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- W4213042364 endingPage "101562" @default.
- W4213042364 startingPage "101562" @default.
- W4213042364 abstract "Pesticides are used extensively to ensure food security for the ever-growing population around the globe. Monocrotophos (MCP) is a low-cost organophosphate pesticide extensively used in Indian agriculture. People received exposure to pesticides occupationally or by other means. Human lungs and skin are the highest exposure locations for pesticides in agricultural activities. The present study aims to decipher the cytotoxicity of monocrotophos on the lung carcinoma and skin keratinocytes cell lines. The representative cancer cell lines A549, human lung adenocarcinoma and HaCaT, human skin keratinocytes cultured under complete media were exposed to different doses of monocrotophos (MCP- 50 μM and MCP-100 μM). Both cells were also cultured under serum-deprived conditions (0% FBS) and provided similar treatment to analyze the toxic responses. In addition, the endpoints associated with cell viability, oxidative stress, cell cycle analysis and micronuclei formations were investigated. Our present study exhibited significant cytotoxic effects of monocrotophos on A549 and HaCaT cells via ROS generation. In addition, the cell cycle arrest in the G0 phase and micronuclei formation finding highlights the upraised effect of monocrotophos (MCP) in serum-deprived samples compared to experimental controls cultured under serum-containing media. Monocrotophos enhanced cytotoxicity in serum-deprived A549 and HaCaT cells through cell viability depletion, ROS generation, cell cycle arrest, and micronuclei formation compared to complete medium (10% FBS)." @default.
- W4213042364 created "2022-02-24" @default.
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- W4213042364 date "2022-06-01" @default.
- W4213042364 modified "2023-10-18" @default.
- W4213042364 title "Serum deprivation enhanced monocrotophos mediated cellular damages in human lung carcinoma and skin keratinocyte" @default.
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- W4213042364 doi "https://doi.org/10.1016/j.genrep.2022.101562" @default.
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