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- W4213089576 endingPage "566" @default.
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- W4213089576 abstract "Cohesin mediates chromatin loop formation across the genome by extruding chromatin between convergently oriented CTCF-binding elements. Recent studies indicate that cohesin-mediated loop extrusion in developing B cells presents immunoglobulin heavy chain (Igh) variable (V), diversity (D) and joining (J) gene segments to RAG endonuclease through a process referred to as RAG chromatin scanning. RAG initiates V(D)J recombinational joining of these gene segments to generate the large number of different Igh variable region exons that are required for immune responses to diverse pathogens. Antigen-activated mature B cells also use chromatin loop extrusion to mediate the synapsis, breakage and end joining of switch regions flanking Igh constant region exons during class-switch recombination, which allows for the expression of different antibody constant region isotypes that optimize the functions of antigen-specific antibodies to eliminate pathogens. Here, we review recent advances in our understanding of chromatin loop extrusion during V(D)J recombination and class-switch recombination at the Igh locus. Alt and colleagues review recent advances in our understanding of the mechanistic role of cohesin-mediated chromatin loop extrusion in V(D)J recombination and class-switch recombination at the immunoglobulin heavy chain locus." @default.
- W4213089576 created "2022-02-24" @default.
- W4213089576 creator A5002439907 @default.
- W4213089576 creator A5015698099 @default.
- W4213089576 creator A5033821931 @default.
- W4213089576 creator A5042221842 @default.
- W4213089576 creator A5085508819 @default.
- W4213089576 date "2022-02-15" @default.
- W4213089576 modified "2023-10-16" @default.
- W4213089576 title "The role of chromatin loop extrusion in antibody diversification" @default.
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