FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213156610> ?p ?o ?g. }

• W4213156610 abstract "Peroxisomes are specialized cellular organelles involved in a variety of metabolic processes. In humans, mutations leading to complete loss of peroxisomes cause multiorgan failure (Zellweger's spectrum disorders, ZSD), including renal impairment. However, the (patho)physiological role of peroxisomes in the kidney remains unknown. We addressed the role of peroxisomes in renal function in mice with conditional ablation of peroxisomal biogenesis in the renal tubule (cKO mice). Functional analyses did not reveal any overt kidney phenotype in cKO mice. However, infant male cKO mice had lower body and kidney weights, and adult male cKO mice exhibited substantial reductions in kidney weight and kidney weight/body weight ratio. Stereological analysis showed an increase in mitochondria density in proximal tubule cells of cKO mice. Integrated transcriptome and metabolome analyses revealed profound reprogramming of a number of metabolic pathways, including metabolism of glutathione and biosynthesis/biotransformation of several major classes of lipids. Although this analysis suggested compensated oxidative stress, challenge with high-fat feeding did not induce significant renal impairments in cKO mice. We demonstrate that renal tubular peroxisomes are dispensable for normal renal function. Our data also suggest that renal impairments in patients with ZSD are of extrarenal origin." @default.
• W4213156610 created "2022-02-24" @default.
• W4213156610 creator A5001660720 @default.
• W4213156610 creator A5005291178 @default.
• W4213156610 creator A5019698168 @default.
• W4213156610 creator A5035150830 @default.
• W4213156610 creator A5040096802 @default.
• W4213156610 creator A5043051104 @default.
• W4213156610 creator A5043377919 @default.
• W4213156610 creator A5055783535 @default.
• W4213156610 creator A5056357963 @default.
• W4213156610 creator A5085786994 @default.
• W4213156610 date "2022-02-22" @default.
• W4213156610 modified "2023-10-10" @default.
• W4213156610 title "Renal tubular peroxisomes are dispensable for normal kidney function" @default.
• W4213156610 cites W1484929595 @default.
• W4213156610 cites W1771754722 @default.
• W4213156610 cites W1964697500 @default.
• W4213156610 cites W1966778844 @default.
• W4213156610 cites W1971364834 @default.
• W4213156610 cites W1979270243 @default.
• W4213156610 cites W2024467036 @default.
• W4213156610 cites W2033826732 @default.
• W4213156610 cites W2035618305 @default.
• W4213156610 cites W2039160682 @default.
• W4213156610 cites W2040365013 @default.
• W4213156610 cites W2050475853 @default.
• W4213156610 cites W2054557763 @default.
• W4213156610 cites W2094218895 @default.
• W4213156610 cites W2137526110 @default.
• W4213156610 cites W2146512944 @default.
• W4213156610 cites W2147691511 @default.
• W4213156610 cites W2167540700 @default.
• W4213156610 cites W2318537264 @default.
• W4213156610 cites W2791705347 @default.
• W4213156610 cites W2791808110 @default.
• W4213156610 cites W2914269374 @default.
• W4213156610 cites W3159995035 @default.
• W4213156610 doi "https://doi.org/10.1172/jci.insight.155836" @default.
• W4213156610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35191396" @default.
• W4213156610 hasPublicationYear "2022" @default.
• W4213156610 type Work @default.
• W4213156610 citedByCount "3" @default.
• W4213156610 countsByYear W42131566102022 @default.
• W4213156610 countsByYear W42131566102023 @default.
• W4213156610 crossrefType "journal-article" @default.
• W4213156610 hasAuthorship W4213156610A5001660720 @default.
• W4213156610 hasAuthorship W4213156610A5005291178 @default.
• W4213156610 hasAuthorship W4213156610A5019698168 @default.
• W4213156610 hasAuthorship W4213156610A5035150830 @default.
• W4213156610 hasAuthorship W4213156610A5040096802 @default.
• W4213156610 hasAuthorship W4213156610A5043051104 @default.
• W4213156610 hasAuthorship W4213156610A5043377919 @default.
• W4213156610 hasAuthorship W4213156610A5055783535 @default.
• W4213156610 hasAuthorship W4213156610A5056357963 @default.
• W4213156610 hasAuthorship W4213156610A5085786994 @default.
• W4213156610 hasBestOaLocation W42131566101 @default.
• W4213156610 hasConcept C126322002 @default.
• W4213156610 hasConcept C127078168 @default.
• W4213156610 hasConcept C134018914 @default.
• W4213156610 hasConcept C159641895 @default.
• W4213156610 hasConcept C170493617 @default.
• W4213156610 hasConcept C2777229759 @default.
• W4213156610 hasConcept C2780091579 @default.
• W4213156610 hasConcept C28859421 @default.
• W4213156610 hasConcept C55493867 @default.
• W4213156610 hasConcept C71924100 @default.
• W4213156610 hasConcept C86803240 @default.
• W4213156610 hasConcept C95444343 @default.
• W4213156610 hasConceptScore W4213156610C126322002 @default.
• W4213156610 hasConceptScore W4213156610C127078168 @default.
• W4213156610 hasConceptScore W4213156610C134018914 @default.
• W4213156610 hasConceptScore W4213156610C159641895 @default.
• W4213156610 hasConceptScore W4213156610C170493617 @default.
• W4213156610 hasConceptScore W4213156610C2777229759 @default.
• W4213156610 hasConceptScore W4213156610C2780091579 @default.
• W4213156610 hasConceptScore W4213156610C28859421 @default.
• W4213156610 hasConceptScore W4213156610C55493867 @default.
• W4213156610 hasConceptScore W4213156610C71924100 @default.
• W4213156610 hasConceptScore W4213156610C86803240 @default.
• W4213156610 hasConceptScore W4213156610C95444343 @default.
• W4213156610 hasFunder F4320320924 @default.
• W4213156610 hasIssue "4" @default.
• W4213156610 hasLocation W42131566101 @default.
• W4213156610 hasLocation W42131566102 @default.
• W4213156610 hasLocation W42131566103 @default.
• W4213156610 hasLocation W42131566104 @default.
• W4213156610 hasOpenAccess W4213156610 @default.
• W4213156610 hasPrimaryLocation W42131566101 @default.
• W4213156610 hasRelatedWork W2020959757 @default.
• W4213156610 hasRelatedWork W2042033030 @default.
• W4213156610 hasRelatedWork W2044943066 @default.
• W4213156610 hasRelatedWork W2050472553 @default.
• W4213156610 hasRelatedWork W2070511355 @default.
• W4213156610 hasRelatedWork W2113143771 @default.
• W4213156610 hasRelatedWork W2127085070 @default.
• W4213156610 hasRelatedWork W2400445066 @default.
• W4213156610 hasRelatedWork W2888827192 @default.
• W4213156610 hasRelatedWork W2951565157 @default.
• W4213156610 hasVolume "7" @default.

• next