FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213053670> ?p ?o ?g. }

• W4213053670 abstract "CD47 is overexpressed in multiple tumours and plays an important role in immune escape and other biological processes of tumours. However, its role in adamantinomatous craniopharyngioma (ACP) remains unclear. Therefore, we explored the functions of CD47 in ACP.In this study, the expression of CD47 and the infiltration of immune cells in ACP was determined by immunohistochemistry (IHC) or immunofluorescence. Microglia-mediated phagocytosis was analysed using an in vitro phagocytosis assay. Using lentivirus transfection, CD47 was either silenced or overexpressed in primary ACP cells and the biological effects of CD47 on these cells were evaluated in vitro using cell viability, flow cytometry, wound healing, Transwell migration and 3D hydrogel assays. The protein expression levels were analysed by western blotting.Finger-like protrusions, which may be the key factor in the recurrence of ACP, were primarily found in the region of hypothalamic involvement. The expression of CD47 was higher in palisading epithelium compared with stellate reticulum and epithelial whorls. An in vitro phagocytosis assay showed that CD47 blockade could promote microglia-mediated phagocytosis. Functional assays revealed that CD47 promoted the growth, migration and invasion of ACP cells in vitro. Our mechanistic investigations showed that CD47 activated the MAPK/ERK pathway, thereby facilitating the biological behaviour of ACP cells.Here, we demonstrated that CD47 plays an important role in ACP cells, suggesting that CD47 could be a new potential therapeutic target for ACP, and adding to the body of literature a role for the inhibition of MAPK/ERK in ACP." @default.
• W4213053670 created "2022-02-24" @default.
• W4213053670 creator A5008659449 @default.
• W4213053670 creator A5018967503 @default.
• W4213053670 creator A5019013652 @default.
• W4213053670 creator A5029634246 @default.
• W4213053670 creator A5035266865 @default.
• W4213053670 creator A5035269751 @default.
• W4213053670 creator A5039563806 @default.
• W4213053670 creator A5039755846 @default.
• W4213053670 creator A5049087540 @default.
• W4213053670 creator A5081965637 @default.
• W4213053670 date "2022-02-23" @default.
• W4213053670 modified "2023-10-18" @default.
• W4213053670 title "CD47 promotes the proliferation and migration of adamantinomatous craniopharyngioma cells by activating the MAPK/ERK pathway, and CD47 blockade facilitates microglia‐mediated phagocytosis" @default.
• W4213053670 cites W1571042957 @default.
• W4213053670 cites W1759669640 @default.
• W4213053670 cites W1966217032 @default.
• W4213053670 cites W1979333520 @default.
• W4213053670 cites W2050658928 @default.
• W4213053670 cites W2055353648 @default.
• W4213053670 cites W2066374244 @default.
• W4213053670 cites W2072945345 @default.
• W4213053670 cites W2087002642 @default.
• W4213053670 cites W2090895449 @default.
• W4213053670 cites W2105410069 @default.
• W4213053670 cites W2133346943 @default.
• W4213053670 cites W2135540260 @default.
• W4213053670 cites W2158298066 @default.
• W4213053670 cites W2208625206 @default.
• W4213053670 cites W2289935555 @default.
• W4213053670 cites W2472917228 @default.
• W4213053670 cites W2475945271 @default.
• W4213053670 cites W2490862648 @default.
• W4213053670 cites W2497350880 @default.
• W4213053670 cites W2622499649 @default.
• W4213053670 cites W2776869003 @default.
• W4213053670 cites W2784099979 @default.
• W4213053670 cites W2790470415 @default.
• W4213053670 cites W2791328450 @default.
• W4213053670 cites W2891266849 @default.
• W4213053670 cites W2899044337 @default.
• W4213053670 cites W2908891549 @default.
• W4213053670 cites W2920905579 @default.
• W4213053670 cites W2950132225 @default.
• W4213053670 cites W2962094071 @default.
• W4213053670 cites W2987647647 @default.
• W4213053670 cites W2996448448 @default.
• W4213053670 cites W3003310139 @default.
• W4213053670 cites W3003918648 @default.
• W4213053670 cites W3012610662 @default.
• W4213053670 cites W3049120648 @default.
• W4213053670 cites W3089127204 @default.
• W4213053670 cites W3139911415 @default.
• W4213053670 cites W4239718730 @default.
• W4213053670 cites W4362070821 @default.
• W4213053670 doi "https://doi.org/10.1111/nan.12795" @default.
• W4213053670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35156226" @default.
• W4213053670 hasPublicationYear "2022" @default.
• W4213053670 type Work @default.
• W4213053670 citedByCount "6" @default.
• W4213053670 countsByYear W42130536702022 @default.
• W4213053670 countsByYear W42130536702023 @default.
• W4213053670 crossrefType "journal-article" @default.
• W4213053670 hasAuthorship W4213053670A5008659449 @default.
• W4213053670 hasAuthorship W4213053670A5018967503 @default.
• W4213053670 hasAuthorship W4213053670A5019013652 @default.
• W4213053670 hasAuthorship W4213053670A5029634246 @default.
• W4213053670 hasAuthorship W4213053670A5035266865 @default.
• W4213053670 hasAuthorship W4213053670A5035269751 @default.
• W4213053670 hasAuthorship W4213053670A5039563806 @default.
• W4213053670 hasAuthorship W4213053670A5039755846 @default.
• W4213053670 hasAuthorship W4213053670A5049087540 @default.
• W4213053670 hasAuthorship W4213053670A5081965637 @default.
• W4213053670 hasConcept C153911025 @default.
• W4213053670 hasConcept C160448771 @default.
• W4213053670 hasConcept C202751555 @default.
• W4213053670 hasConcept C203014093 @default.
• W4213053670 hasConcept C2776914184 @default.
• W4213053670 hasConcept C2779830541 @default.
• W4213053670 hasConcept C2780104668 @default.
• W4213053670 hasConcept C502942594 @default.
• W4213053670 hasConcept C553184892 @default.
• W4213053670 hasConcept C55493867 @default.
• W4213053670 hasConcept C57074206 @default.
• W4213053670 hasConcept C62478195 @default.
• W4213053670 hasConcept C86803240 @default.
• W4213053670 hasConcept C8891405 @default.
• W4213053670 hasConcept C95444343 @default.
• W4213053670 hasConceptScore W4213053670C153911025 @default.
• W4213053670 hasConceptScore W4213053670C160448771 @default.
• W4213053670 hasConceptScore W4213053670C202751555 @default.
• W4213053670 hasConceptScore W4213053670C203014093 @default.
• W4213053670 hasConceptScore W4213053670C2776914184 @default.
• W4213053670 hasConceptScore W4213053670C2779830541 @default.
• W4213053670 hasConceptScore W4213053670C2780104668 @default.
• W4213053670 hasConceptScore W4213053670C502942594 @default.
• W4213053670 hasConceptScore W4213053670C553184892 @default.
• W4213053670 hasConceptScore W4213053670C55493867 @default.
• W4213053670 hasConceptScore W4213053670C57074206 @default.

• next