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- W4213098526 abstract "The protective effect of the Na + /H + exchange inhibitor HOE 694 was tested in porcine hearts subjected to 45 min of regional ischemia and 24 h of reperfusion. The compound (3 mg/kg) was intravenously injected in 6 pigs each either 10 min before ischemia (group A) or 10 min before reperfusion (group B). Six animals served as controls. Apart from the main end-points, infarct size and regional systolic shortening, the effect of HOE 694 on global hemodynamic parameters which included coronary blood flow and coronary venous oxygen saturation was evaluated. Although the Na + IH + exchange inhibitor did not affect global hemodynamics, preischemic treatment with HOE 694 decreased infarct size from 65 ± 18% (control group) to 12 ± 9% (p < 0.01) and improved systolic shortening from 8 ± 6% (control group) to 28 ± 9% P < 0.02). In addition, increase in heart rate and myocardial contracture during early reperfusion were significantly attenuated in group A. Treatment of group B did not exhibit protective effects. Na + /H + exchange inhibition is a very protective means in myocardial ischemia and reperfusion when administered before ischemia. In this model, it was ineffective when given before reperfusion." @default.
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- W4213098526 date "1995-02-01" @default.
- W4213098526 modified "2023-10-18" @default.
- W4213098526 title "1005-81 Myocardial Protection by Na + /H + Exchange Inhibition in Ischemic, Reperfused Porcine Hearts" @default.
- W4213098526 doi "https://doi.org/10.1016/0735-1097(95)92933-v" @default.
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