FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213094828> ?p ?o ?g. }

• W4213094828 abstract "Abstract France has a population with extensive internal fine-structure; and while public imputation reference panels contain an abundance of European genomes, there include few French genomes. Intuitively, using a ‘study specific panel’ (SSP) for France would therefore likely be beneficial. To investigate, we imputed 550 French individuals using either the University of Michigan imputation server with the Haplotype Reference Consortium panel, or in-house using an SSP of 850 whole-genome sequenced French individuals. With approximate geo-localization of both our target and SSP individuals we are able to pinpoint different scenarios where SSP-based imputation would be preferred over server-based imputation or vice-versa. We could also show to a high degree of resolution how the proximity of the reference panel to a target individual determined the accuracy of both haplotype phasing and genotype imputation. Previous comparisons of different strategies have shown the benefits of combining public reference panels with SSPs. Getting the best out of both resources simultaneously is unfortunately impractical. We put forward a pragmatic solution where server-based and SSP-based imputation outcomes can be combined based on comparing posterior genotype probabilities. Such an approach can give a level of imputation accuracy markedly in excess of what could be achieved with either strategy alone." @default.
• W4213094828 created "2022-02-24" @default.
• W4213094828 creator A5011453874 @default.
• W4213094828 creator A5027469318 @default.
• W4213094828 creator A5035511168 @default.
• W4213094828 creator A5041253450 @default.
• W4213094828 creator A5049107218 @default.
• W4213094828 creator A5058691508 @default.
• W4213094828 creator A9999999999 @default.
• W4213094828 date "2022-02-19" @default.
• W4213094828 modified "2023-09-27" @default.
• W4213094828 title "Can imputation in a European country be improved by local reference panels? The example of France" @default.
• W4213094828 cites W1907868928 @default.
• W4213094828 cites W1955438083 @default.
• W4213094828 cites W1962960380 @default.
• W4213094828 cites W1965618186 @default.
• W4213094828 cites W1980792369 @default.
• W4213094828 cites W2010284333 @default.
• W4213094828 cites W2011671834 @default.
• W4213094828 cites W2026884584 @default.
• W4213094828 cites W2056155495 @default.
• W4213094828 cites W2080873675 @default.
• W4213094828 cites W2087036932 @default.
• W4213094828 cites W2098066250 @default.
• W4213094828 cites W2104549677 @default.
• W4213094828 cites W2108889957 @default.
• W4213094828 cites W2129559300 @default.
• W4213094828 cites W2144162032 @default.
• W4213094828 cites W2147477044 @default.
• W4213094828 cites W2148808569 @default.
• W4213094828 cites W2153178054 @default.
• W4213094828 cites W2155261257 @default.
• W4213094828 cites W2156719275 @default.
• W4213094828 cites W2163705275 @default.
• W4213094828 cites W2166501262 @default.
• W4213094828 cites W2167964622 @default.
• W4213094828 cites W2216458865 @default.
• W4213094828 cites W2510973425 @default.
• W4213094828 cites W2511515754 @default.
• W4213094828 cites W2527677381 @default.
• W4213094828 cites W2529241974 @default.
• W4213094828 cites W2560652310 @default.
• W4213094828 cites W2563835520 @default.
• W4213094828 cites W2602374858 @default.
• W4213094828 cites W2605706957 @default.
• W4213094828 cites W2752425944 @default.
• W4213094828 cites W2783456390 @default.
• W4213094828 cites W2792381148 @default.
• W4213094828 cites W2883621824 @default.
• W4213094828 cites W2921027352 @default.
• W4213094828 cites W2949960474 @default.
• W4213094828 cites W2952113787 @default.
• W4213094828 cites W2954339211 @default.
• W4213094828 cites W2979925378 @default.
• W4213094828 cites W2989551476 @default.
• W4213094828 cites W2989703121 @default.
• W4213094828 cites W2990059271 @default.
• W4213094828 cites W2996024184 @default.
• W4213094828 cites W3004717443 @default.
• W4213094828 cites W3033457525 @default.
• W4213094828 cites W3041064250 @default.
• W4213094828 cites W3120295425 @default.
• W4213094828 cites W3139303615 @default.
• W4213094828 cites W4210521419 @default.
• W4213094828 doi "https://doi.org/10.1101/2022.02.17.480829" @default.
• W4213094828 hasPublicationYear "2022" @default.
• W4213094828 type Work @default.
• W4213094828 citedByCount "4" @default.
• W4213094828 countsByYear W42130948282022 @default.
• W4213094828 countsByYear W42130948282023 @default.
• W4213094828 crossrefType "posted-content" @default.
• W4213094828 hasAuthorship W4213094828A5011453874 @default.
• W4213094828 hasAuthorship W4213094828A5027469318 @default.
• W4213094828 hasAuthorship W4213094828A5035511168 @default.
• W4213094828 hasAuthorship W4213094828A5041253450 @default.
• W4213094828 hasAuthorship W4213094828A5049107218 @default.
• W4213094828 hasAuthorship W4213094828A5058691508 @default.
• W4213094828 hasAuthorship W4213094828A9999999999 @default.
• W4213094828 hasBestOaLocation W42130948281 @default.
• W4213094828 hasConcept C104317684 @default.
• W4213094828 hasConcept C105795698 @default.
• W4213094828 hasConcept C119857082 @default.
• W4213094828 hasConcept C124101348 @default.
• W4213094828 hasConcept C135763542 @default.
• W4213094828 hasConcept C144024400 @default.
• W4213094828 hasConcept C149782125 @default.
• W4213094828 hasConcept C149923435 @default.
• W4213094828 hasConcept C153209595 @default.
• W4213094828 hasConcept C197754878 @default.
• W4213094828 hasConcept C2908647359 @default.
• W4213094828 hasConcept C33923547 @default.
• W4213094828 hasConcept C41008148 @default.
• W4213094828 hasConcept C54355233 @default.
• W4213094828 hasConcept C58041806 @default.
• W4213094828 hasConcept C86803240 @default.
• W4213094828 hasConcept C9357733 @default.
• W4213094828 hasConcept C97425143 @default.
• W4213094828 hasConceptScore W4213094828C104317684 @default.
• W4213094828 hasConceptScore W4213094828C105795698 @default.
• W4213094828 hasConceptScore W4213094828C119857082 @default.

• next