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- W4213144914 abstract "Aim: To investigate the function of broad-spectrum racemases in Aeromonas hydrophila (BsrA). Results: The A. hydrophila gene encoding BsrA (bsr) mutants (AHΔbsr) exhibited a significant decrease in growth, motility, extracellular protease production and biofilm formation compared with the wild-type. Furthermore, bsr gene knockout instigated cell wall damage compared with the wild-type strains. The survival rate and replication capability in the blood and organs of the AHΔbsr-infected mice were significantly decreased. The degree of tissue injury in the AHΔbsr-infected group was lower than that of the wild-type-infected group. Moreover, there was a significant decrease in the expression of 12 AHΔbsr virulence genes. Conclusion: The bsr gene is essential for the viability and virulence of A. hydrophila." @default.
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- W4213144914 date "2022-02-14" @default.
- W4213144914 modified "2023-10-16" @default.
- W4213144914 title "Significance of broad-spectrum racemases for the viability and pathogenicity of Aeromonas hydrophila" @default.
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- W4213144914 doi "https://doi.org/10.2217/fmb-2021-0112" @default.
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