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- W4213067590 abstract "Abstract The accumulating experimental evidence indicates that exposure to blue and white LED light leads to damage in the visual system against short-term exposure. Chronic exposure, adaptive responses to light and self-protective mechanisms against LED light exposures need to be explored and would be essential to know the repercussions of LED radiations on vitreous metabolites. A total of 24 male Wistar rats were used in our study, which was divided into four groups (n = 6 in each group). Three groups were exposed to either blue, white, or yellow LED light for 90 days (12:12 light-dark cycle routine) with uniform illumination (450–500 lux). Control rats were maintained under standard laboratory conditions. Post-exposure the vitreous was removed for mass spectrometry and retinal tissues for immunofluorescence and H&E staining. The thickness of the retina decreased in blue and white light exposure animals compared with controls, whereas the yellow light exposure group showed an increase in thickness (p < 0.001). The number of apoptotic cells was significantly lower in controls compared to light-exposed groups (p < 0.001) and (p < 0.001). Altered metabolites were observed in light exposure groups particularly in D-alanine, taurine, D-serin (p < 0.05 and lysine (p < 0.001). The self-protective or reworking system in the chronic light exposure could be dazed and drop the ability to compensate for the defending mechanism. This might fail to maintain the metabolomic structural integrity of the vitreous and retina." @default.
- W4213067590 created "2022-02-24" @default.
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- W4213067590 date "2022-02-18" @default.
- W4213067590 modified "2023-10-15" @default.
- W4213067590 title "The effect of different bands of LED exposure on vitreous metabolites and retinal architecture." @default.
- W4213067590 doi "https://doi.org/10.21203/rs.3.rs-1325637/v1" @default.
- W4213067590 hasPublicationYear "2022" @default.
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