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- W4213093419 abstract "Abstract Neuropeptides act mostly on a class of G-protein coupled receptors, and play a fundamental role in the functions of neural circuits underlying behaviors. However, the functions of neuropeptide receptors are poorly understood. Here, we used the mollusc model system Aplysia and microinjected the exogenous neuropeptide receptor apATRPR ( Aplysia Allatotropin-related peptide receptor) with an expression vector (pNEX3) into Aplysia neurons that did not express the receptor. Physiological experiments demonstrated that apATRPR could mediate the excitability increase activated by its ligand, apATRP ( Aplysia Allatotropin-related peptide), in the Aplysia neurons that now express the receptor. This study provides the first definitive evidence for a physiological function of a neuropeptide receptor in molluscan animals." @default.
- W4213093419 created "2022-02-24" @default.
- W4213093419 creator A5007992168 @default.
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- W4213093419 creator A5081125297 @default.
- W4213093419 date "2022-02-14" @default.
- W4213093419 modified "2023-10-16" @default.
- W4213093419 title "Functional characterization of a neuropeptide receptor exogenously expressed in Aplysia neurons" @default.
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- W4213093419 doi "https://doi.org/10.1101/2022.02.14.480444" @default.
- W4213093419 hasPublicationYear "2022" @default.