FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213073114> ?p ?o ?g. }

• W4213073114 abstract "Porcine reproductive and respiratory syndrome virus (PRRSV) infection during late gestation negatively affects fetal development. The objective of this study was to identify the fetal organs most severely impacted following infection, and evaluate the relationship between this response and fetal phenotypes. RNA was extracted from fetal heart, liver, lung, thymus, kidney, spleen, and loin muscle, collected following late gestation viral challenge of pregnant gilts. Initially, gene expression for three cell cycle promoters (CDK1, CDK2, CDK4) and one inhibitor (CDKN1A) were evaluated in biologically extreme phenotypic subsets including gestational age-matched controls (CON), uninfected (UNIF), high-viral load viable (HV-VIA), and high-viral load meconium-stained (HV-MEC) fetuses. There were no differences between CON and UNIF groups for any gene, indicating no impact of maternal infection alone. Relative to CON, high-viral load (HV-VIA, HV-MEC) fetuses showed significant downregulation of at least one CDK gene in all tissues except liver, while CDKN1A was upregulated in all tissues except muscle, with the heart and kidney most severely impacted. Subsequent evaluation of additional genes known to be upregulated following activation of P53 or TGFb/SMAD signaling cascades indicated neither pathway was responsible for the observed increase in CDKN1A. Finally, analysis of heart and kidney from a larger unselected population of infected fetuses from the same animal study showed that serum thyroxin and viral load were highly correlated with the expression of CDKN1A in both tissues. Collectively these results demonstrate the widespread suppression in cell division across all tissues in PRRSV infected fetuses and indicate a non-canonical regulatory mechanism." @default.
• W4213073114 created "2022-02-24" @default.
• W4213073114 creator A5008654383 @default.
• W4213073114 creator A5014958059 @default.
• W4213073114 creator A5031042092 @default.
• W4213073114 creator A5069163302 @default.
• W4213073114 creator A5088599003 @default.
• W4213073114 date "2022-02-21" @default.
• W4213073114 modified "2023-09-27" @default.
• W4213073114 title "Porcine reproductive and respiratory virus 2 infection of the fetus results in multi-organ cell cycle suppression" @default.
• W4213073114 cites W116808744 @default.
• W4213073114 cites W1508417710 @default.
• W4213073114 cites W1531237901 @default.
• W4213073114 cites W1531803131 @default.
• W4213073114 cites W1968404111 @default.
• W4213073114 cites W1970533338 @default.
• W4213073114 cites W1973047647 @default.
• W4213073114 cites W1975737859 @default.
• W4213073114 cites W1984594080 @default.
• W4213073114 cites W1988653989 @default.
• W4213073114 cites W1999650052 @default.
• W4213073114 cites W2003282728 @default.
• W4213073114 cites W2014888968 @default.
• W4213073114 cites W2014921738 @default.
• W4213073114 cites W2018426784 @default.
• W4213073114 cites W2025734020 @default.
• W4213073114 cites W2034259915 @default.
• W4213073114 cites W2040690361 @default.
• W4213073114 cites W2051475667 @default.
• W4213073114 cites W2056352500 @default.
• W4213073114 cites W2070359493 @default.
• W4213073114 cites W2073008636 @default.
• W4213073114 cites W2080939868 @default.
• W4213073114 cites W2082619639 @default.
• W4213073114 cites W2085016751 @default.
• W4213073114 cites W2088111342 @default.
• W4213073114 cites W2090403820 @default.
• W4213073114 cites W2090833395 @default.
• W4213073114 cites W2093569973 @default.
• W4213073114 cites W2097110561 @default.
• W4213073114 cites W2104255920 @default.
• W4213073114 cites W2107061287 @default.
• W4213073114 cites W2116996698 @default.
• W4213073114 cites W2122465299 @default.
• W4213073114 cites W2130408224 @default.
• W4213073114 cites W2138302399 @default.
• W4213073114 cites W2144555231 @default.
• W4213073114 cites W2145731761 @default.
• W4213073114 cites W2146031543 @default.
• W4213073114 cites W2150348717 @default.
• W4213073114 cites W2153486723 @default.
• W4213073114 cites W2155363874 @default.
• W4213073114 cites W2159699229 @default.
• W4213073114 cites W2163794476 @default.
• W4213073114 cites W2164600541 @default.
• W4213073114 cites W2170630161 @default.
• W4213073114 cites W2171170003 @default.
• W4213073114 cites W2272024469 @default.
• W4213073114 cites W2274592070 @default.
• W4213073114 cites W2410973053 @default.
• W4213073114 cites W2583260268 @default.
• W4213073114 cites W2627077408 @default.
• W4213073114 cites W2781472954 @default.
• W4213073114 cites W2903077970 @default.
• W4213073114 cites W2951054304 @default.
• W4213073114 cites W2980632377 @default.
• W4213073114 cites W3008195867 @default.
• W4213073114 cites W3010714596 @default.
• W4213073114 cites W3013295760 @default.
• W4213073114 cites W3094772815 @default.
• W4213073114 cites W3103541249 @default.
• W4213073114 cites W3120681830 @default.
• W4213073114 cites W3207034508 @default.
• W4213073114 cites W4200375933 @default.
• W4213073114 cites W4254687493 @default.
• W4213073114 doi "https://doi.org/10.1186/s13567-022-01030-3" @default.
• W4213073114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35189966" @default.
• W4213073114 hasPublicationYear "2022" @default.
• W4213073114 type Work @default.
• W4213073114 citedByCount "3" @default.
• W4213073114 countsByYear W42130731142022 @default.
• W4213073114 countsByYear W42130731142023 @default.
• W4213073114 crossrefType "journal-article" @default.
• W4213073114 hasAuthorship W4213073114A5008654383 @default.
• W4213073114 hasAuthorship W4213073114A5014958059 @default.
• W4213073114 hasAuthorship W4213073114A5031042092 @default.
• W4213073114 hasAuthorship W4213073114A5069163302 @default.
• W4213073114 hasAuthorship W4213073114A5088599003 @default.
• W4213073114 hasBestOaLocation W42130731141 @default.
• W4213073114 hasConcept C104317684 @default.
• W4213073114 hasConcept C127561419 @default.
• W4213073114 hasConcept C134018914 @default.
• W4213073114 hasConcept C142462285 @default.
• W4213073114 hasConcept C16685009 @default.
• W4213073114 hasConcept C172680121 @default.
• W4213073114 hasConcept C203014093 @default.
• W4213073114 hasConcept C2522874641 @default.
• W4213073114 hasConcept C2779234561 @default.
• W4213073114 hasConcept C2779819720 @default.
• W4213073114 hasConcept C2780091579 @default.

• next