FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213072011> ?p ?o ?g. }

• W4213072011 endingPage "638" @default.
• W4213072011 startingPage "638" @default.
• W4213072011 abstract "This research aimed to excavate the alternative mechanism of CEBPD on tumor growth and explore the biological significance of the CEBPD/hsa-miR-429/VEGFA axis on angiogenesis in urothelial carcinoma (UC).Quantitative RT-PCR, immunoblotting assay and tube formation examined the effect of hsa-miR-429 mimic or/and inhibitor on VEGFA expression and angiogenesis in CEBPD-overexpressing UC-derived cells. The association between CEBPD, hsa-miR-429, VEGFA and microvascular density (MVD) and clinical outcome were evaluated in 296 patients with UBUC and 340 patients with UTUC, respectively.The increase in the transcript and protein of VEGFA as well as HUVECs tube formation was diminished upon the treatment of hsa-miR-429 mimic in CEBPD-overexpressing BFTC909 and TCCSUP. Nevertheless, the inhibited regulation of hsa-miR-429 mimic on the expression of VEGFA and ability of HUVECs tube formation was rescued by the combined incubation with hsa-miR-429 inhibitor in these two UC-derived cell lines. Furthermore, the clinical correlations showed that the higher level of VEGFA or MVD has a positive correlation with the expression of CEBPD and a negative relation to hsa-miR-429 and leads to tumor aggressiveness with worse disease-specific, metastasis-free survival in UBUC and UTUC cohorts.We decipher the oncogenic mechanism of CEBPD on angiogenesis through the hsa-miR-429 inhibition to stabilize the expression of VEGFA in UC. The novel research unveiled the modulation of the CEBPD/hsa-miR-429/VEGFA axis on the progression of UC and could be accessible to theranostic biomarkers." @default.
• W4213072011 created "2022-02-24" @default.
• W4213072011 creator A5018877988 @default.
• W4213072011 creator A5031206158 @default.
• W4213072011 creator A5041902425 @default.
• W4213072011 creator A5046555304 @default.
• W4213072011 creator A5070326975 @default.
• W4213072011 creator A5073751089 @default.
• W4213072011 creator A5078966533 @default.
• W4213072011 date "2022-02-11" @default.
• W4213072011 modified "2023-09-27" @default.
• W4213072011 title "Angiogenesis Driven by the CEBPD–hsa-miR-429–VEGFA Signaling Axis Promotes Urothelial Carcinoma Progression" @default.
• W4213072011 cites W169084277 @default.
• W4213072011 cites W1822387735 @default.
• W4213072011 cites W1965837640 @default.
• W4213072011 cites W2002763904 @default.
• W4213072011 cites W2008409590 @default.
• W4213072011 cites W2014868363 @default.
• W4213072011 cites W2022149910 @default.
• W4213072011 cites W2071358970 @default.
• W4213072011 cites W2082312233 @default.
• W4213072011 cites W2110266296 @default.
• W4213072011 cites W2130867283 @default.
• W4213072011 cites W2133094954 @default.
• W4213072011 cites W2137005364 @default.
• W4213072011 cites W2138787512 @default.
• W4213072011 cites W2143926802 @default.
• W4213072011 cites W2144397374 @default.
• W4213072011 cites W2151821775 @default.
• W4213072011 cites W2153484787 @default.
• W4213072011 cites W2156845957 @default.
• W4213072011 cites W2167964554 @default.
• W4213072011 cites W2320235820 @default.
• W4213072011 cites W2343498243 @default.
• W4213072011 cites W2494556743 @default.
• W4213072011 cites W2507668509 @default.
• W4213072011 cites W2736520162 @default.
• W4213072011 cites W2742133220 @default.
• W4213072011 cites W2784743320 @default.
• W4213072011 cites W2793094680 @default.
• W4213072011 cites W2805322097 @default.
• W4213072011 cites W2893312319 @default.
• W4213072011 cites W2947260017 @default.
• W4213072011 cites W2976545322 @default.
• W4213072011 cites W2982865643 @default.
• W4213072011 cites W2991095395 @default.
• W4213072011 cites W3052046645 @default.
• W4213072011 cites W3083187254 @default.
• W4213072011 cites W3092277280 @default.
• W4213072011 cites W3120106265 @default.
• W4213072011 cites W3128646645 @default.
• W4213072011 cites W3160424304 @default.
• W4213072011 cites W3195299022 @default.
• W4213072011 cites W4200213902 @default.
• W4213072011 doi "https://doi.org/10.3390/cells11040638" @default.
• W4213072011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35203290" @default.
• W4213072011 hasPublicationYear "2022" @default.
• W4213072011 type Work @default.
• W4213072011 citedByCount "7" @default.
• W4213072011 countsByYear W42130720112022 @default.
• W4213072011 countsByYear W42130720112023 @default.
• W4213072011 crossrefType "journal-article" @default.
• W4213072011 hasAuthorship W4213072011A5018877988 @default.
• W4213072011 hasAuthorship W4213072011A5031206158 @default.
• W4213072011 hasAuthorship W4213072011A5041902425 @default.
• W4213072011 hasAuthorship W4213072011A5046555304 @default.
• W4213072011 hasAuthorship W4213072011A5070326975 @default.
• W4213072011 hasAuthorship W4213072011A5073751089 @default.
• W4213072011 hasAuthorship W4213072011A5078966533 @default.
• W4213072011 hasBestOaLocation W42130720111 @default.
• W4213072011 hasConcept C104317684 @default.
• W4213072011 hasConcept C145059251 @default.
• W4213072011 hasConcept C146285616 @default.
• W4213072011 hasConcept C167734588 @default.
• W4213072011 hasConcept C2777025900 @default.
• W4213072011 hasConcept C2780394083 @default.
• W4213072011 hasConcept C502942594 @default.
• W4213072011 hasConcept C54355233 @default.
• W4213072011 hasConcept C86803240 @default.
• W4213072011 hasConceptScore W4213072011C104317684 @default.
• W4213072011 hasConceptScore W4213072011C145059251 @default.
• W4213072011 hasConceptScore W4213072011C146285616 @default.
• W4213072011 hasConceptScore W4213072011C167734588 @default.
• W4213072011 hasConceptScore W4213072011C2777025900 @default.
• W4213072011 hasConceptScore W4213072011C2780394083 @default.
• W4213072011 hasConceptScore W4213072011C502942594 @default.
• W4213072011 hasConceptScore W4213072011C54355233 @default.
• W4213072011 hasConceptScore W4213072011C86803240 @default.
• W4213072011 hasIssue "4" @default.
• W4213072011 hasLocation W42130720111 @default.
• W4213072011 hasLocation W42130720112 @default.
• W4213072011 hasLocation W42130720113 @default.
• W4213072011 hasLocation W42130720114 @default.
• W4213072011 hasOpenAccess W4213072011 @default.
• W4213072011 hasPrimaryLocation W42130720111 @default.
• W4213072011 hasRelatedWork W2013577132 @default.
• W4213072011 hasRelatedWork W2017781358 @default.
• W4213072011 hasRelatedWork W2120159810 @default.

• next