Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213079074> ?p ?o ?g. }
- W4213079074 endingPage "12371" @default.
- W4213079074 startingPage "12366" @default.
- W4213079074 abstract "Fluorescent flipper probes have been introduced recently to image membrane tension in live cells, and strategies to target these probes to specific membranes are emerging. In this context, early endosome (EE) targeting without the use of protein engineering is especially appealing because it translates into a fascinating transport problem. Weakly basic probes, commonly used to track the inside of acidic late endosomes and lysosomes, are poorly retained in EE because they are sufficiently neutralized in weakly acidic EE, thus able to diffuse out. Here, we disclose a rational strategy to target EE using a substituted benzylamine with a higher pKa value as a head group of the flipper probe. The resulting EE flippers are validated for preserved mechanosensitivity, ready for use in biology, particularly to elucidate the mechanics of endocytosis." @default.
- W4213079074 created "2022-02-24" @default.
- W4213079074 creator A5026059999 @default.
- W4213079074 creator A5036898198 @default.
- W4213079074 creator A5037906302 @default.
- W4213079074 creator A5057541085 @default.
- W4213079074 creator A5066285072 @default.
- W4213079074 creator A5074736526 @default.
- W4213079074 date "2021-04-26" @default.
- W4213079074 modified "2023-09-29" @default.
- W4213079074 title "Fluorescent Membrane Tension Probes for Early Endosomes" @default.
- W4213079074 cites W1188934410 @default.
- W4213079074 cites W1753434211 @default.
- W4213079074 cites W1971060242 @default.
- W4213079074 cites W1974491454 @default.
- W4213079074 cites W1981249397 @default.
- W4213079074 cites W1990122271 @default.
- W4213079074 cites W1996746330 @default.
- W4213079074 cites W2005294076 @default.
- W4213079074 cites W2005496979 @default.
- W4213079074 cites W2009037782 @default.
- W4213079074 cites W2026227022 @default.
- W4213079074 cites W2031715022 @default.
- W4213079074 cites W2032240634 @default.
- W4213079074 cites W2037563014 @default.
- W4213079074 cites W2047622488 @default.
- W4213079074 cites W2048305477 @default.
- W4213079074 cites W2050442651 @default.
- W4213079074 cites W2058614432 @default.
- W4213079074 cites W2069314886 @default.
- W4213079074 cites W2069888185 @default.
- W4213079074 cites W2074879816 @default.
- W4213079074 cites W2084257914 @default.
- W4213079074 cites W2088084755 @default.
- W4213079074 cites W2095127491 @default.
- W4213079074 cites W2098485753 @default.
- W4213079074 cites W2101902313 @default.
- W4213079074 cites W2104534420 @default.
- W4213079074 cites W2125872855 @default.
- W4213079074 cites W2144118351 @default.
- W4213079074 cites W2145619979 @default.
- W4213079074 cites W2152238363 @default.
- W4213079074 cites W2163006504 @default.
- W4213079074 cites W2164188238 @default.
- W4213079074 cites W2168044659 @default.
- W4213079074 cites W2239778944 @default.
- W4213079074 cites W2276102061 @default.
- W4213079074 cites W2315483828 @default.
- W4213079074 cites W2320213632 @default.
- W4213079074 cites W2329978252 @default.
- W4213079074 cites W2511583688 @default.
- W4213079074 cites W2512702739 @default.
- W4213079074 cites W2535693592 @default.
- W4213079074 cites W2568046654 @default.
- W4213079074 cites W2577724645 @default.
- W4213079074 cites W2617380759 @default.
- W4213079074 cites W2623799194 @default.
- W4213079074 cites W2738342839 @default.
- W4213079074 cites W2751542532 @default.
- W4213079074 cites W2766372507 @default.
- W4213079074 cites W2770254472 @default.
- W4213079074 cites W2788197191 @default.
- W4213079074 cites W2797019411 @default.
- W4213079074 cites W2797696581 @default.
- W4213079074 cites W2801330678 @default.
- W4213079074 cites W2806429129 @default.
- W4213079074 cites W2806506567 @default.
- W4213079074 cites W2887768367 @default.
- W4213079074 cites W2888670687 @default.
- W4213079074 cites W2903633305 @default.
- W4213079074 cites W2903827925 @default.
- W4213079074 cites W2905528225 @default.
- W4213079074 cites W2911294518 @default.
- W4213079074 cites W2914783351 @default.
- W4213079074 cites W2923567758 @default.
- W4213079074 cites W2928521349 @default.
- W4213079074 cites W2944631658 @default.
- W4213079074 cites W2945904299 @default.
- W4213079074 cites W2949601105 @default.
- W4213079074 cites W2958899680 @default.
- W4213079074 cites W2965513554 @default.
- W4213079074 cites W2966356162 @default.
- W4213079074 cites W2967044247 @default.
- W4213079074 cites W2968470612 @default.
- W4213079074 cites W2969881351 @default.
- W4213079074 cites W2970699026 @default.
- W4213079074 cites W2978407315 @default.
- W4213079074 cites W2979864601 @default.
- W4213079074 cites W2985009271 @default.
- W4213079074 cites W2996586116 @default.
- W4213079074 cites W2997929757 @default.
- W4213079074 cites W3000011955 @default.
- W4213079074 cites W3005105119 @default.
- W4213079074 cites W3013176829 @default.
- W4213079074 cites W3023555211 @default.
- W4213079074 cites W3033948802 @default.
- W4213079074 cites W3034580159 @default.
- W4213079074 cites W3042296446 @default.