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- W4213089469 abstract "During development, cells progress from a pluripotent state to a more restricted fate within a particular germ layer. However, cranial neural crest cells (CNCCs), a transient cell population that generates most of the craniofacial skeleton, have much broader differentiation potential than their ectodermal lineage of origin. Here, we identify a neuroepithelial precursor population characterized by expression of canonical pluripotency transcription factors that gives rise to CNCCs and is essential for craniofacial development. Pluripotency factor Oct4 is transiently reactivated in CNCCs and is required for the subsequent formation of ectomesenchyme. Furthermore, open chromatin landscapes of Oct4+ CNCC precursors resemble those of epiblast stem cells, with additional features suggestive of priming for mesenchymal programs. We propose that CNCCs expand their developmental potential through a transient reacquisition of molecular signatures of pluripotency.Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. PMID: 33542111 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: R35 GM131757 Howard Hughes Medical Institute, United States" @default.
- W4213089469 created "2022-02-24" @default.
- W4213089469 creator A5049883489 @default.
- W4213089469 date "2021-05-11" @default.
- W4213089469 modified "2023-09-26" @default.
- W4213089469 title "Faculty Opinions recommendation of Reactivation of the pluripotency program precedes formation of the cranial neural crest." @default.
- W4213089469 doi "https://doi.org/10.3410/f.739482240.793585490" @default.
- W4213089469 hasPublicationYear "2021" @default.
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