FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213071142> ?p ?o ?g. }

• W4213071142 endingPage "1007" @default.
• W4213071142 startingPage "1007" @default.
• W4213071142 abstract "Genome-wide loss of DNA methylation is commonly observed in human cancers, but its impact on the tumor transcriptome remains ill-defined. Previous studies demonstrated that this epigenetic alteration causes aberrant activation of a germline-specific gene expression program. Here, we examined if DNA hypomethylation in tumors also leads to de-repression of gene clusters with other tissue specificities. To this end, we explored transcriptomic and methylomic datasets from human lung adenocarcinoma (LUAD) cell lines, normal lung, and lung alveolar type II cells, considered as the origin of LUAD. Interestingly, DNA demethylation in LUAD cell lines was associated with activation of not only germline-specific (CG) genes, but also gene clusters displaying specific expression in the gastrointestinal tract (GI), or in stratified epithelia (SE). Consistently, genes from all three clusters showed highly specific patterns of promoter methylation among normal tissues and cell types, and were generally sensitive to induction by a DNA demethylating agent. Analysis of TCGA datasets confirmed that demethylation and activation of CG, GI and SE genes also occurs in vivo in LUAD tumor tissues, in association with global genome hypomethylation. For genes of the GI cluster, we demonstrated that HNF4A is a necessary factor for transcriptional activation following promoter demethylation. Interestingly, expression of several SE genes, in particular FAM83A, correlated with both tumor grade and reduced patient survival. Together, our study uncovers novel cell-type specific gene clusters that become aberrantly activated in LUAD tumors in association with genome-wide hypomethylation." @default.
• W4213071142 created "2022-02-24" @default.
• W4213071142 creator A5003189357 @default.
• W4213071142 creator A5024084593 @default.
• W4213071142 creator A5033570632 @default.
• W4213071142 date "2022-02-16" @default.
• W4213071142 modified "2023-09-30" @default.
• W4213071142 title "Identification of Tissue-Specific Gene Clusters Induced by DNA Demethylation in Lung Adenocarcinoma: More Than Germline Genes" @default.
• W4213071142 cites W1502798824 @default.
• W4213071142 cites W1798731646 @default.
• W4213071142 cites W1974747095 @default.
• W4213071142 cites W1977896930 @default.
• W4213071142 cites W1997031688 @default.
• W4213071142 cites W2012131048 @default.
• W4213071142 cites W2014636111 @default.
• W4213071142 cites W2015933929 @default.
• W4213071142 cites W2017996531 @default.
• W4213071142 cites W2018838463 @default.
• W4213071142 cites W2021341670 @default.
• W4213071142 cites W2029874395 @default.
• W4213071142 cites W2034507075 @default.
• W4213071142 cites W2041013384 @default.
• W4213071142 cites W2041686632 @default.
• W4213071142 cites W2046877892 @default.
• W4213071142 cites W2076154138 @default.
• W4213071142 cites W2083084802 @default.
• W4213071142 cites W2084680588 @default.
• W4213071142 cites W2087083968 @default.
• W4213071142 cites W2093168978 @default.
• W4213071142 cites W2098337213 @default.
• W4213071142 cites W2103789967 @default.
• W4213071142 cites W2106876831 @default.
• W4213071142 cites W2109047753 @default.
• W4213071142 cites W2116646376 @default.
• W4213071142 cites W2117608041 @default.
• W4213071142 cites W2121417064 @default.
• W4213071142 cites W2126000374 @default.
• W4213071142 cites W2131271579 @default.
• W4213071142 cites W2131374955 @default.
• W4213071142 cites W2135908778 @default.
• W4213071142 cites W2138207763 @default.
• W4213071142 cites W2139077902 @default.
• W4213071142 cites W2143658931 @default.
• W4213071142 cites W2147518722 @default.
• W4213071142 cites W2150474342 @default.
• W4213071142 cites W2157854273 @default.
• W4213071142 cites W2179438025 @default.
• W4213071142 cites W2180481128 @default.
• W4213071142 cites W2230320310 @default.
• W4213071142 cites W2259938310 @default.
• W4213071142 cites W2316087605 @default.
• W4213071142 cites W2474707695 @default.
• W4213071142 cites W2509401422 @default.
• W4213071142 cites W2514628397 @default.
• W4213071142 cites W2535716897 @default.
• W4213071142 cites W2551668581 @default.
• W4213071142 cites W2597594016 @default.
• W4213071142 cites W2739174192 @default.
• W4213071142 cites W2885999730 @default.
• W4213071142 cites W2955128668 @default.
• W4213071142 cites W2964849163 @default.
• W4213071142 cites W2979600210 @default.
• W4213071142 cites W2984827653 @default.
• W4213071142 cites W2991775683 @default.
• W4213071142 cites W3012971027 @default.
• W4213071142 cites W3020212197 @default.
• W4213071142 cites W3046017795 @default.
• W4213071142 cites W3083408463 @default.
• W4213071142 cites W3196366428 @default.
• W4213071142 doi "https://doi.org/10.3390/cancers14041007" @default.
• W4213071142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35205751" @default.
• W4213071142 hasPublicationYear "2022" @default.
• W4213071142 type Work @default.
• W4213071142 citedByCount "4" @default.
• W4213071142 countsByYear W42130711422022 @default.
• W4213071142 countsByYear W42130711422023 @default.
• W4213071142 crossrefType "journal-article" @default.
• W4213071142 hasAuthorship W4213071142A5003189357 @default.
• W4213071142 hasAuthorship W4213071142A5024084593 @default.
• W4213071142 hasAuthorship W4213071142A5033570632 @default.
• W4213071142 hasBestOaLocation W42130711421 @default.
• W4213071142 hasConcept C101762097 @default.
• W4213071142 hasConcept C104317684 @default.
• W4213071142 hasConcept C117717151 @default.
• W4213071142 hasConcept C121608353 @default.
• W4213071142 hasConcept C150194340 @default.
• W4213071142 hasConcept C153911025 @default.
• W4213071142 hasConcept C162317418 @default.
• W4213071142 hasConcept C165864922 @default.
• W4213071142 hasConcept C16824249 @default.
• W4213071142 hasConcept C190727270 @default.
• W4213071142 hasConcept C2779277951 @default.
• W4213071142 hasConcept C2781182431 @default.
• W4213071142 hasConcept C33288867 @default.
• W4213071142 hasConcept C41091548 @default.
• W4213071142 hasConcept C502942594 @default.
• W4213071142 hasConcept C54355233 @default.
• W4213071142 hasConcept C86803240 @default.

• next