518C151956035 @default.
• W4213039518 hasConceptScore W4213039518C167135981 @default.
• W4213039518 hasConceptScore W4213039518C2776667177 @default.
• W4213039518 hasConceptScore W4213039518C2777044582 @default.
• W4213039518 hasConceptScore W4213039518C2778435480 @default.
• W4213039518 hasConceptScore W4213039518C2779134260 @default.
• W4213039518 hasConceptScore W4213039518C2779609443 @default.
• W4213039518 hasConceptScore W4213039518C2779810446 @default.
• W4213039518 hasConceptScore W4213039518C2780479503 @default.
• W4213039518 hasConceptScore W4213039518C2780615123 @default.
• W4213039518 hasConceptScore W4213039518C2908647359 @default.
• W4213039518 hasConceptScore W4213039518C2911091166 @default.
• W4213039518 hasConceptScore W4213039518C526805850 @default.
• W4213039518 hasConceptScore W4213039518C71924100 @default.
• W4213039518 hasConceptScore W4213039518C72563966 @default.
• W4213039518 hasConceptScore W4213039518C90924648 @default.
• W4213039518 hasConceptScore W4213039518C99454951 @default.
• W4213039518 hasIssue "Supplement_1" @default.
• W4213039518 hasLocation W42130395181 @default.
• W4213039518 hasLocation W42130395182 @default.
• W4213039518 hasOpenAccess W4213039518 @default.
• W4213039518 hasPrimaryLocation W42130395181 @default.
• W4213039518 hasRelatedWork W2036194976 @default.
• W4213039518 hasRelatedWork W2062132000 @default.
• W4213039518 hasRelatedWork W2112462414 @default.
• W4213039518 hasRelatedWork W2123729936 @default.
• W4213039518 hasRelatedWork W2134342454 @default.
• W4213039518 hasRelatedWork W2401594509 @default.
• W4213039518 hasRelatedWork W2408833031 @default.
• W4213039518 hasRelatedWork W2999879777 @default.
• W4213039518 hasRelatedWork W3098547688 @default.
• W4213039518 hasRelatedWork W4307947091 @default.
• W4213039518 hasVolume "5" @default.
• W4213039518 isParatext "false" @default.
• W4213039518 isRetracted "false" @default.
• W4213039518 workType "article" @default.