Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213072053> ?p ?o ?g. }
- W4213072053 abstract "ABSTRACT The SARS-CoV-2 infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID-19 patients may develop a wide spectrum of autoimmune diseases due to reasons not fully understood. Even so, the landscape of autoantibodies induced by SARS-CoV-2 infection remains uncharted territory. To gain more insight, we carried out a comprehensive assessment of autoantibodies known to be linked to diverse autoimmune diseases observed in COVID-19 patients, in a cohort of 248 individuals, of which171 were COVID-19 patients (74 with mild, 65 moderate, and 32 with severe disease) and 77were healthy controls. Dysregulated autoantibody serum levels, characterized mainly by elevated concentrations, occurred mostly in patients with moderate or severe COVID-19 infection, and was accompanied by a progressive disruption of physiologic IgG and IgA autoantibody signatures. A similar perturbation was found in patients with anosmia. Notably, autoantibody levels often accompanied anti-SARS-CoV-2 antibody concentrations, being both indicated by random forest classification as strong predictors of COVID-19 outcome, together with age. Moreover, higher levels of autoantibodies (mainly IgGs) were seen in the elderly with severe disease compared with young COVID-19 patients with severe disease. These findings suggest that the SARS-CoV-2 infection induces a broader loss of self-tolerance than previously thought, providing new ideas for therapeutic interventions." @default.
- W4213072053 created "2022-02-24" @default.
- W4213072053 creator A5001936700 @default.
- W4213072053 creator A5003055046 @default.
- W4213072053 creator A5003331451 @default.
- W4213072053 creator A5006650480 @default.
- W4213072053 creator A5013283252 @default.
- W4213072053 creator A5017467815 @default.
- W4213072053 creator A5017537703 @default.
- W4213072053 creator A5022807899 @default.
- W4213072053 creator A5027531775 @default.
- W4213072053 creator A5031474128 @default.
- W4213072053 creator A5035589955 @default.
- W4213072053 creator A5039374050 @default.
- W4213072053 creator A5041200276 @default.
- W4213072053 creator A5042234356 @default.
- W4213072053 creator A5047996716 @default.
- W4213072053 creator A5049861477 @default.
- W4213072053 creator A5052779020 @default.
- W4213072053 creator A5060461690 @default.
- W4213072053 creator A5063151241 @default.
- W4213072053 creator A5063347657 @default.
- W4213072053 creator A5064862489 @default.
- W4213072053 creator A5065645102 @default.
- W4213072053 creator A5066663966 @default.
- W4213072053 creator A5067744023 @default.
- W4213072053 creator A5074705375 @default.
- W4213072053 creator A5074738902 @default.
- W4213072053 creator A5077380355 @default.
- W4213072053 creator A5088365664 @default.
- W4213072053 creator A5089789116 @default.
- W4213072053 creator A5091207803 @default.
- W4213072053 date "2022-02-18" @default.
- W4213072053 modified "2023-10-18" @default.
- W4213072053 title "Autoantibodies linked to autoimmune diseases associate with COVID-19 outcomes" @default.
- W4213072053 cites W1552769771 @default.
- W4213072053 cites W1609084115 @default.
- W4213072053 cites W1980340571 @default.
- W4213072053 cites W1982437930 @default.
- W4213072053 cites W1984595840 @default.
- W4213072053 cites W1995631973 @default.
- W4213072053 cites W1996743514 @default.
- W4213072053 cites W1998895310 @default.
- W4213072053 cites W2002697968 @default.
- W4213072053 cites W2019825687 @default.
- W4213072053 cites W2020837209 @default.
- W4213072053 cites W2034400748 @default.
- W4213072053 cites W2062637839 @default.
- W4213072053 cites W2074963908 @default.
- W4213072053 cites W2122765600 @default.
- W4213072053 cites W2137640241 @default.
- W4213072053 cites W2156107325 @default.
- W4213072053 cites W2164171324 @default.
- W4213072053 cites W2725171488 @default.
- W4213072053 cites W2751727948 @default.
- W4213072053 cites W2800052271 @default.
- W4213072053 cites W2809605067 @default.
- W4213072053 cites W2885738092 @default.
- W4213072053 cites W2898386703 @default.
- W4213072053 cites W2902679943 @default.
- W4213072053 cites W3000377151 @default.
- W4213072053 cites W3009906937 @default.
- W4213072053 cites W3016401140 @default.
- W4213072053 cites W3028098130 @default.
- W4213072053 cites W3032902005 @default.
- W4213072053 cites W3035618713 @default.
- W4213072053 cites W3037361899 @default.
- W4213072053 cites W3042907391 @default.
- W4213072053 cites W3043369031 @default.
- W4213072053 cites W3088609942 @default.
- W4213072053 cites W3090013546 @default.
- W4213072053 cites W3092605738 @default.
- W4213072053 cites W3094906854 @default.
- W4213072053 cites W3095015875 @default.
- W4213072053 cites W3096975836 @default.
- W4213072053 cites W3100694757 @default.
- W4213072053 cites W3108171365 @default.
- W4213072053 cites W3109460302 @default.
- W4213072053 cites W3114478940 @default.
- W4213072053 cites W3114973927 @default.
- W4213072053 cites W3120392574 @default.
- W4213072053 cites W3121259291 @default.
- W4213072053 cites W3122801838 @default.
- W4213072053 cites W3127676664 @default.
- W4213072053 cites W3128267789 @default.
- W4213072053 cites W3129083220 @default.
- W4213072053 cites W3132728920 @default.
- W4213072053 cites W3133707325 @default.
- W4213072053 cites W3134063336 @default.
- W4213072053 cites W3139445795 @default.
- W4213072053 cites W3153636933 @default.
- W4213072053 cites W3157571221 @default.
- W4213072053 cites W3159543693 @default.
- W4213072053 cites W3160449499 @default.
- W4213072053 cites W3165081558 @default.
- W4213072053 cites W3169942726 @default.
- W4213072053 cites W3173729580 @default.
- W4213072053 cites W3181826393 @default.
- W4213072053 cites W3185764723 @default.
- W4213072053 cites W3186889326 @default.