Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213144871> ?p ?o ?g. }
- W4213144871 endingPage "119020" @default.
- W4213144871 startingPage "119020" @default.
- W4213144871 abstract "Specific brain structures (gray matter regions and white matter tracts) play a dominant role in determining cognitive decline and explain the heterogeneity in cognitive aging. Identification of these structures is crucial for screening of older adults at risk of cognitive decline. Using deep learning models augmented with a model-interpretation technique on data from 1432 Mayo Clinic Study of Aging participants, we identified a subset of brain structures that were most predictive of individualized cognitive trajectories and indicative of cognitively resilient vs. vulnerable individuals. Specifically, these structures explained why some participants were resilient to the deleterious effects of elevated brain amyloid and poor vascular health. Of these, medial temporal lobe and fornix, reflective of age and pathology-related degeneration, and corpus callosum, reflective of inter-hemispheric disconnection, accounted for 60% of the heterogeneity explained by the most predictive structures. Our results are valuable for identifying cognitively vulnerable individuals and for developing interventions for cognitive decline." @default.
- W4213144871 created "2022-02-24" @default.
- W4213144871 creator A5005099850 @default.
- W4213144871 creator A5005572080 @default.
- W4213144871 creator A5008693997 @default.
- W4213144871 creator A5009154205 @default.
- W4213144871 creator A5026250910 @default.
- W4213144871 creator A5032297807 @default.
- W4213144871 creator A5035234218 @default.
- W4213144871 creator A5043921358 @default.
- W4213144871 creator A5045246745 @default.
- W4213144871 creator A5059027860 @default.
- W4213144871 creator A5059557996 @default.
- W4213144871 creator A5063489595 @default.
- W4213144871 creator A5067802693 @default.
- W4213144871 creator A5070511138 @default.
- W4213144871 creator A5080902463 @default.
- W4213144871 creator A5084310851 @default.
- W4213144871 creator A5088736025 @default.
- W4213144871 date "2022-05-01" @default.
- W4213144871 modified "2023-09-30" @default.
- W4213144871 title "Deep learning identifies brain structures that predict cognition and explain heterogeneity in cognitive aging" @default.
- W4213144871 cites W1967235520 @default.
- W4213144871 cites W1978879359 @default.
- W4213144871 cites W1981186475 @default.
- W4213144871 cites W1985747467 @default.
- W4213144871 cites W1987064062 @default.
- W4213144871 cites W198898569 @default.
- W4213144871 cites W1993571512 @default.
- W4213144871 cites W2020780341 @default.
- W4213144871 cites W2025457866 @default.
- W4213144871 cites W2028050242 @default.
- W4213144871 cites W2028908650 @default.
- W4213144871 cites W2058965862 @default.
- W4213144871 cites W2059481988 @default.
- W4213144871 cites W2067921473 @default.
- W4213144871 cites W2075437836 @default.
- W4213144871 cites W2076537684 @default.
- W4213144871 cites W2080211545 @default.
- W4213144871 cites W2081164888 @default.
- W4213144871 cites W2082533002 @default.
- W4213144871 cites W2084358449 @default.
- W4213144871 cites W2085037176 @default.
- W4213144871 cites W2085359313 @default.
- W4213144871 cites W2088540084 @default.
- W4213144871 cites W2092497652 @default.
- W4213144871 cites W2094016424 @default.
- W4213144871 cites W2098423038 @default.
- W4213144871 cites W2100651338 @default.
- W4213144871 cites W2104004753 @default.
- W4213144871 cites W2117971276 @default.
- W4213144871 cites W2124326624 @default.
- W4213144871 cites W2128149456 @default.
- W4213144871 cites W2136978757 @default.
- W4213144871 cites W2142180566 @default.
- W4213144871 cites W2143956675 @default.
- W4213144871 cites W2146336916 @default.
- W4213144871 cites W2147883225 @default.
- W4213144871 cites W2154158168 @default.
- W4213144871 cites W2159899308 @default.
- W4213144871 cites W2165013497 @default.
- W4213144871 cites W2167702959 @default.
- W4213144871 cites W2460653397 @default.
- W4213144871 cites W2530915672 @default.
- W4213144871 cites W2582496673 @default.
- W4213144871 cites W2747165584 @default.
- W4213144871 cites W2755130937 @default.
- W4213144871 cites W2761051660 @default.
- W4213144871 cites W2773828216 @default.
- W4213144871 cites W2797010042 @default.
- W4213144871 cites W2799964946 @default.
- W4213144871 cites W2806096513 @default.
- W4213144871 cites W2887096491 @default.
- W4213144871 cites W2891222261 @default.
- W4213144871 cites W2892013400 @default.
- W4213144871 cites W2901739937 @default.
- W4213144871 cites W2902911685 @default.
- W4213144871 cites W2915974650 @default.
- W4213144871 cites W2979863890 @default.
- W4213144871 cites W3046295428 @default.
- W4213144871 cites W3092252141 @default.
- W4213144871 cites W3094551933 @default.
- W4213144871 cites W3160467514 @default.
- W4213144871 cites W3215207525 @default.
- W4213144871 cites W4294557829 @default.
- W4213144871 doi "https://doi.org/10.1016/j.neuroimage.2022.119020" @default.
- W4213144871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35196565" @default.
- W4213144871 hasPublicationYear "2022" @default.
- W4213144871 type Work @default.
- W4213144871 citedByCount "2" @default.
- W4213144871 countsByYear W42131448712023 @default.
- W4213144871 crossrefType "journal-article" @default.
- W4213144871 hasAuthorship W4213144871A5005099850 @default.
- W4213144871 hasAuthorship W4213144871A5005572080 @default.
- W4213144871 hasAuthorship W4213144871A5008693997 @default.
- W4213144871 hasAuthorship W4213144871A5009154205 @default.
- W4213144871 hasAuthorship W4213144871A5026250910 @default.
- W4213144871 hasAuthorship W4213144871A5032297807 @default.