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• W4213087523 startingPage "440" @default.
• W4213087523 abstract "Recombination creates mosaic genomes containing regions with mixed ancestry, and the accumulation of such events over time can complicate greatly many aspects of evolutionary inference. Here, we developed a sliding window bootstrap (SWB) method to generate genomic bootstrap (GB) barcodes to highlight the regions supporting phylogenetic relationships. The method was applied to an alignment of 56 sarbecoviruses, including SARS-CoV and SARS-CoV-2, responsible for the SARS epidemic and COVID-19 pandemic, respectively. The SWB analyses were also used to construct a consensus tree showing the most reliable relationships and better interpret hidden phylogenetic signals. Our results revealed that most relationships were supported by just a few genomic regions and confirmed that three divergent lineages could be found in bats from Yunnan: SCoVrC, which groups SARS-CoV related coronaviruses from China; SCoV2rC, which includes SARS-CoV-2 related coronaviruses from Southeast Asia and Yunnan; and YunSar, which contains a few highly divergent viruses recently described in Yunnan. The GB barcodes showed evidence for ancient recombination between SCoV2rC and YunSar genomes, as well as more recent recombination events between SCoVrC and SCoV2rC genomes. The recombination and phylogeographic patterns suggest a strong host-dependent selection of the viral RNA-dependent RNA polymerase. In addition, SARS-CoV-2 appears as a mosaic genome composed of regions sharing recent ancestry with three bat SCoV2rCs from Yunnan (RmYN02, RpYN06, and RaTG13) or related to more ancient ancestors in bats from Yunnan and Southeast Asia. Finally, our results suggest that viral circular RNAs may be key molecules for the mechanism of recombination." @default.
• W4213087523 created "2022-02-24" @default.
• W4213087523 creator A5016528772 @default.
• W4213087523 creator A5044259387 @default.
• W4213087523 creator A5060617400 @default.
• W4213087523 date "2022-02-21" @default.
• W4213087523 modified "2023-10-14" @default.
• W4213087523 title "Genomic Bootstrap Barcodes and Their Application to Study the Evolution of Sarbecoviruses" @default.
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• W4213087523 doi "https://doi.org/10.3390/v14020440" @default.
• W4213087523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35216033" @default.
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