Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213123536> ?p ?o ?g. }
- W4213123536 abstract "The embryonic mouse brain undergoes drastic changes in establishing basic anatomical compartments and laying out major axonal connections of the developing brain. Correlating anatomical changes with gene-expression patterns is an essential step toward understanding the mechanisms regulating brain development. Traditionally, this is done in a cross-sectional manner, but the dynamic nature of development calls for probing gene-neuroanatomy interactions in a combined spatiotemporal domain. Here, we present a four-dimensional (4D) spatiotemporal continuum of the embryonic mouse brain from E10.5 to E15.5 reconstructed from diffusion magnetic resonance microscopy (dMRM) data. This study achieved unprecedented high-definition dMRM at 30- to 35-µm isotropic resolution, and together with computational neuroanatomy techniques, we revealed both morphological and microscopic changes in the developing brain. We transformed selected gene-expression data to this continuum and correlated them with the dMRM-based neuroanatomical changes in embryonic brains. Within the continuum, we identified distinct developmental modes comprising regional clusters that shared developmental trajectories and similar gene-expression profiles. Our results demonstrate how this 4D continuum can be used to examine spatiotemporal gene-neuroanatomical interactions by connecting upstream genetic events with anatomical changes that emerge later in development. This approach would be useful for large-scale analysis of the cooperative roles of key genes in shaping the developing brain." @default.
- W4213123536 created "2022-02-24" @default.
- W4213123536 creator A5010562965 @default.
- W4213123536 creator A5023604056 @default.
- W4213123536 creator A5027397408 @default.
- W4213123536 creator A5032007498 @default.
- W4213123536 creator A5033151214 @default.
- W4213123536 creator A5037116171 @default.
- W4213123536 creator A5038655676 @default.
- W4213123536 creator A5058150411 @default.
- W4213123536 creator A5059285918 @default.
- W4213123536 creator A5059342248 @default.
- W4213123536 creator A5077721872 @default.
- W4213123536 date "2022-02-14" @default.
- W4213123536 modified "2023-10-15" @default.
- W4213123536 title "A diffusion MRI-based spatiotemporal continuum of the embryonic mouse brain for probing gene–neuroanatomy connections" @default.
- W4213123536 cites W140226862 @default.
- W4213123536 cites W1491943710 @default.
- W4213123536 cites W1503893179 @default.
- W4213123536 cites W1904837397 @default.
- W4213123536 cites W1939237254 @default.
- W4213123536 cites W1963743487 @default.
- W4213123536 cites W1965626594 @default.
- W4213123536 cites W1974478434 @default.
- W4213123536 cites W1978957620 @default.
- W4213123536 cites W1983535614 @default.
- W4213123536 cites W1986897915 @default.
- W4213123536 cites W1990820027 @default.
- W4213123536 cites W1995021884 @default.
- W4213123536 cites W1996453470 @default.
- W4213123536 cites W1998517217 @default.
- W4213123536 cites W2000607341 @default.
- W4213123536 cites W2003572485 @default.
- W4213123536 cites W2006557707 @default.
- W4213123536 cites W2006983329 @default.
- W4213123536 cites W2011524735 @default.
- W4213123536 cites W2011833952 @default.
- W4213123536 cites W2014651004 @default.
- W4213123536 cites W2029262926 @default.
- W4213123536 cites W2034252184 @default.
- W4213123536 cites W2037605112 @default.
- W4213123536 cites W2041849406 @default.
- W4213123536 cites W2051020842 @default.
- W4213123536 cites W2053999216 @default.
- W4213123536 cites W2057849519 @default.
- W4213123536 cites W2059086372 @default.
- W4213123536 cites W2068603597 @default.
- W4213123536 cites W2069558079 @default.
- W4213123536 cites W2078873544 @default.
- W4213123536 cites W2080566879 @default.
- W4213123536 cites W2080866586 @default.
- W4213123536 cites W2084233122 @default.
- W4213123536 cites W2085155032 @default.
- W4213123536 cites W2087203385 @default.
- W4213123536 cites W2092223956 @default.
- W4213123536 cites W2092811935 @default.
- W4213123536 cites W2092934821 @default.
- W4213123536 cites W2095064889 @default.
- W4213123536 cites W2097996483 @default.
- W4213123536 cites W2100801632 @default.
- W4213123536 cites W2105011233 @default.
- W4213123536 cites W2105671340 @default.
- W4213123536 cites W2106919606 @default.
- W4213123536 cites W2110904144 @default.
- W4213123536 cites W2115245436 @default.
- W4213123536 cites W2116532199 @default.
- W4213123536 cites W2123491442 @default.
- W4213123536 cites W2124649657 @default.
- W4213123536 cites W2127220436 @default.
- W4213123536 cites W2129381979 @default.
- W4213123536 cites W2131486024 @default.
- W4213123536 cites W2135210816 @default.
- W4213123536 cites W2139158372 @default.
- W4213123536 cites W2142596508 @default.
- W4213123536 cites W2143326696 @default.
- W4213123536 cites W2145132952 @default.
- W4213123536 cites W2150926065 @default.
- W4213123536 cites W2152704239 @default.
- W4213123536 cites W2154431984 @default.
- W4213123536 cites W2154641154 @default.
- W4213123536 cites W2156295356 @default.
- W4213123536 cites W2165287928 @default.
- W4213123536 cites W2168866216 @default.
- W4213123536 cites W2170167891 @default.
- W4213123536 cites W2260422212 @default.
- W4213123536 cites W2327847910 @default.
- W4213123536 cites W2753247456 @default.
- W4213123536 cites W2783062854 @default.
- W4213123536 cites W2805189754 @default.
- W4213123536 cites W2810744002 @default.
- W4213123536 cites W2905058438 @default.
- W4213123536 cites W2921452976 @default.
- W4213123536 cites W2951882476 @default.
- W4213123536 cites W2965541130 @default.
- W4213123536 cites W3021105102 @default.
- W4213123536 cites W3037329734 @default.
- W4213123536 cites W3039283352 @default.
- W4213123536 cites W3120554937 @default.
- W4213123536 cites W3184208286 @default.
- W4213123536 doi "https://doi.org/10.1073/pnas.2111869119" @default.