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• W4213135975 abstract "Long-term spaceflight has been proved to cause physical impairments such as motor, cardiovascular and endocrine functions in astronauts. But psychological effects such as mood and social interaction are less well understood. Besides, there are conflicting accounts of their effects on cognitive function. Thus in this study, we exposed mice (18-21 g) to 28-day simulate microgravity and social isolation (SM+SI) and examined its effects on mood, social interaction and cognitive function. We found that four weeks of SM+SI exposure resulted in emotional and specific social barriers, which may be associated with loss of neurons and decreased dendritic spine density in the medial prefrontal cortex. Unexpectedly, SM+SI enhanced the short and long-term cognitive abilities of mice, which may be related to the anti-apoptotic effect of SM+SI regulating the level of apoptotic factors in the hippocampus. These results indicates that SM+SI, as chronic stressor, can induce the body to establish effective coping strategies to enhance individuals' cognitive ability; on the other hand, long-term exposure to SM+SI causes emotional/social barriers. This study further demonstrates SM+SI causes different effects in a brain-region specific manner. Current findings provide a theoretical basis for understanding how SM+SI acts on the brain structure to influence mental health, and may be useful for designing effective prevention for those, including the astronauts, exposed to microgravity." @default.
• W4213135975 created "2022-02-24" @default.
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• W4213135975 date "2022-05-01" @default.
• W4213135975 modified "2023-10-11" @default.
• W4213135975 title "Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions" @default.
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• W4213135975 doi "https://doi.org/10.1016/j.lssr.2022.02.001" @default.
• W4213135975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35491026" @default.
• W4213135975 hasPublicationYear "2022" @default.
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